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H9UJT0

- H9UJT0_SPIAZ

UniProt

H9UJT0 - H9UJT0_SPIAZ

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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Spirochaeta africana (strain ATCC 700263 / DSM 8902 / Z-7692)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Binds 2 magnesium or manganese ions per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi295 – 2951Magnesium or manganese 1UniRule annotation
Metal bindingi309 – 3091Magnesium or manganese 1UniRule annotation
Metal bindingi309 – 3091Magnesium or manganese 2UniRule annotation
Metal bindingi311 – 3111Magnesium or manganese 2UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi168 – 22356ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotation

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciSAFR889378:GLKD-1716-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Spiaf_1716Imported
OrganismiSpirochaeta africana (strain ATCC 700263 / DSM 8902 / Z-7692)Imported
Taxonomic identifieri889378 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta
ProteomesiUP000007383: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini135 – 342208ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

KOiK01921.
OMAiRSAYGIY.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H9UJT0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTAIIYGGR SGEHDVSCVS AASVLRWIDR SRFEPVPIGI DRSGSWYLQS
60 70 80 90 100
IPDDIHSDGH PLAVAVPGQG AIGFQPGSGL TCNGRSLDID IVFPVLHGTF
110 120 130 140 150
GEDGTIQGLL DMLDLAYVGS GVLGSSLSMD KVLTKQIWEQ HGLPVVPYIA
160 170 180 190 200
LQHHHYLGDP ARQLDRIIHQ LELPVFIKPA RGGSSVGVHK AHDRQELENC
210 220 230 240 250
LADAFRYDTK LILEKSVTAT EIECSVLGNR EPEVFPPASI TPTHEYYDYE
260 270 280 290 300
AKYQDPDGAH FSLPADIPAH VADRISQLAL KAFVAVEARG LSRVDFFYSE
310 320 330 340 350
QTGELYLNEI NTMPGFTAIS LFPRMCEHGG LPYQQLITRL IELAREEHTL

RDSLRYSR
Length:358
Mass (Da):39,614
Last modified:June 13, 2012 - v1
Checksum:i2F2E5B1D24C0185C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003282 Genomic DNA. Translation: AFG37773.1.
RefSeqiWP_014455756.1. NC_017098.1.
YP_005475480.1. NC_017098.1.

Genome annotation databases

EnsemblBacteriaiAFG37773; AFG37773; Spiaf_1716.
GeneIDi12061895.
KEGGisfc:Spiaf_1716.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003282 Genomic DNA. Translation: AFG37773.1 .
RefSeqi WP_014455756.1. NC_017098.1.
YP_005475480.1. NC_017098.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFG37773 ; AFG37773 ; Spiaf_1716 .
GeneIDi 12061895.
KEGGi sfc:Spiaf_1716.

Phylogenomic databases

KOi K01921.
OMAi RSAYGIY.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci SAFR889378:GLKD-1716-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ATCC 700263 / DSM 8902 / Z-7692Imported.

Entry informationi

Entry nameiH9UJT0_SPIAZ
AccessioniPrimary (citable) accession number: H9UJT0
Entry historyi
Integrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: October 29, 2014
This is version 18 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3