Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

H8NCK7 (H8NCK7_RICPO) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047 EMBL AFE52693.1
ORF Names:MA5_02575 EMBL AFE52693.1
OrganismRickettsia prowazekii str. GvV257 [Complete proteome] EMBL AFE52693.1
Taxonomic identifier1105098 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group

Protein attributes

Sequence length321 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS005905

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS005905

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS005905

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS005905.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS005905

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain121 – 315195ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding148 – 19952ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding2681Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding2821Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding2841Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
H8NCK7 [UniParc].

Last modified May 16, 2012. Version 1.
Checksum: B67B1A905B3B8CB4

FASTA32135,809
        10         20         30         40         50         60 
MHKYQTHFVE HSVVKILSST GKKHIALVAG GMSAEREVSL VSSAGVSKAL IELGYKVTFV 

        70         80         90        100        110        120 
DMGADIAVKL QEINPDIVFN CLHGTYGEDG CLPGLLNIMR IPYTHSGLLS SALAFDKIHF 

       130        140        150        160        170        180 
RSCVLKNNIN IADSIVVSKS DHINTDPMKR PYVIKPLKQG SSIGVEVIFE EDDFNFTDYD 

       190        200        210        220        230        240 
FPYGEDIIIE QYIQGQELQV ALLNGKALGV LEIKLLKNRF YDYETKYNEG FAEHVCPAPL 

       250        260        270        280        290        300 
PANLYKKLLI ESEKIYKTIN CKGPVRAEFI LEEQTNKLYV LEINTHPGMT PLSIVPEIAA 

       310        320 
YAGINFTNLI EEIIKMASFE S 

« Hide

References

[1]Johnson S.L., Sims D., Han S., Bruce D.C., Dasch G.A.
Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: GvV257 EMBL AFE52693.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003395 Genomic DNA. Translation: AFE52693.1.
RefSeqYP_005404771.1. NC_017048.1.

3D structure databases

ProteinModelPortalH8NCK7.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFE52693; AFE52693; MA5_02575.
GeneID12007399.
KEGGrpg:MA5_02575.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycRPRO1105098:GLJG-511-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 2 hits.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH8NCK7_RICPO
AccessionPrimary (citable) accession number: H8NCK7
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: February 19, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)