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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Spirochaeta africana (strain ATCC 700263 / DSM 8902 / Z-7692)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 2 magnesium or manganese ions per subunit.UniRule annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi295Magnesium or manganese 1UniRule annotation1
Metal bindingi309Magnesium or manganese 1UniRule annotation1
Metal bindingi309Magnesium or manganese 2UniRule annotation1
Metal bindingi311Magnesium or manganese 2UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseUniRule annotationSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotationSAAS annotation (EC:6.3.2.4UniRule annotationSAAS annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Spiaf_1716Imported
OrganismiSpirochaeta africana (strain ATCC 700263 / DSM 8902 / Z-7692)Imported
Taxonomic identifieri889378 [NCBI]
Taxonomic lineageiBacteriaSpirochaetesSpirochaetalesSpirochaetaceaeSpirochaeta
Proteomesi
  • UP000007383 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 342ATP-graspInterPro annotationAdd BLAST208

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01921.
OMAiYETKYTE.
OrthoDBiPOG091H06GK.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
PIRSFiPIRSF039102. Ddl/VanB. 1 hit.
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

H9UJT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTAIIYGGR SGEHDVSCVS AASVLRWIDR SRFEPVPIGI DRSGSWYLQS
60 70 80 90 100
IPDDIHSDGH PLAVAVPGQG AIGFQPGSGL TCNGRSLDID IVFPVLHGTF
110 120 130 140 150
GEDGTIQGLL DMLDLAYVGS GVLGSSLSMD KVLTKQIWEQ HGLPVVPYIA
160 170 180 190 200
LQHHHYLGDP ARQLDRIIHQ LELPVFIKPA RGGSSVGVHK AHDRQELENC
210 220 230 240 250
LADAFRYDTK LILEKSVTAT EIECSVLGNR EPEVFPPASI TPTHEYYDYE
260 270 280 290 300
AKYQDPDGAH FSLPADIPAH VADRISQLAL KAFVAVEARG LSRVDFFYSE
310 320 330 340 350
QTGELYLNEI NTMPGFTAIS LFPRMCEHGG LPYQQLITRL IELAREEHTL

RDSLRYSR
Length:358
Mass (Da):39,614
Last modified:June 13, 2012 - v1
Checksum:i2F2E5B1D24C0185C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003282 Genomic DNA. Translation: AFG37773.1.
RefSeqiWP_014455756.1. NC_017098.1.

Genome annotation databases

EnsemblBacteriaiAFG37773; AFG37773; Spiaf_1716.
KEGGisfc:Spiaf_1716.
PATRICifig|889378.3.peg.1702.

Similar proteinsi

Entry informationi

Entry nameiH9UJT0_SPIAZ
AccessioniPrimary (citable) accession number: H9UJT0
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: September 27, 2017
This is version 41 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported