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H9C875

- H9C875_HUMAN

UniProt

H9C875 - H9C875_HUMAN

Protein
Submitted name:

Interleukin 6

Gene
N/A
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 5 out of 5- Protein predictedi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (16 May 2012)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. aging Source: Ensembl
    2. bone remodeling Source: Ensembl
    3. branching involved in salivary gland morphogenesis Source: Ensembl
    4. cell growth Source: Ensembl
    5. cell redox homeostasis Source: Ensembl
    6. defense response to protozoan Source: Ensembl
    7. endocrine pancreas development Source: Ensembl
    8. epithelial cell proliferation involved in salivary gland morphogenesis Source: Ensembl
    9. glucagon secretion Source: Ensembl
    10. immune response Source: InterPro
    11. interleukin-6-mediated signaling pathway Source: Ensembl
    12. muscle cell cellular homeostasis Source: Ensembl
    13. negative regulation of cell proliferation Source: Ensembl
    14. negative regulation of chemokine biosynthetic process Source: Ensembl
    15. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
    16. negative regulation of cytokine secretion Source: Ensembl
    17. negative regulation of gluconeogenesis Source: Ensembl
    18. negative regulation of hormone secretion Source: Ensembl
    19. negative regulation of muscle organ development Source: Ensembl
    20. negative regulation of neuron death Source: Ensembl
    21. negative regulation of protein kinase activity Source: Ensembl
    22. neutrophil apoptotic process Source: Ensembl
    23. positive regulation of DNA replication Source: Ensembl
    24. positive regulation of epithelial cell proliferation Source: Ensembl
    25. positive regulation of ERK1 and ERK2 cascade Source: Ensembl
    26. positive regulation of neuron differentiation Source: Ensembl
    27. positive regulation of nitric oxide biosynthetic process Source: Ensembl
    28. positive regulation of protein import into nucleus, translocation Source: Ensembl
    29. positive regulation of protein kinase B signaling Source: Ensembl
    30. positive regulation of T-helper 2 cell differentiation Source: Ensembl
    31. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    32. positive regulation of transmission of nerve impulse Source: Ensembl
    33. positive regulation of tyrosine phosphorylation of Stat3 protein Source: Ensembl
    34. regulation of cell shape Source: Ensembl
    35. regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
    36. response to amino acid Source: Ensembl
    37. response to antibiotic Source: Ensembl
    38. response to caffeine Source: Ensembl
    39. response to calcium ion Source: Ensembl
    40. response to cold Source: Ensembl
    41. response to drug Source: Ensembl
    42. response to electrical stimulus Source: Ensembl
    43. response to heat Source: Ensembl
    44. response to insulin Source: Ensembl
    45. response to lipopolysaccharide Source: Ensembl
    46. response to mechanical stimulus Source: Ensembl
    47. response to nutrient levels Source: Ensembl
    48. response to wounding Source: Ensembl
    49. T cell activation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Interleukin 6Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. extracellular space Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiH9C875.
    BgeeiH9C875.

    Family & Domainsi

    Family and domain databases

    Gene3Di1.20.1250.10. 1 hit.
    InterProiIPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR003574. IL-6.
    IPR003573. IL-6/IL-23/GCSF/MGF.
    [Graphical view]
    PANTHERiPTHR11457. PTHR11457. 1 hit.
    PfamiPF00489. IL6. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001935. IL6_MGF_GCSF. 1 hit.
    PRINTSiPR00433. IL6GCSFMGF.
    PR00434. INTERLEUKIN6.
    SMARTiSM00126. IL6. 1 hit.
    [Graphical view]
    SUPFAMiSSF47266. SSF47266. 1 hit.
    PROSITEiPS00254. INTERLEUKIN_6. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H9C875-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSFSTSAFG PVAFSLLLLV LPAAFPAPVP PGEDSKDVAA PHRQPLTSSE    50
    RIDKQIRYIL DGISALRKET CNKSNMCESS KEALAENNLN LPKMAEKDGC 100
    FQSGFNEETC LVKIITGLLE FEVYLEYLQN RFESSEEQAR AVQMSTKVLI 150
    QFLQKKAKNL DAITTPDPTT NASLLTKLQA QNQWLQDMTT HLILRSFKEF 200
    LQSSLRALRQ M 211
    Length:211
    Mass (Da):23,661
    Last modified:May 16, 2012 - v1
    Checksum:iFCD17C8F3B0DC982
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JQ250825 Genomic RNA. Translation: AFF18412.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    JQ250825 Genomic RNA. Translation: AFF18412.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    NextBioi 35530945.

    Gene expression databases

    ArrayExpressi H9C875.
    Bgeei H9C875.

    Family and domain databases

    Gene3Di 1.20.1250.10. 1 hit.
    InterProi IPR009079. 4_helix_cytokine-like_core.
    IPR012351. 4_helix_cytokine_core.
    IPR003574. IL-6.
    IPR003573. IL-6/IL-23/GCSF/MGF.
    [Graphical view ]
    PANTHERi PTHR11457. PTHR11457. 1 hit.
    Pfami PF00489. IL6. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001935. IL6_MGF_GCSF. 1 hit.
    PRINTSi PR00433. IL6GCSFMGF.
    PR00434. INTERLEUKIN6.
    SMARTi SM00126. IL6. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47266. SSF47266. 1 hit.
    PROSITEi PS00254. INTERLEUKIN_6. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evaluation of human Interleukin-6 expression from Pakistani Dengue patients and cloning of its gene."
      Kanwal F., Zaidi N.-u.-S.S., Javed F., Farooqi Z.-u.-R.
      Submitted (DEC-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiH9C875_HUMAN
    AccessioniPrimary (citable) accession number: H9C875
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 16, 2012
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.