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Protein

D-alanine--D-alanine ligase

Gene

Ferpe_0742

Organism
Fervidobacterium pennivorans (strain DSM 9078 / Ven5)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation.SAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.SAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Mg2+SAAS annotation
  • Mn2+SAAS annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.SAAS annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigaseSAAS annotationImported
Biological processCell shape, Cell wall biogenesis/degradationSAAS annotation, Peptidoglycan synthesisSAAS annotation
LigandATP-bindingPROSITE-ProRule annotationSAAS annotation, MagnesiumSAAS annotation, ManganeseSAAS annotation, Metal-bindingSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciFPEN771875:GLDA-716-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseSAAS annotation (EC:6.3.2.4SAAS annotation)
Gene namesi
Ordered Locus Names:Ferpe_0742Imported
OrganismiFervidobacterium pennivorans (strain DSM 9078 / Ven5)Imported
Taxonomic identifieri771875 [NCBI]
Taxonomic lineageiBacteriaThermotogaeThermotogalesFervidobacteriaceaeFervidobacterium
Proteomesi
  • UP000007384 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 297ATP-graspInterPro annotationAdd BLAST205

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.SAAS annotation

Phylogenomic databases

KOiK01921.
OMAiDINPNCD.
OrthoDBiPOG091H1LUD.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
InterProiView protein in InterPro
IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR011095. Dala_Dala_lig_C.
PfamiView protein in Pfam
PF07478. Dala_Dala_lig_C. 1 hit.
PROSITEiView protein in PROSITE
PS50975. ATP_GRASP. 1 hit.

Sequencei

Sequence statusi: Complete.

H9UBG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIAIAYDKS NLDNERWKMV QSVSEALSKK YDAEPVAFED NFCEKVKKYD
60 70 80 90 100
AVFNLSTAYK QMHVPAILEV LKIPFTGSSA AAHALCIDKL KTKIILKHFG
110 120 130 140 150
IPTPDFISVD LDEEVPEIDF YPAIVKPVKE GSAKGIYADS VVHNHEELKE
160 170 180 190 200
KVLRVHKEFE QPALVEQFIE GDREYSIGIV GSKVLPILEI DFSSLPEGLE
210 220 230 240 250
RFYSHRVKHE YGEQTTYICP AQLTEELKAQ IEHYALKSFK VLGLRNYARM
260 270 280 290 300
DLRVKDGKIY FLEANSLPML TPNYSDIIKM AQAAGYTYDE FILTIFEDAL

RK
Length:302
Mass (Da):34,483
Last modified:June 13, 2012 - v1
Checksum:i8022BA015BA91AEC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003260 Genomic DNA. Translation: AFG34862.1.
RefSeqiWP_014451306.1. NC_017095.1.

Genome annotation databases

EnsemblBacteriaiAFG34862; AFG34862; Ferpe_0742.
KEGGifpe:Ferpe_0742.
PATRICifig|771875.3.peg.761.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiH9UBG9_FERPD
AccessioniPrimary (citable) accession number: H9UBG9
Entry historyiIntegrated into UniProtKB/TrEMBL: June 13, 2012
Last sequence update: June 13, 2012
Last modified: June 7, 2017
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported