ID LP3_BOMMO Reviewed; 256 AA. AC Q00802; H9J4F6; DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot. DT 10-FEB-2021, sequence version 2. DT 24-JAN-2024, entry version 67. DE RecName: Full=Low molecular mass lipoprotein 3 {ECO:0000303|Ref.5}; DE Short=Bmlp3 {ECO:0000303|Ref.5}; DE AltName: Full=30 KDa protein 1 {ECO:0000303|PubMed:26078299}; DE Short=Bm30K-1 {ECO:0000303|PubMed:26078299}; DE AltName: Full=30 KDa protein 19G1 {ECO:0000303|PubMed:1883839}; DE Flags: Precursor; GN Name=LP3 {ECO:0000303|Ref.5}; OS Bombyx mori (Silk moth). OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; OC Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea; OC Bombycidae; Bombycinae; Bombyx. OX NCBI_TaxID=7091; RN [1] {ECO:0000312|EMBL:AFC87799.1} RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, RP DEVELOPMENTAL STAGE, AND IDENTIFICATION BY MASS SPECTROMETRY. RX PubMed=26078299; DOI=10.1093/jisesa/iev057; RA Shi X.F., Li Y.N., Yi Y.Z., Xiao X.G., Zhang Z.F.; RT "Identification and Characterization of 30 K Protein Genes Found in Bombyx RT mori (Lepidoptera: Bombycidae) Transcriptome."; RL J. Insect Sci. 15:71-71(2015). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RC STRAIN=Tokai X Asahi; TISSUE=Fat body; RX PubMed=1883839; DOI=10.1016/0167-4781(91)90048-q; RA Mori S., Izumi S., Tomino S.; RT "Complete nucleotide sequences of major plasma protein genes of Bombyx RT mori."; RL Biochim. Biophys. Acta 1090:129-132(1991). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=p50T; RX PubMed=15591204; DOI=10.1126/science.1102210; RA Xia Q., Zhou Z., Lu C., Cheng D., Dai F., Li B., Zhao P., Zha X., Cheng T., RA Chai C., Pan G., Xu J., Liu C., Lin Y., Qian J., Hou Y., Wu Z., Li G., RA Pan M., Li C., Shen Y., Lan X., Yuan L., Li T., Xu H., Yang G., Wan Y., RA Zhu Y., Yu M., Shen W., Wu D., Xiang Z., Yu J., Wang J., Li R., Shi J., RA Li H., Li G., Su J., Wang X., Li G., Zhang Z., Wu Q., Li J., Zhang Q., RA Wei N., Xu J., Sun H., Dong L., Liu D., Zhao S., Zhao X., Meng Q., Lan F., RA Huang X., Li Y., Fang L., Li C., Li D., Sun Y., Zhang Z., Yang Z., RA Huang Y., Xi Y., Qi Q., He D., Huang H., Zhang X., Wang Z., Li W., Cao Y., RA Yu Y., Yu H., Li J., Ye J., Chen H., Zhou Y., Liu B., Wang J., Ye J., RA Ji H., Li S., Ni P., Zhang J., Zhang Y., Zheng H., Mao B., Wang W., Ye C., RA Li S., Wang J., Wong G.K.-S., Yang H.; RT "A draft sequence for the genome of the domesticated silkworm (Bombyx RT mori)."; RL Science 306:1937-1940(2004). RN [4] {ECO:0007744|PDB:4IY8, ECO:0007744|PDB:4IY9} RP PROTEIN SEQUENCE OF 18-27, X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF RP 18-256, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY. RX PubMed=23613829; DOI=10.1371/journal.pone.0061303; RA Pietrzyk A.J., Bujacz A., Mueller-Dieckmann J., Lochynska M., Jaskolski M., RA Bujacz G.; RT "Two crystal structures of Bombyx mori lipoprotein 3 - structural RT characterization of a new 30-kDa lipoprotein family member."; RL PLoS ONE 8:e61303-e61303(2013). RN [5] {ECO:0000305} RP NOMENCLATURE, AND DEVELOPMENTAL STAGE. RX DOI=10.1111/j.1744-7917.2007.00121.x; RA Sun Q., Zhao P., Lin Y., Hou Y., Xia Q.-Y., Xiang Z.-H.; RT "Analysis of the structure and expression of the 30K protein genes in RT silkworm, Bombyx mori."; RL Insect Sci. 14:5-14(2007). CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23613829, CC ECO:0000269|PubMed:26078299}. CC -!- TISSUE SPECIFICITY: Detected in larval hemolymph (at protein level). CC {ECO:0000269|PubMed:23613829, ECO:0000269|PubMed:26078299}. CC -!- DEVELOPMENTAL STAGE: Expressed in fat body from the fifth larval instar CC through to the pupal stage (PubMed:26078299, Ref.5). Highest expression CC levels are found at the wandering stage which marks the transition from CC larva to pupa (Ref.5). Expression then declines during later pupal CC stages (Ref.5). {ECO:0000269|PubMed:26078299, ECO:0000269|Ref.5}. CC -!- MISCELLANEOUS: This lipoprotein belongs to the group of structurally CC related '30 kDa proteins' that comprise major protein components of the CC fifth (and last) instar larvae and of pupae. {ECO:0000305}. CC -!- SIMILARITY: Belongs to the 30 kDa lipoprotein family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; JN977519; AFC87799.1; -; mRNA. DR EMBL; X54736; CAA38533.1; -; Genomic_DNA. DR EMBL; BABH01021937; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR PIR; S17662; S17662. DR RefSeq; XP_012550498.1; XM_012695044.1. DR RefSeq; XP_012550504.1; XM_012695050.1. DR PDB; 4IY8; X-ray; 2.36 A; A/B/C/D=18-256. DR PDB; 4IY9; X-ray; 2.10 A; A/B=18-256. DR PDBsum; 4IY8; -. DR PDBsum; 4IY9; -. DR AlphaFoldDB; Q00802; -. DR SMR; Q00802; -. DR PaxDb; 7091-BGIBMGA004396-TA; -. DR EnsemblMetazoa; XM_012695044.3; XP_012550498.1; GeneID_693044. DR EnsemblMetazoa; XM_012695050.3; XP_012550504.1; GeneID_693044. DR GeneID; 693044; -. DR CTD; 693044; -. DR HOGENOM; CLU_053201_2_0_1; -. DR InParanoid; Q00802; -. DR OrthoDB; 3246586at2759; -. DR Proteomes; UP000005204; Unassembled WGS sequence. DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. DR Gene3D; 2.80.10.50; -; 1. DR Gene3D; 1.10.10.2400; Lepidopteran low molecular weight (30 kD) lipoprotein, N-terminal domain; 1. DR InterPro; IPR004943; Lipoprotein_11. DR InterPro; IPR042046; Lipoprotein_11_N. DR Pfam; PF03260; Lipoprotein_11; 1. PE 1: Evidence at protein level; KW 3D-structure; Direct protein sequencing; Lipoprotein; Reference proteome; KW Secreted; Signal. FT SIGNAL 1..17 FT /evidence="ECO:0000269|PubMed:23613829" FT CHAIN 18..256 FT /note="Low molecular mass lipoprotein 3" FT /id="PRO_0000021572" FT CONFLICT 132 FT /note="A -> R (in Ref. 2; CAA38533)" FT /evidence="ECO:0000305" FT HELIX 19..21 FT /evidence="ECO:0007829|PDB:4IY8" FT HELIX 24..36 FT /evidence="ECO:0007829|PDB:4IY9" FT HELIX 40..52 FT /evidence="ECO:0007829|PDB:4IY9" FT HELIX 56..68 FT /evidence="ECO:0007829|PDB:4IY9" FT HELIX 73..83 FT /evidence="ECO:0007829|PDB:4IY9" FT HELIX 87..93 FT /evidence="ECO:0007829|PDB:4IY9" FT HELIX 96..102 FT /evidence="ECO:0007829|PDB:4IY9" FT STRAND 107..111 FT /evidence="ECO:0007829|PDB:4IY9" FT TURN 112..115 FT /evidence="ECO:0007829|PDB:4IY9" FT STRAND 116..120 FT /evidence="ECO:0007829|PDB:4IY9" FT STRAND 125..128 FT /evidence="ECO:0007829|PDB:4IY9" FT STRAND 130..137 FT /evidence="ECO:0007829|PDB:4IY9" FT STRAND 139..141 FT /evidence="ECO:0007829|PDB:4IY9" FT HELIX 142..144 FT /evidence="ECO:0007829|PDB:4IY9" FT STRAND 146..153 FT /evidence="ECO:0007829|PDB:4IY9" FT STRAND 156..163 FT /evidence="ECO:0007829|PDB:4IY9" FT TURN 164..167 FT /evidence="ECO:0007829|PDB:4IY9" FT STRAND 168..176 FT /evidence="ECO:0007829|PDB:4IY9" FT STRAND 182..188 FT /evidence="ECO:0007829|PDB:4IY9" FT HELIX 193..195 FT /evidence="ECO:0007829|PDB:4IY9" FT STRAND 197..204 FT /evidence="ECO:0007829|PDB:4IY9" FT STRAND 207..214 FT /evidence="ECO:0007829|PDB:4IY9" FT TURN 215..217 FT /evidence="ECO:0007829|PDB:4IY9" FT STRAND 220..223 FT /evidence="ECO:0007829|PDB:4IY9" FT STRAND 233..238 FT /evidence="ECO:0007829|PDB:4IY9" FT HELIX 246..249 FT /evidence="ECO:0007829|PDB:4IY9" FT STRAND 251..254 FT /evidence="ECO:0007829|PDB:4IY9" SQ SEQUENCE 256 AA; 29414 MW; 413A8F8D30C94B0A CRC64; MKPAIVILCL FVASLYAADS DVPNDILEEQ LYNSVVVADY DSAVEKSKHL YEEKKSEVIT NVVNKLIRNN KMNCMEYAYQ LWLQGSKDIV RDCFPVEFRL IFAENAIKLM YKRDGLALTL SNDVQGDDGR PAYGDGKDKT SPRVSWKLIA LWENNKVYFK ILNTERNQYL VLGVGTNWNG DHMAFGVNSV DSFRAQWYLQ PAKYDNDVLF YIYNREYSKA LTLSRTVEPS GHRMAWGYNG RVIGSPEHYA WGIKAF //