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H8L038 (H8L038_FRAAD) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Fraau_1847 EMBL AFC86250.1
OrganismFrateuria aurantia (strain ATCC 33424 / DSM 6220 / NBRC 3245 / NCIMB 13370) (Acetobacter aurantius) [Complete proteome] [HAMAP] EMBL AFC86250.1
Taxonomic identifier767434 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeFrateuria

Protein attributes

Sequence length383 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain147 – 359213ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding176 – 23156ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3081Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3231Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3231Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3251Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
H8L038 [UniParc].

Last modified May 16, 2012. Version 1.
Checksum: F8C9C0E1D3C2D8AE

FASTA38341,269
        10         20         30         40         50         60 
MAAKTTVAVM FGGCSPEHDV SWESAAYVVA GLDRERHALV LIGIDRQGIW HLVNEEVLGV 

        70         80         90        100        110        120 
ADQARDEQLR QGQHVMLAPG GGGRLIYPDW TAAHRDLPRQ VDMVFPVLHG PGGEDGTLQG 

       130        140        150        160        170        180 
LLEQAAVAYV GNGVTASAAC MDKAVCRRLL HEAGLPVLPA LTLAAGQRLS YAQACLQLET 

       190        200        210        220        230        240 
SILMVKPVGQ GSSVGISKVE QASEFQAALE SARSYGPRVM IEPALARPRE LEIGMLERSD 

       250        260        270        280        290        300 
GHRQWSAVAE IELAPAYRFY SYQAKYMDAE AISLRLPAEL AEDVAARIRD LADRACQVLA 

       310        320        330        340        350        360 
CEGLARVDFL LSPAAGGMIY INEINTMPGL TRHSLFPALW RRQGCIDRQV IAMLLAHAER 

       370        380 
RHAAGADGTD RMAGYIPEAA GCG 

« Hide

References

[1]"The complete genome of Frateuria aurantia DSM 6220."
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Peters L., Ovchinnikova G., Teshima H., Kyrpides N., Mavromatis K., Ivanova N., Brettin T., Detter J.C., Han C. expand/collapse author list , Larimer F., Land M., Hauser L., Markowitz V., Cheng J.-F., Hugenholtz P., Woyke T., Wu D., Brambilla E., Klenk H.-P., Eisen J.A.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 33424 / DSM 6220 / NBRC 3245 / NCIMB 13370.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003350 Genomic DNA. Translation: AFC86250.1.
RefSeqYP_005377932.1. NC_017033.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFC86250; AFC86250; Fraau_1847.
GeneID11969732.
KEGGfau:Fraau_1847.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.
OMAGHILANI.

Enzyme and pathway databases

BioCycFAUR767434:GLDK-1847-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH8L038_FRAAD
AccessionPrimary (citable) accession number: H8L038
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: June 11, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)