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Protein

Alpha-conotoxin Li1.12

Gene
N/A
Organism
Conus lividus (Livid cone)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits alpha-3-beta-4, alpha-6/alpha-3-beta-4, and alpha-2-beta-4 nAChRs.By similarity

Miscellaneous

This toxin does not show inhibition at neuronal alpha-4-beta-4, alpha-4-beta-2, alpha-6/alpha-3-beta-2-beta-3, alpha-3-beta-2, alpha-2-beta-2, alpha-9-alpha-10, alpha-7 nAChRs and muscle alpha-1-beta-1-delta-epsilon nAChR.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-conotoxin Li1.12
Alternative name(s):
Livi_231 Publication
OrganismiConus lividus (Livid cone)
Taxonomic identifieri89426 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_0000439432‹1 – 15By similarityAdd BLAST›15
PeptideiPRO_000043943316 – 30Alpha-conotoxin Li1.12By similarityAdd BLAST15

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi17 ↔ 23By similarity
Disulfide bondi18 ↔ 30By similarity
Modified residuei30Cysteine amideBy similarity1

Keywords - PTMi

Amidation, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom duct.Curated

Structurei

3D structure databases

SMRiH9N3R7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is I (CC-C-C). Alpha4/6 pattern.By similarity

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Family and domain databases

InterProiView protein in InterPro
IPR009958. Conotoxin_a-typ.
PfamiView protein in Pfam
PF07365. Toxin_8. 1 hit.

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

H9N3R7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30 
AGNAKMSALM ALTIRGCCSH PVCSAMSPIC G
Length:31
Mass (Da):3,082
Last modified:June 13, 2012 - v1
Checksum:i79DAD3E923F46113
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JF723419 Genomic DNA. Translation: AFD18484.1.

Similar proteinsi

Entry informationi

Entry nameiCA1C_CONLI
AccessioniPrimary (citable) accession number: H9N3R7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 12, 2017
Last sequence update: June 13, 2012
Last modified: November 22, 2017
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families