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Protein

Hexokinase

Gene

HKDC1

Organism
Monodelphis domestica (Gray short-tailed opossum)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + D-hexose = ADP + D-hexose 6-phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
HexokinaseUniRule annotation (EC:2.7.1.1UniRule annotation)
Gene namesi
Name:HKDC1Imported
OrganismiMonodelphis domestica (Gray short-tailed opossum)Imported
Taxonomic identifieri13616 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaMetatheriaDidelphimorphiaDidelphidaeMonodelphis
ProteomesiUP000002280 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi13616.ENSMODP00000013383.

Family & Domainsi

Sequence similaritiesi

Belongs to the hexokinase family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000017159.
InParanoidiH9H6E5.
KOiK00844.
OMAiMCYMEEM.
OrthoDBiEOG7S21X5.
TreeFamiTF314238.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H9H6E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAVHLLAFY FTKLKEDQIK KVDRFLYHLR LSDDTLLDIM TRFRAEMEKG
60 70 80 90 100
LGKDTNPTAC VKMLPTFVRA IPDGSEKGEF LALDLGGSKF RVLTVRVSEE
110 120 130 140 150
GKPNVHMESQ IYPTPKEIIH GSGSELFDYV ADCAADFVKT RDLAHKKLPL
160 170 180 190 200
GLTFSFPCQQ SKLEEGILLS WTKKFKVRGV QDTDVVSSLT RALRRHQDVD
210 220 230 240 250
VDVLALVNDT VATMMTCAYD DPRCEVGVII GTGTNACYME DMSNIDLVEG
260 270 280 290 300
DEGRMAINTE WGAFGEDGAL EDIRTEFDRE LDLGSINPGK QLFEKMISGL
310 320 330 340 350
YIGELVRLIL LKMTKAGLLF QGEKSSALHT KGKIETRHVA LMEKYKEGLQ
360 370 380 390 400
NTREILRELG LEPSEEDCVA VQHVCTIVSF RSANLCAAAL AAILNRLREN
410 420 430 440 450
RRLTRLRTTV GMDGTLYKTH PQYPKRLHKV VRKLVPNCDV RFLLSESGSA
460 470 480 490 500
KGAAMVTAVA ARVQAQRKVI DEVLALFQLT REHLVSVKNK MRSEMEYGLK
510 520 530 540 550
KETQPLATVK MLPTYVCAMP DGTEKGKYLA LDLGGTNFRV LLVKIRSGRR
560 570 580 590 600
SVRMYNKIFA IPLEIMQGTG EELFDHIVQC IADFLDYMGI KGASKLPLGF
610 620 630 640 650
TFSFPCKQNC LDKGILVEWT KGFKATDCEG EDVVDMLREA IKRRNEFELD
660 670 680 690 700
VVAVLNDTVG TMMTCAYEDP ACEIGLIAGT GSNVCYMEEM RNIELVEGDE
710 720 730 740 750
GIMCINTEWG GFGDNGCLDE IRTQYDVEVD EGSLNPGKQR YEKMTSGMYL
760 770 780 790 800
GEIVRQILID LTKHGLLFRG QISERLRTRG IFETKFLSQI ESDRLALLQV
810 820 830 840 850
RRILQQLGLD STCEDSIVVK EVCGAVSRRA AQLCGAGLAA IVEKRREDRG
860 870 880 890 900
LERLAITVGV DGTLYKLHPH FSRILRETVH ALAPRCDVTF MLSEDGSGKG
910
AALITAVAKR LHLKKDH
Length:917
Mass (Da):102,519
Last modified:January 9, 2013 - v2
Checksum:i0CA256EEFC9D4FF9
GO

Sequence databases

RefSeqiXP_001364147.1. XM_001364110.2.

Genome annotation databases

EnsembliENSMODT00000013628; ENSMODP00000013383; ENSMODG00000010681.
GeneIDi100015984.
KEGGimdo:100015984.

Cross-referencesi

Sequence databases

RefSeqiXP_001364147.1. XM_001364110.2.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi13616.ENSMODP00000013383.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMODT00000013628; ENSMODP00000013383; ENSMODG00000010681.
GeneIDi100015984.
KEGGimdo:100015984.

Organism-specific databases

CTDi80201.

Phylogenomic databases

GeneTreeiENSGT00390000017159.
InParanoidiH9H6E5.
KOiK00844.
OMAiMCYMEEM.
OrthoDBiEOG7S21X5.
TreeFamiTF314238.

Family and domain databases

InterProiIPR001312. Hexokinase.
IPR019807. Hexokinase_BS.
IPR022673. Hexokinase_C.
IPR022672. Hexokinase_N.
[Graphical view]
PANTHERiPTHR19443. PTHR19443. 1 hit.
PfamiPF00349. Hexokinase_1. 2 hits.
PF03727. Hexokinase_2. 2 hits.
[Graphical view]
PROSITEiPS00378. HEXOKINASE_1. 1 hit.
PS51748. HEXOKINASE_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences."
    Mikkelsen T.S., Wakefield M.J., Aken B., Amemiya C.T., Chang J.L., Duke S., Garber M., Gentles A.J., Goodstadt L., Heger A., Jurka J., Kamal M., Mauceli E., Searle S.M., Sharpe T., Baker M.L., Batzer M.A., Benos P.V.
    , Belov K., Clamp M., Cook A., Cuff J., Das R., Davidow L., Deakin J.E., Fazzari M.J., Glass J.L., Grabherr M., Greally J.M., Gu W., Hore T.A., Huttley G.A., Kleber M., Jirtle R.L., Koina E., Lee J.T., Mahony S., Marra M.A., Miller R.D., Nicholls R.D., Oda M., Papenfuss A.T., Parra Z.E., Pollock D.D., Ray D.A., Schein J.E., Speed T.P., Thompson K., VandeBerg J.L., Wade C.M., Walker J.A., Waters P.D., Webber C., Weidman J.R., Xie X., Zody M.C., Baldwin J., Abdouelleil A., Abdulkadir J., Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A., An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P., Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Bloom T., Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A., Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M., Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G., DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M., Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S., Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D., Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T., Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B., Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L., Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D., Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F., LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T., Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V., Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J., Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V., Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T., Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B., Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P., Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C., Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L., Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N., Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T., Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T., Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J., Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A., Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C., Gnerre S., MacCallum I., Graves J.A., Ponting C.P., Breen M., Samollow P.B., Lander E.S., Lindblad-Toh K.
    Nature 447:167-177(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (MAR-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH9H6E5_MONDO
AccessioniPrimary (citable) accession number: H9H6E5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: January 9, 2013
Last modified: June 24, 2015
This is version 22 of the entry and version 2 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.