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Protein

NADPH:adrenodoxin oxidoreductase, mitochondrial

Gene

FDXR

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

2 reduced adrenodoxin + NADP+ = 2 oxidized adrenodoxin + NADPH.UniRule annotation

Cofactori

FADUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei49FAD; via amide nitrogenUniRule annotation1
Binding sitei69FADUniRule annotation1
Binding sitei77FAD; via amide nitrogenUniRule annotation1
Binding sitei113FAD; via amide nitrogen and carbonyl oxygenUniRule annotation1
Binding sitei240NADPUniRule annotation1
Binding sitei398FAD; via amide nitrogenUniRule annotation1
Binding sitei405NADP; via amide nitrogenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi184 – 187NADPUniRule annotation4
Nucleotide bindingi228 – 229NADPUniRule annotation2
Nucleotide bindingi405 – 407FADUniRule annotation3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandFADUniRule annotation, Flavoprotein, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
NADPH:adrenodoxin oxidoreductase, mitochondrialUniRule annotation (EC:1.18.1.6UniRule annotation)
Gene namesi
Name:FDXRImported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MitochondrionUniRule annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini40 – 195FAD/NAD-binding_domInterPro annotationAdd BLAST156

Sequence similaritiesi

Belongs to the ferredoxin--NADP reductase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1800. Eukaryota.
COG0493. LUCA.

Family and domain databases

Gene3Di3.50.50.60. 2 hits.
InterProiView protein in InterPro
IPR036188. FAD/NAD-bd_sf.
IPR023753. FAD/NAD-binding_dom.
IPR021163. Ferredox_Rdtase_adrenod.
PfamiView protein in Pfam
PF07992. Pyr_redox_2. 1 hit.
PIRSFiPIRSF000362. FNR. 1 hit.
SUPFAMiSSF51905. SSF51905. 1 hit.

Sequencei

Sequence statusi: Complete.

H9YWH2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRCWRWWG WSAWPRTRPP PAGSTPSFRH HLSTQEKTPQ ICVVGSGPAG
60 70 80 90 100
FYTAQHLLKH PQAHVDIYEK QPVPFGLVRF GVAPDHPEVK NVINTFTQTA
110 120 130 140 150
HSGRCAFWGN VEVGRDVTVP ELREAYHAVV LSYGAEDHRA LEIPGEELPG
160 170 180 190 200
VCSARAFVGW YNGLPENREL EPDLSCDTAV ILGQGNVALD VARILLTPPE
210 220 230 240 250
HLERTDITKA ALGVLRQSRV KTVWLVGRRG PLQVAFTIKE LREMIQLPGA
260 270 280 290 300
RPILDPADFL GLQDKIKEVP RPRKRLTELL LRTATEKPGP EEAARWASAS
310 320 330 340 350
RAWGLRFFRS PQQVLPSPDG RRAAGVRLAV TRLEGVGEAT RAVPTGDMED
360 370 380 390 400
LPCGLVLSSV GYKSRPVDPS VPFDSKLGVI PNVEGRVMDV PGLYCSGWVK
410 420 430 440 450
RGPTGVIATT MTDSFLTGQM LLQDLKAGLL PSGPRPGYAA IQALLSSRGV
460 470 480 490
RPVSFSDWEK LDAEEVARGQ GTGKPREKLV DPQEMLRLLG H
Length:491
Mass (Da):53,884
Last modified:June 13, 2012 - v1
Checksum:i350AB89995DCEA4A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JU471234 mRNA. Translation: AFH28038.1.
JV046460 mRNA. Translation: AFI36531.1.
JV636030 mRNA. Translation: AFJ71370.1.
RefSeqiXP_014975770.1. XM_015120284.1.
UniGeneiMmu.21094.

Genome annotation databases

GeneIDi699336.

Similar proteinsi

Entry informationi

Entry nameiH9YWH2_MACMU
AccessioniPrimary (citable) accession number: H9YWH2
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: March 28, 2018
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)