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Protein
Submitted name:

Neuroendocrine convertase 2 isoform 1 preproprotein

Gene

PCSK2

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. serine-type endopeptidase activity Source: Ensembl

GO - Biological processi

  1. enkephalin processing Source: Ensembl
  2. insulin processing Source: Ensembl
  3. nervous system development Source: Ensembl
  4. protein autoprocessing Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine proteaseUniRule annotationSAAS annotation

Protein family/group databases

MEROPSiS08.073.

Names & Taxonomyi

Protein namesi
Submitted name:
Neuroendocrine convertase 2 isoform 1 preproproteinImported
Gene namesi
Name:PCSK2Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiH9FVD3. baseline.

Structurei

3D structure databases

ProteinModelPortaliH9FVD3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S8 family.UniRule annotation
Contains peptidase S8 domain.SAAS annotation
Contains peptidase Sdomain.SAAS annotation

Phylogenomic databases

KOiK01360.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H9FVD3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGGCVSQWK AAAGFLFCVM VFASAERPVF TNHFLVELHK GGEDEARQVA
60 70 80 90 100
AEHGFGVRKL PFAEGLYHFY HNGLAKAKRR RSLHHKQQLE RDPRVKMALQ
110 120 130 140 150
QEGFDRKKRG YRDINEIDIN MNDPLFTKQW YLINTGQADG TPGLDLNVAE
160 170 180 190 200
AWELGYTGKG VTIGIMDDGI DYLHPDLASN YNAEASYDFS SNDPYPYPRY
210 220 230 240 250
TDDWFNSHGT RCAGEVSAAA NNNICGVGVA YNSKVAGIRM LDQPFMTDII
260 270 280 290 300
EASSISHMPQ LIDIYSASWG PTDNGKTVDG PRELTLQAMA DGVNKGRGGK
310 320 330 340 350
GSIYVWASGD GGSYDDCNCD GYASSMWTIS INSAINDGRT ALYDESCSST
360 370 380 390 400
LASTFSNGRK RNPEAGVATT DLYGNCTLRH SGTSAAAPEA AGVFALALEA
410 420 430 440 450
NLGLTWRDMQ HLTVLTSKRN QLHDEVHQWR RNGVGLEFNH LFGYGVLDAG
460 470 480 490 500
AMVKMAKDWK TVPERFHCVG GSVQDPEKIP STGKLVLTLT TDACEGKENF
510 520 530 540 550
VRYLEHVQAV ITVNATRRGD LNINMTSPMG TKSILLSRRP RDDDSKVGFD
560 570 580 590 600
KWPFMTTHTW GEDARGTWTL ELGFVGSAPQ KGVLKEWTLM LHGTQSAPYI
610 620 630
DQVVRDYQSK LAMSKKEELE EELDEAVERS LKSILSKN
Length:638
Mass (Da):70,539
Last modified:May 16, 2012 - v1
Checksum:i789B1CDEFD32F396
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JU334839 mRNA. Translation: AFE78592.1.
RefSeqiNP_001252954.1. NM_001266025.1.
UniGeneiMmu.34008.

Genome annotation databases

GeneIDi695730.
KEGGimcc:695730.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JU334839 mRNA. Translation: AFE78592.1.
RefSeqiNP_001252954.1. NM_001266025.1.
UniGeneiMmu.34008.

3D structure databases

ProteinModelPortaliH9FVD3.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

MEROPSiS08.073.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi695730.
KEGGimcc:695730.

Organism-specific databases

CTDi5126.

Phylogenomic databases

KOiK01360.

Gene expression databases

ExpressionAtlasiH9FVD3. baseline.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR008979. Galactose-bd-like.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: CaudateImported.

Entry informationi

Entry nameiH9FVD3_MACMU
AccessioniPrimary (citable) accession number: H9FVD3
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: February 4, 2015
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.