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H9UJT0 (H9UJT0_SPIAZ) Unreviewed, UniProtKB/TrEMBL

Last modified March 19, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Spiaf_1716 EMBL AFG37773.1
OrganismSpirochaeta africana (strain ATCC 700263 / DSM 8902 / Z-7692) [Complete proteome] [HAMAP] EMBL AFG37773.1
Taxonomic identifier889378 [NCBI]
Taxonomic lineageBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta

Protein attributes

Sequence length358 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain135 – 342208ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding168 – 22356ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2951Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3091Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3091Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3111Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
H9UJT0 [UniParc].

Last modified June 13, 2012. Version 1.
Checksum: 2F2E5B1D24C0185C

FASTA35839,614
        10         20         30         40         50         60 
MRTAIIYGGR SGEHDVSCVS AASVLRWIDR SRFEPVPIGI DRSGSWYLQS IPDDIHSDGH 

        70         80         90        100        110        120 
PLAVAVPGQG AIGFQPGSGL TCNGRSLDID IVFPVLHGTF GEDGTIQGLL DMLDLAYVGS 

       130        140        150        160        170        180 
GVLGSSLSMD KVLTKQIWEQ HGLPVVPYIA LQHHHYLGDP ARQLDRIIHQ LELPVFIKPA 

       190        200        210        220        230        240 
RGGSSVGVHK AHDRQELENC LADAFRYDTK LILEKSVTAT EIECSVLGNR EPEVFPPASI 

       250        260        270        280        290        300 
TPTHEYYDYE AKYQDPDGAH FSLPADIPAH VADRISQLAL KAFVAVEARG LSRVDFFYSE 

       310        320        330        340        350 
QTGELYLNEI NTMPGFTAIS LFPRMCEHGG LPYQQLITRL IELAREEHTL RDSLRYSR 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003282 Genomic DNA. Translation: AFG37773.1.
RefSeqYP_005475480.1. NC_017098.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFG37773; AFG37773; Spiaf_1716.
GeneID12061895.
KEGGsfc:Spiaf_1716.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAMDKIAMK.

Enzyme and pathway databases

BioCycSAFR889378:GLKD-1716-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH9UJT0_SPIAZ
AccessionPrimary (citable) accession number: H9UJT0
Entry history
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: March 19, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)