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H8N2K8

- H8N2K8_RICPO

UniProt

H8N2K8 - H8N2K8_RICPO

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Protein

Alanine racemase

Gene

alr

Organism
Rickettsia prowazekii str. Chernikova
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

Note: Pyridoxal phosphate.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei34 – 341Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei133 – 1331SubstrateUniRule annotation
Active sitei298 – 2981Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei346 – 3461Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRPRO1105094:GLJE-89-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Name:alrImported
ORF Names:M9W_00450Imported
OrganismiRickettsia prowazekii str. ChernikovaImported
Taxonomic identifieri1105094 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiatyphus group
ProteomesiUP000007586: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei34 – 341N6-(pyridoxal phosphate)lysineUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliH8N2K8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
IPR005728. Rickett_RPE.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01045. RPE1. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8N2K8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLCTLEINL SAIKNNYRLL QDICKTALVG AVVKANGYGL GAMQIAKALI
60 70 80 90 100
KENCQYFFVA TSEEGINLRK VLNNDITILV LNGVFTHDAL ELIQYNLTPV
110 120 130 140 150
LNNLSQIEIW QKFSNLKGKI LPCYLHFNTG LNRFGLNSDE IEQLINDRDL
160 170 180 190 200
LKGLDLQYII SHLAASEETG NPYNLIQLNR FKVYLEYFPN VKASFANSGG
210 220 230 240 250
IFLGQDYHFD LARPGAALYG LNSLIEVSSN LSYTEEFESN TAALTTTACI
260 270 280 290 300
NKCPDVSVRL TPKLPLKGSY TVRLQNPVTL KAPIIDLQNL TLDSHIGYNM
310 320 330 340 350
TFTTKRDSVI ATLPLGYADG FSRNFSSQGE VFINSCRVPI VGRVSMDLIN
360 370 380 390 400
IDVTDLPPSE VFLGQEAEII GNYCTPDKIA SIIGTIGYEV LTSLGSRYKR

KYIS
Length:404
Mass (Da):44,799
Last modified:May 16, 2012 - v1
Checksum:i0BA23D87D832576B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003391 Genomic DNA. Translation: AFE48919.1.
RefSeqiYP_005405197.1. NC_017049.1.

Genome annotation databases

EnsemblBacteriaiAFE48919; AFE48919; M9W_00450.
GeneIDi12007843.
KEGGirpw:M9W_00450.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003391 Genomic DNA. Translation: AFE48919.1 .
RefSeqi YP_005405197.1. NC_017049.1.

3D structure databases

ProteinModelPortali H8N2K8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFE48919 ; AFE48919 ; M9W_00450 .
GeneIDi 12007843.
KEGGi rpw:M9W_00450.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci RPRO1105094:GLJE-89-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
IPR005728. Rickett_RPE.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01045. RPE1. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Johnson S.L., Munk A.C., Han S., Bruce D.C., Dasch G.A.
    Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ChernikovaImported.

Entry informationi

Entry nameiH8N2K8_RICPO
AccessioniPrimary (citable) accession number: H8N2K8
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: November 26, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3