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Protein

Purine nucleoside phosphorylase

Gene

PNP

Organism
Anolis carolinensis (Green anole) (American chameleon)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.UniRule annotation

Catalytic activityi

Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi: purine nucleoside salvage

This protein is involved in the pathway purine nucleoside salvage, which is part of Purine metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway purine nucleoside salvage and in Purine metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei37PhosphateUniRule annotation1
Binding sitei68PhosphateUniRule annotation1
Binding sitei120Phosphate; via amide nitrogenUniRule annotation1
Binding sitei205Purine nucleosideUniRule annotation1
Binding sitei224PhosphateUniRule annotation1
Binding sitei247Purine nucleosideUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotation, Transferase

Enzyme and pathway databases

UniPathwayiUPA00606

Names & Taxonomyi

Protein namesi
Recommended name:
Purine nucleoside phosphorylaseUniRule annotation (EC:2.4.2.1UniRule annotation)
Alternative name(s):
Inosine-guanosine phosphorylaseUniRule annotation
Gene namesi
Name:PNPImported
OrganismiAnolis carolinensis (Green anole) (American chameleon)Imported
Taxonomic identifieri28377 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaIguaniaDactyloidaeAnolis
Proteomesi
  • UP000001646 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Expressioni

Gene expression databases

BgeeiENSACAG00000008033

Interactioni

Protein-protein interaction databases

STRINGi28377.ENSACAP00000007893

Structurei

3D structure databases

ProteinModelPortaliH9GDE3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini30 – 280PNP_UDP_1InterPro annotationAdd BLAST251

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 90Phosphate bindingUniRule annotation3

Sequence similaritiesi

Belongs to the PNP/MTAP phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG3984 Eukaryota
COG0005 LUCA
GeneTreeiENSGT00550000074740
InParanoidiH9GDE3
KOiK03783
OrthoDBiEOG091G0GEE
TreeFamiTF300049

Family and domain databases

InterProiView protein in InterPro
IPR000845 Nucleoside_phosphorylase_d
IPR035994 Nucleoside_phosphorylase_sf
IPR011270 Pur_Nuc_Pase_Ino/Guo-sp
IPR011268 Purine_phosphorylase
PANTHERiPTHR11904 PTHR11904, 1 hit
PfamiView protein in Pfam
PF01048 PNP_UDP_1, 1 hit
PIRSFiPIRSF000477 PurNPase, 1 hit
SUPFAMiSSF53167 SSF53167, 1 hit
TIGRFAMsiTIGR01700 PNPH, 1 hit
TIGR01697 PNPH-PUNA-XAPA, 1 hit

Sequencei

Sequence statusi: Complete.

H9GDE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSKREERYT YEDVKKTADW LLSKTKHRPK IAIICGSGLG GLADLLKDQV
60 70 80 90 100
AFEYSKIPNF PQSTVVGHAG RLVFGNLSGA PCVVMQGRFH MYEGYPLWKV
110 120 130 140 150
TFPVRIFHLL GVETLIVTNA AGGLNPDYKV GDIMVIRDHI NMPGFAGQNP
160 170 180 190 200
LMGPNDERFG ARFPAMSDAY DQDVRKLAHT VASEMGCSGC VREGVYVALG
210 220 230 240 250
GPNYETIAEC RFLQRLGADA VGMSTVPEVI VARHCGIRVF GFSLITNKAI
260 270 280 290
LDYETKEKAN HAEVLEASRQ SARTLEKLVS LMVQRIERNN NVA
Length:293
Mass (Da):32,353
Last modified:June 26, 2013 - v2
Checksum:i4E6A6EF3EFCFBD59
GO

Sequence databases

RefSeqiXP_003223917.1, XM_003223869.3

Genome annotation databases

EnsembliENSACAT00000008059; ENSACAP00000007893; ENSACAG00000008033
GeneIDi100567275
KEGGiacs:100567275

Similar proteinsi

Entry informationi

Entry nameiH9GDE3_ANOCA
AccessioniPrimary (citable) accession number: H9GDE3
Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: June 26, 2013
Last modified: March 28, 2018
This is version 40 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health