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H8NFJ6 (H8NFJ6_RICPO) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047
EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AFE53264.1
ORF Names:MA7_01210 EMBL AFE53264.1
OrganismRickettsia prowazekii str. RpGvF24 EMBL AFE53264.1
Taxonomic identifier1105099 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › typhus group ›

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS000291

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS000291

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS000291

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS000291

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS000291.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047 SAAS SAAS000291

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain121 – 315195ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding148 – 19952ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2681Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2841Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
H8NFJ6 [UniParc].

Last modified May 16, 2012. Version 1.
Checksum: B67B1A905B3B8CB4

FASTA32135,809
        10         20         30         40         50         60 
MHKYQTHFVE HSVVKILSST GKKHIALVAG GMSAEREVSL VSSAGVSKAL IELGYKVTFV 

        70         80         90        100        110        120 
DMGADIAVKL QEINPDIVFN CLHGTYGEDG CLPGLLNIMR IPYTHSGLLS SALAFDKIHF 

       130        140        150        160        170        180 
RSCVLKNNIN IADSIVVSKS DHINTDPMKR PYVIKPLKQG SSIGVEVIFE EDDFNFTDYD 

       190        200        210        220        230        240 
FPYGEDIIIE QYIQGQELQV ALLNGKALGV LEIKLLKNRF YDYETKYNEG FAEHVCPAPL 

       250        260        270        280        290        300 
PANLYKKLLI ESEKIYKTIN CKGPVRAEFI LEEQTNKLYV LEINTHPGMT PLSIVPEIAA 

       310        320 
YAGINFTNLI EEIIKMASFE S

« Hide

References

[1]Johnson S.L., Sims D., Han S., Bruce D.C., Dasch G.A.
Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: RpGvF24 EMBL AFE53264.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003396 Genomic DNA. Translation: AFE53264.1.
RefSeqYP_005413691.1. NC_017057.1.

3D structure databases

ProteinModelPortalH8NFJ6.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFE53264; AFE53264; MA7_01210.
GeneID12016770.
KEGGrpv:MA7_01210.

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycRPRO1105099:GLJJ-240-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. PreATP-grasp-like. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH8NFJ6_RICPO
AccessionPrimary (citable) accession number: H8NFJ6
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: May 29, 2013
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info