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H8XPG1 (H8XPG1_FLAIG) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL CCG53235.1
Ordered Locus Names:KQS_06375 EMBL CCG53235.1
OrganismFlavobacterium indicum (strain DSM 17447 / CIP 109464 / GPTSA100-9) [Complete proteome] [HAMAP] EMBL CCG53235.1
Taxonomic identifier1094466 [NCBI]
Taxonomic lineageBacteriaBacteroidetesFlavobacteriiaFlavobacterialesFlavobacteriaceaeFlavobacterium

Protein attributes

Sequence length324 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain120 – 319200ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding148 – 20356ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2741Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2861Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2861Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2881Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
H8XPG1 [UniParc].

Last modified May 16, 2012. Version 1.
Checksum: 65E36E18BD1AE92C

FASTA32436,142
        10         20         30         40         50         60 
MTNVAIIMGG YSSEYKISLT SGNVVYNHLD ATKYNAYRIH IFKDKWVYVD KNEQEFPINK 

        70         80         90        100        110        120 
NDFSVEVQGS KITFDVVFNA IHGTPGEDGL MQAYFELLNI PQTSCDYYQA ALTFNKRDLL 

       130        140        150        160        170        180 
SVLKPYGIKT ATSFYLNNGD SIDITKIIET VGLPCFVKPN KSGSSFGISK VKSIEDLVPA 

       190        200        210        220        230        240 
IENAYKEDNE IIIESFLDGT EVSVGVINFK GQIKVLPITE IVSENDFFDY EAKYLGKSQE 

       250        260        270        280        290        300 
ITPARISAEI QAKVEATAKK AYEVLKMSGF SRSEFIIVNG EPHMLEMNTI PGLTTESILP 

       310        320 
QQAREAGISL NELFENAIEL ALKK 

« Hide

References

[1]"Complete genome sequence of Flavobacterium indicum GPTSA100-9T, isolated from warm spring water."
Barbier P., Houel A., Loux V., Poulain J., Bernardet J.-F., Touchon M., Duchaud E.
Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 17447 / CIP 109464 / GPTSA100-9.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
HE774682 Genomic DNA. Translation: CCG53235.1.
RefSeqYP_005357292.1. NC_017025.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID11987887.
KEGGfin:KQS_06375.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycFIND1094466:GLDB-1275-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH8XPG1_FLAIG
AccessionPrimary (citable) accession number: H8XPG1
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: February 19, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)