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H9ER82

- H9ER82_MACMU

UniProt

H9ER82 - H9ER82_MACMU

Protein
Submitted name:

Histone deacetylase 6

Gene

HDAC6

Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (16 May 2012)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. histone deacetylase activity Source: Ensembl
    2. tubulin deacetylase activity Source: Ensembl
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. aggresome assembly Source: Ensembl
    2. cellular response to hydrogen peroxide Source: Ensembl
    3. cellular response to misfolded protein Source: Ensembl
    4. Hsp90 deacetylation Source: Ensembl
    5. lysosome localization Source: Ensembl
    6. macroautophagy Source: Ensembl
    7. misfolded or incompletely synthesized protein catabolic process Source: Ensembl
    8. negative regulation of microtubule depolymerization Source: Ensembl
    9. negative regulation of proteolysis Source: Ensembl
    10. peptidyl-lysine deacetylation Source: Ensembl
    11. polyubiquitinated misfolded protein transport Source: Ensembl
    12. positive regulation of chaperone-mediated protein complex assembly Source: Ensembl
    13. positive regulation of epithelial cell migration Source: Ensembl
    14. positive regulation of hydrogen peroxide-mediated programmed cell death Source: Ensembl
    15. positive regulation of receptor biosynthetic process Source: Ensembl
    16. positive regulation of signal transduction Source: Ensembl
    17. protein complex disassembly Source: Ensembl
    18. protein polyubiquitination Source: Ensembl
    19. regulation of establishment of protein localization Source: Ensembl
    20. regulation of receptor activity Source: Ensembl
    21. response to growth factor Source: Ensembl
    22. response to toxic substance Source: Ensembl
    23. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: Ensembl

    Keywords - Molecular functioni

    HydrolaseSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Histone deacetylase 6Imported
    Gene namesi
    Name:HDAC6Imported
    OrganismiMacaca mulatta (Rhesus macaque)Imported
    Taxonomic identifieri9544 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

    Subcellular locationi

    GO - Cellular componenti

    1. aggresome Source: Ensembl
    2. caveola Source: Ensembl
    3. cell leading edge Source: Ensembl
    4. cytoplasmic microtubule Source: Ensembl
    5. cytosol Source: Ensembl
    6. dynein complex Source: Ensembl
    7. histone deacetylase complex Source: Ensembl
    8. perinuclear region of cytoplasm Source: Ensembl

    Structurei

    3D structure databases

    ProteinModelPortaliH9ER82.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    KOiK11407.

    Family and domain databases

    Gene3Di3.30.40.10. 1 hit.
    3.40.800.20. 2 hits.
    InterProiIPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 2 hits.
    PF02148. zf-UBP. 1 hit.
    [Graphical view]
    PRINTSiPR01270. HDASUPER.
    SMARTiSM00290. ZnF_UBP. 1 hit.
    [Graphical view]
    PROSITEiPS50271. ZF_UBP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H9ER82-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV     50
    KKKGKMKKLG QAMEEDLIAG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL 100
    WDDSFPEGPE RLHAIKEQLI QEGLLDRCVS FQARFAEKEE LMLVHSLEYI 150
    DLMETTQYMN EGELRVLADT YDSVYLHPNS YSCACLASGS VLRLVDAVLG 200
    AEIRNGMAII RPPGHHAQHS LMDGYCMFNH VAVAARYAQQ KHRIRRVLIV 250
    DWDVHHGQGT QFTFDQDPSV LYFSIHRYEQ GRFWPHLKAS NWSTTGFGQG 300
    QGYTINVPWN QVGMRDADYI AAFLHVLLPV ALEFQPQLVL VAAGFDALQG 350
    DPKGEMAATP AGFAQLTHLL MGLAGGKLIL SLEGGYNLRA LAEGVSASLH 400
    TLLGDPCPML ESPGAPCRSA QASVSCALEA LEPFWEVLVR STETVEGDNM 450
    EEDNVEENEE EGPWEPPVLP ILTWPVLQSR TGLVYDQSMM NHCNLWDSHH 500
    PEVPQRILRI MCRLEELGLA GRCLTLTPRP ATEAELLTCH SAEYVGHLRA 550
    TEKMKTRELH RESSNFDSIY ICPSTFACAQ LATGAACRLV EAVLSGEVLN 600
    GAAVVRPPGH HAEQDAACGF CFFNSVAVAA RHAQAISGRA LRILIVDWDV 650
    HHGNGTQHMF EDDPSVLYVS LHRYDHGTFF PMGDEGASSQ IGRAAGTGFT 700
    VNVAWNGPRM GDADYLAAWH RLVLPIAYEF NPELVLVSAG FDAARGDPLG 750
    GCQVSPEGYA HLTHLLMGLA SGRIILILEG GYNLTSISES MAACTRSLLG 800
    DPPPLLTLPR PPLSGALASI TETIQVHRRY WRSLRVMKVE DREGPSSSKL 850
    VTKKAPQPAK PRLAERMTTR EKKVLEAGMG KITSASSGEE STPGQTKSET 900
    AVVALTQDQS SEAATGGATL AQTISEAAVG GAMLGQTTSE EAVGGATPDQ 950
    TTSEKTVGGA TLDQTTSEDA VGGATLGQTT SEEAVGGATL AQTTSEAAME 1000
    GATLDQTTSE EAPGGTELIQ TPLASSTDHQ TPPTSPVQGT TPQISPSTLI 1050
    ENLRTLELGS KSQGASESQA PGEENLLGEA AGGQDMADSM LMQGSRGLTD 1100
    QAIFYAVTPL PWCPHLVAVC PIPAAGLDVT QPCGDCGTIQ ENWVCLSCYQ 1150
    VYCGRYINGH MLQHHENSGH PLVLSYIDLS TWCYYCQAYV HHQALLDVKN 1200
    IAHQNKFGED MPHPH 1215
    Length:1,215
    Mass (Da):131,412
    Last modified:May 16, 2012 - v1
    Checksum:iDD23286D7F9BB55D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JU321135 mRNA. Translation: AFE64891.1.
    JU471169 mRNA. Translation: AFH27973.1.
    JV044120 mRNA. Translation: AFI34191.1.
    RefSeqiNP_001181125.1. NM_001194196.1.
    UniGeneiMmu.18720.

    Genome annotation databases

    GeneIDi711363.
    KEGGimcc:711363.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JU321135 mRNA. Translation: AFE64891.1 .
    JU471169 mRNA. Translation: AFH27973.1 .
    JV044120 mRNA. Translation: AFI34191.1 .
    RefSeqi NP_001181125.1. NM_001194196.1.
    UniGenei Mmu.18720.

    3D structure databases

    ProteinModelPortali H9ER82.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 711363.
    KEGGi mcc:711363.

    Organism-specific databases

    CTDi 10013.

    Phylogenomic databases

    KOi K11407.

    Family and domain databases

    Gene3Di 3.30.40.10. 1 hit.
    3.40.800.20. 2 hits.
    InterProi IPR000286. His_deacetylse.
    IPR023801. His_deacetylse_dom.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR001607. Znf_UBP.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 2 hits.
    PF02148. zf-UBP. 1 hit.
    [Graphical view ]
    PRINTSi PR01270. HDASUPER.
    SMARTi SM00290. ZnF_UBP. 1 hit.
    [Graphical view ]
    PROSITEi PS50271. ZF_UBP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "De novo assembly of the rhesus macaque transcriptome from NextGen mRNA sequences."
      Pandey S., Maudhoo M.D., Guda C., Ferguson B., Fox H., Norgren R.B.
      Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: CaudateImported, TestisImported and ThymusImported.

    Entry informationi

    Entry nameiH9ER82_MACMU
    AccessioniPrimary (citable) accession number: H9ER82
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 16, 2012
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)