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H9ER82

- H9ER82_MACMU

UniProt

H9ER82 - H9ER82_MACMU

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Protein
Submitted name: Histone deacetylase 6
Gene
HDAC6
Organism
Macaca mulatta (Rhesus macaque)
Status
Unreviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. histone deacetylase activity Source: Ensembl
  2. tubulin deacetylase activity Source: Ensembl
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. Hsp90 deacetylation Source: Ensembl
  2. aggresome assembly Source: Ensembl
  3. cellular response to hydrogen peroxide Source: Ensembl
  4. cellular response to misfolded protein Source: Ensembl
  5. lysosome localization Source: Ensembl
  6. macroautophagy Source: Ensembl
  7. misfolded or incompletely synthesized protein catabolic process Source: Ensembl
  8. negative regulation of microtubule depolymerization Source: Ensembl
  9. negative regulation of proteolysis Source: Ensembl
  10. peptidyl-lysine deacetylation Source: Ensembl
  11. polyubiquitinated misfolded protein transport Source: Ensembl
  12. positive regulation of chaperone-mediated protein complex assembly Source: Ensembl
  13. positive regulation of epithelial cell migration Source: Ensembl
  14. positive regulation of hydrogen peroxide-mediated programmed cell death Source: Ensembl
  15. positive regulation of receptor biosynthetic process Source: Ensembl
  16. positive regulation of signal transduction Source: Ensembl
  17. protein complex disassembly Source: Ensembl
  18. protein polyubiquitination Source: Ensembl
  19. regulation of establishment of protein localization Source: Ensembl
  20. regulation of receptor activity Source: Ensembl
  21. response to growth factor Source: Ensembl
  22. response to toxic substance Source: Ensembl
  23. ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseSAAS annotations

Names & Taxonomyi

Protein namesi
Submitted name:
Histone deacetylase 6Imported
Gene namesi
Name:HDAC6Imported
OrganismiMacaca mulatta (Rhesus macaque)Imported
Taxonomic identifieri9544 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniCercopithecidaeCercopithecinaeMacaca

Subcellular locationi

GO - Cellular componenti

  1. aggresome Source: Ensembl
  2. caveola Source: Ensembl
  3. cell leading edge Source: Ensembl
  4. cytoplasmic microtubule Source: Ensembl
  5. cytosol Source: Ensembl
  6. dynein complex Source: Ensembl
  7. histone deacetylase complex Source: Ensembl
  8. perinuclear region of cytoplasm Source: Ensembl
Complete GO annotation...

Structurei

3D structure databases

ProteinModelPortaliH9ER82.

Family & Domainsi

Phylogenomic databases

KOiK11407.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
SMARTiSM00290. ZnF_UBP. 1 hit.
[Graphical view]
PROSITEiPS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H9ER82-1 [UniParc]FASTAAdd to Basket

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MTSTGQDSTT TRQRRSRQNP QSPPQDSSVT SKRNIKKGAV PRSIPNLAEV     50
KKKGKMKKLG QAMEEDLIAG LQGMDLNLEA EALAGTGLVL DEQLNEFHCL 100
WDDSFPEGPE RLHAIKEQLI QEGLLDRCVS FQARFAEKEE LMLVHSLEYI 150
DLMETTQYMN EGELRVLADT YDSVYLHPNS YSCACLASGS VLRLVDAVLG 200
AEIRNGMAII RPPGHHAQHS LMDGYCMFNH VAVAARYAQQ KHRIRRVLIV 250
DWDVHHGQGT QFTFDQDPSV LYFSIHRYEQ GRFWPHLKAS NWSTTGFGQG 300
QGYTINVPWN QVGMRDADYI AAFLHVLLPV ALEFQPQLVL VAAGFDALQG 350
DPKGEMAATP AGFAQLTHLL MGLAGGKLIL SLEGGYNLRA LAEGVSASLH 400
TLLGDPCPML ESPGAPCRSA QASVSCALEA LEPFWEVLVR STETVEGDNM 450
EEDNVEENEE EGPWEPPVLP ILTWPVLQSR TGLVYDQSMM NHCNLWDSHH 500
PEVPQRILRI MCRLEELGLA GRCLTLTPRP ATEAELLTCH SAEYVGHLRA 550
TEKMKTRELH RESSNFDSIY ICPSTFACAQ LATGAACRLV EAVLSGEVLN 600
GAAVVRPPGH HAEQDAACGF CFFNSVAVAA RHAQAISGRA LRILIVDWDV 650
HHGNGTQHMF EDDPSVLYVS LHRYDHGTFF PMGDEGASSQ IGRAAGTGFT 700
VNVAWNGPRM GDADYLAAWH RLVLPIAYEF NPELVLVSAG FDAARGDPLG 750
GCQVSPEGYA HLTHLLMGLA SGRIILILEG GYNLTSISES MAACTRSLLG 800
DPPPLLTLPR PPLSGALASI TETIQVHRRY WRSLRVMKVE DREGPSSSKL 850
VTKKAPQPAK PRLAERMTTR EKKVLEAGMG KITSASSGEE STPGQTKSET 900
AVVALTQDQS SEAATGGATL AQTISEAAVG GAMLGQTTSE EAVGGATPDQ 950
TTSEKTVGGA TLDQTTSEDA VGGATLGQTT SEEAVGGATL AQTTSEAAME 1000
GATLDQTTSE EAPGGTELIQ TPLASSTDHQ TPPTSPVQGT TPQISPSTLI 1050
ENLRTLELGS KSQGASESQA PGEENLLGEA AGGQDMADSM LMQGSRGLTD 1100
QAIFYAVTPL PWCPHLVAVC PIPAAGLDVT QPCGDCGTIQ ENWVCLSCYQ 1150
VYCGRYINGH MLQHHENSGH PLVLSYIDLS TWCYYCQAYV HHQALLDVKN 1200
IAHQNKFGED MPHPH 1215
Length:1,215
Mass (Da):131,412
Last modified:May 16, 2012 - v1
Checksum:iDD23286D7F9BB55D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JU321135 mRNA. Translation: AFE64891.1.
JU471169 mRNA. Translation: AFH27973.1.
JV044120 mRNA. Translation: AFI34191.1.
RefSeqiNP_001181125.1. NM_001194196.1.
UniGeneiMmu.18720.

Genome annotation databases

GeneIDi711363.
KEGGimcc:711363.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
JU321135 mRNA. Translation: AFE64891.1 .
JU471169 mRNA. Translation: AFH27973.1 .
JV044120 mRNA. Translation: AFI34191.1 .
RefSeqi NP_001181125.1. NM_001194196.1.
UniGenei Mmu.18720.

3D structure databases

ProteinModelPortali H9ER82.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 711363.
KEGGi mcc:711363.

Organism-specific databases

CTDi 10013.

Phylogenomic databases

KOi K11407.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
SMARTi SM00290. ZnF_UBP. 1 hit.
[Graphical view ]
PROSITEi PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "De novo assembly of the rhesus macaque transcriptome from NextGen mRNA sequences."
    Pandey S., Maudhoo M.D., Guda C., Ferguson B., Fox H., Norgren R.B.
    Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: CaudateImported, TestisImported and ThymusImported.

Entry informationi

Entry nameiH9ER82_MACMU
AccessioniPrimary (citable) accession number: H9ER82
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: April 16, 2014
This is version 16 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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