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Protein
Submitted name:

Histone deacetylase 6

Gene

HDAC6

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. core promoter binding Source: Ensembl
  2. histone deacetylase activity Source: Ensembl
  3. tubulin deacetylase activity Source: Ensembl
  4. zinc ion binding Source: InterPro

GO - Biological processi

  1. aggresome assembly Source: Ensembl
  2. cellular response to hydrogen peroxide Source: Ensembl
  3. cellular response to misfolded protein Source: Ensembl
  4. Hsp90 deacetylation Source: Ensembl
  5. lysosome localization Source: Ensembl
  6. macroautophagy Source: Ensembl
  7. misfolded or incompletely synthesized protein catabolic process Source: Ensembl
  8. negative regulation of microtubule depolymerization Source: Ensembl
  9. negative regulation of proteolysis Source: Ensembl
  10. peptidyl-lysine deacetylation Source: Ensembl
  11. polyubiquitinated misfolded protein transport Source: Ensembl
  12. positive regulation of chaperone-mediated protein complex assembly Source: Ensembl
  13. positive regulation of epithelial cell migration Source: Ensembl
  14. positive regulation of hydrogen peroxide-mediated programmed cell death Source: Ensembl
  15. positive regulation of receptor biosynthetic process Source: Ensembl
  16. positive regulation of signal transduction Source: Ensembl
  17. protein complex disassembly Source: Ensembl
  18. protein polyubiquitination Source: Ensembl
  19. regulation of establishment of protein localization Source: Ensembl
  20. regulation of fat cell differentiation Source: Ensembl
  21. regulation of gene expression, epigenetic Source: Ensembl
  22. regulation of receptor activity Source: Ensembl
  23. response to growth factor Source: Ensembl
  24. response to toxic substance Source: Ensembl
  25. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Histone deacetylase 6Imported
Gene namesi
Name:HDAC6Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

  1. aggresome Source: Ensembl
  2. axon Source: Ensembl
  3. caveola Source: Ensembl
  4. cell leading edge Source: Ensembl
  5. cytoplasmic microtubule Source: Ensembl
  6. cytosol Source: Ensembl
  7. dendrite Source: Ensembl
  8. dynein complex Source: Ensembl
  9. histone deacetylase complex Source: Ensembl
  10. perikaryon Source: Ensembl
  11. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

ExpressionAtlasiH9ER82. baseline.

Structurei

3D structure databases

ProteinModelPortaliH9ER82.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK11407.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H9ER82-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV
60 70 80 90 100
KKKGKMKKLG QAMEEDLIAG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL
110 120 130 140 150
WDDSFPEGPE RLHAIKEQLI QEGLLDRCVS FQARFAEKEE LMLVHSLEYI
160 170 180 190 200
DLMETTQYMN EGELRVLADT YDSVYLHPNS YSCACLASGS VLRLVDAVLG
210 220 230 240 250
AEIRNGMAII RPPGHHAQHS LMDGYCMFNH VAVAARYAQQ KHRIRRVLIV
260 270 280 290 300
DWDVHHGQGT QFTFDQDPSV LYFSIHRYEQ GRFWPHLKAS NWSTTGFGQG
310 320 330 340 350
QGYTINVPWN QVGMRDADYI AAFLHVLLPV ALEFQPQLVL VAAGFDALQG
360 370 380 390 400
DPKGEMAATP AGFAQLTHLL MGLAGGKLIL SLEGGYNLRA LAEGVSASLH
410 420 430 440 450
TLLGDPCPML ESPGAPCRSA QASVSCALEA LEPFWEVLVR STETVEGDNM
460 470 480 490 500
EEDNVEENEE EGPWEPPVLP ILTWPVLQSR TGLVYDQSMM NHCNLWDSHH
510 520 530 540 550
PEVPQRILRI MCRLEELGLA GRCLTLTPRP ATEAELLTCH SAEYVGHLRA
560 570 580 590 600
TEKMKTRELH RESSNFDSIY ICPSTFACAQ LATGAACRLV EAVLSGEVLN
610 620 630 640 650
GAAVVRPPGH HAEQDAACGF CFFNSVAVAA RHAQAISGRA LRILIVDWDV
660 670 680 690 700
HHGNGTQHMF EDDPSVLYVS LHRYDHGTFF PMGDEGASSQ IGRAAGTGFT
710 720 730 740 750
VNVAWNGPRM GDADYLAAWH RLVLPIAYEF NPELVLVSAG FDAARGDPLG
760 770 780 790 800
GCQVSPEGYA HLTHLLMGLA SGRIILILEG GYNLTSISES MAACTRSLLG
810 820 830 840 850
DPPPLLTLPR PPLSGALASI TETIQVHRRY WRSLRVMKVE DREGPSSSKL
860 870 880 890 900
VTKKAPQPAK PRLAERMTTR EKKVLEAGMG KITSASSGEE STPGQTKSET
910 920 930 940 950
AVVALTQDQS SEAATGGATL AQTISEAAVG GAMLGQTTSE EAVGGATPDQ
960 970 980 990 1000
TTSEKTVGGA TLDQTTSEDA VGGATLGQTT SEEAVGGATL AQTTSEAAME
1010 1020 1030 1040 1050
GATLDQTTSE EAPGGTELIQ TPLASSTDHQ TPPTSPVQGT TPQISPSTLI
1060 1070 1080 1090 1100
ENLRTLELGS KSQGASESQA PGEENLLGEA AGGQDMADSM LMQGSRGLTD
1110 1120 1130 1140 1150
QAIFYAVTPL PWCPHLVAVC PIPAAGLDVT QPCGDCGTIQ ENWVCLSCYQ
1160 1170 1180 1190 1200
VYCGRYINGH MLQHHENSGH PLVLSYIDLS TWCYYCQAYV HHQALLDVKN
1210
IAHQNKFGED MPHPH
Length:1,215
Mass (Da):131,412
Last modified:May 15, 2012 - v1
Checksum:iDD23286D7F9BB55D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JU321135 mRNA. Translation: AFE64891.1.
JU471169 mRNA. Translation: AFH27973.1.
JV044120 mRNA. Translation: AFI34191.1.
RefSeqiNP_001181125.1. NM_001194196.1.
UniGeneiMmu.18720.

Genome annotation databases

GeneIDi711363.
KEGGimcc:711363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JU321135 mRNA. Translation: AFE64891.1.
JU471169 mRNA. Translation: AFH27973.1.
JV044120 mRNA. Translation: AFI34191.1.
RefSeqiNP_001181125.1. NM_001194196.1.
UniGeneiMmu.18720.

3D structure databases

ProteinModelPortaliH9ER82.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi711363.
KEGGimcc:711363.

Organism-specific databases

CTDi10013.

Phylogenomic databases

KOiK11407.

Gene expression databases

ExpressionAtlasiH9ER82. baseline.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: CaudateImported, TestisImported and ThymusImported.

Entry informationi

Entry nameiH9ER82_MACMU
AccessioniPrimary (citable) accession number: H9ER82
Entry historyi
Integrated into UniProtKB/TrEMBL: May 15, 2012
Last sequence update: May 15, 2012
Last modified: March 3, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.