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H9ZSV8 (H9ZSV8_THETH) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length327 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity. HAMAP-Rule MF_01517

Catalytic activity

(S)-malate + NAD+ = oxaloacetate + NADH. RuleBase RU000422 HAMAP-Rule MF_01517

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01517 SAAS SAAS010945

Sequence similarities

Belongs to the LDH/MDH superfamily. MDH type 2 family. RuleBase RU000421 HAMAP-Rule MF_01517

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding11 – 177NAD By similarity HAMAP-Rule MF_01517
Nucleotide binding129 – 1313NAD By similarity HAMAP-Rule MF_01517

Sites

Active site1871Proton acceptor By similarity HAMAP-Rule MF_01517
Binding site921Substrate By similarity HAMAP-Rule MF_01517
Binding site981Substrate By similarity HAMAP-Rule MF_01517
Binding site1051NAD By similarity HAMAP-Rule MF_01517
Binding site1121NAD By similarity HAMAP-Rule MF_01517
Binding site1311Substrate By similarity HAMAP-Rule MF_01517
Binding site1621Substrate By similarity HAMAP-Rule MF_01517

Sequences

Sequence LengthMass (Da)Tools
H9ZSV8 [UniParc].

Last modified June 13, 2012. Version 1.
Checksum: 51621169BFD481B6

FASTA32735,469
        10         20         30         40         50         60 
MKAPVRVAVT GAAGQIGYSL LFRIAAGEML GKDQPVILQL LEIPQAMKAL EGVVMELEDC 

        70         80         90        100        110        120 
AFPLLAGLEA TDDPKVAFKD ADYALLVGAA PRKAGMERRD LLEMNGKIFT EQGRALAEVA 

       130        140        150        160        170        180 
KKDVKVLVVG NPANTNALIA YKNAPGLNPR NFTAMTRLDH NRAKAQLAKK TGVPVDRIRR 

       190        200        210        220        230        240 
MTVWGNHSST MFPDLFHAEV DGRPALELVD MEWYEKVFIP TVAQRGAAII QARGASSAAS 

       250        260        270        280        290        300 
AANAAIEHIR DWALGTPEGD WVSMAVPSQG EYGIPEGIVY SFPVTAKDGA YQVVEGLEIN 

       310        320 
EFARKRMELT AQELLDEMEQ VKALGLI 

« Hide

References

[1]US DOE Joint Genome Institute
Lucas S., Han J., Lapidus A., Cheng J.-F., Goodwin L., Pitluck S., Peters L., Mikhailova N., Teshima H., Detter J.C., Han C., Tapia R., Land M., Hauser L., Kyrpides N., Ivanova N., Pagani I., Lam J. expand/collapse author list , McDonald A., Dodsworth J., Hedlund B., Woyke T.
Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: JL-18 EMBL AFH39418.1.
[2]"Whole Genome Sequencing of Thermus oshimai JL-2 and Thermus thermophilus JL-18, Incomplete Denitrifiers from the United States Great Basin."
Murugapiran S.K., Huntemann M., Wei C.L., Han J., Detter J.C., Han C.S., Erkkila T.H., Teshima H., Chen A., Kyrpides N., Mavrommatis K., Markowitz V., Szeto E., Ivanova N., Pagani I., Lam J., McDonald A.I., Dodsworth J.A. expand/collapse author list , Pati A., Goodwin L., Peters L., Pitluck S., Woyke T., Hedlund B.P.
Genome Announc. 1:E00106-E00112(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: JL-18 EMBL AFH39418.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003252 Genomic DNA. Translation: AFH39418.1.
RefSeqYP_006059204.1. NC_017587.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFH39418; AFH39418; TtJL18_1540.
GeneID12654214.
KEGGttl:TtJL18_1540.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK00024.

Enzyme and pathway databases

BioCycTTHE798128:GLMF-1539-MONOMER.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPMF_01517. Malate_dehydrog_2.
InterProIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010945. Malate_DH_type2.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERPTHR23382. PTHR23382. 1 hit.
PfamPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMSSF56327. SSF56327. 1 hit.
TIGRFAMsTIGR01759. MalateDH-SF1. 1 hit.
PROSITEPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH9ZSV8_THETH
AccessionPrimary (citable) accession number: H9ZSV8
Entry history
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: June 11, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)