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Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Enterococcus faecium (strain Aus0004)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotation

Catalytic activityi

2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

Pathway: glycolysis

This protein is involved in step 3 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk), Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (EFAU004_01291)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei8 – 81Tele-phosphohistidine intermediateUniRule annotation
Binding sitei14 – 1412-phospho-D-glycerateUniRule annotation
Binding sitei59 – 5912-phospho-D-glycerateUniRule annotation
Binding sitei97 – 9712-phospho-D-glycerateUniRule annotation
Active sitei176 – 1761UniRule annotation
Binding sitei178 – 17812-phospho-D-glycerateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Biological processi

GlycolysisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciEFAE1155766:GLCU-1591-MONOMER.
UniPathwayiUPA00109; UER00186.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
Short name:
BPG-dependent PGAMUniRule annotation
Short name:
PGAMUniRule annotation
Short name:
PhosphoglyceromutaseUniRule annotation
Short name:
dPGMUniRule annotation
Gene namesi
Name:gpmAUniRule annotation
Ordered Locus Names:EFAU004_01564Imported
OrganismiEnterococcus faecium (strain Aus0004)Imported
Taxonomic identifieri1155766 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000007591 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliH8L8W1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni20 – 2122-phospho-D-glycerate bindingUniRule annotation
Regioni86 – 8942-phospho-D-glycerate bindingUniRule annotation
Regioni113 – 11422-phospho-D-glycerate bindingUniRule annotation

Sequence similaritiesi

Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotation

Phylogenomic databases

KOiK01834.
OMAiDNIFTGW.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8L8W1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLVLLRHGE SEANFENYWT GWLDVALTEK GKEQAAVAGQ KMLEAGLQFD
60 70 80 90 100
AVYTSVLKRA ILTGQVALEE MGQLWLPIIK TWRLNERHYG DLVGKNKDKM
110 120 130 140 150
KEIYGKDQVK TWRRGYTEVP PLTAENRFDR RYDHLDPHLI PYGESLEMTV
160 170 180 190 200
NRIIPLWQDH LAPKLKDRQD LLVVGHGNSI RALTKYLEDV PEDQMDTIDI
210 220
PNAQPIQYTL ADDLTILDKK IL
Length:222
Mass (Da):25,637
Last modified:May 16, 2012 - v1
Checksum:i3A016FAFC147659A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003351 Genomic DNA. Translation: AFC63648.1.
RefSeqiWP_002295197.1. NC_017022.1.
YP_005354766.1. NC_017022.1.

Genome annotation databases

EnsemblBacteriaiAFC63648; AFC63648; EFAU004_01564.
KEGGiefc:EFAU004_01564.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003351 Genomic DNA. Translation: AFC63648.1.
RefSeqiWP_002295197.1. NC_017022.1.
YP_005354766.1. NC_017022.1.

3D structure databases

ProteinModelPortaliH8L8W1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFC63648; AFC63648; EFAU004_01564.
KEGGiefc:EFAU004_01564.

Phylogenomic databases

KOiK01834.
OMAiDNIFTGW.

Enzyme and pathway databases

UniPathwayiUPA00109; UER00186.
BioCyciEFAE1155766:GLCU-1591-MONOMER.

Family and domain databases

Gene3Di3.40.50.1240. 1 hit.
HAMAPiMF_01039. PGAM_GpmA.
InterProiIPR013078. His_Pase_superF_clade-1.
IPR029033. His_PPase_superfam.
IPR001345. PG/BPGM_mutase_AS.
IPR005952. Phosphogly_mut1.
[Graphical view]
PANTHERiPTHR11931. PTHR11931. 1 hit.
PfamiPF00300. His_Phos_1. 1 hit.
[Graphical view]
SMARTiSM00855. PGAM. 1 hit.
[Graphical view]
SUPFAMiSSF53254. SSF53254. 1 hit.
TIGRFAMsiTIGR01258. pgm_1. 1 hit.
PROSITEiPS00175. PG_MUTASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Aus0004Imported.

Entry informationi

Entry nameiH8L8W1_ENTFU
AccessioniPrimary (citable) accession number: H8L8W1
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: May 27, 2015
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.