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H8K3N8 (H8K3N8_RICAG) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
DNA mismatch repair protein MutL HAMAP-Rule MF_00149
Gene names
Name:mutL HAMAP-Rule MF_00149 EMBL AFC69132.1
Ordered Locus Names:MCE_00420 EMBL AFC69132.1
OrganismRickettsia amblyommii (strain GAT-30V) [Complete proteome] [HAMAP] EMBL AFC69132.1
Taxonomic identifier1105111 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group ›

Protein attributes

Sequence length610 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity. SAAS SAAS014762 HAMAP-Rule MF_00149

Sequence similarities

Belongs to the DNA mismatch repair MutL/HexB family. HAMAP-Rule MF_00149

Ontologies

Keywords
   Biological processDNA damage
DNA repair SAAS SAAS014762 HAMAP-Rule MF_00149
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processmismatch repair

Inferred from electronic annotation. Source: HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: InterPro

mismatched DNA binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
H8K3N8 [UniParc].

Last modified May 16, 2012. Version 1.
Checksum: 206900785384EE4F

FASTA61068,827
        10         20         30         40         50         60 
MTIKFLSESA INRIAAGEVI ERPASVVKEL VENAVDASST KIDIILERAG KNLIIISDDG 

        70         80         90        100        110        120 
IGMTDKELEI AVERHTTSKF DESDFLNIHT FGFRGEALPS IAAISKMLIT SKKRDADKAF 

       130        140        150        160        170        180 
QIKLIGGNEK QVTISVHNEG TKIEIRDLFF ATPARLKFLR ADKTELAATV DVVKKIALAH 

       190        200        210        220        230        240 
PKISFSLTHD GKNLLKLKGQ NKDAETNLKQ RIIDVIGDDF IKNAAYINFK TPDFSICGYT 

       250        260        270        280        290        300 
SSPTYNRASS EDQFLFINNR PVKDKLLQVA LRVAYQDYLA RDRYPLCAIF LQIDPQLVDV 

       310        320        330        340        350        360 
NVHPAKAEVR FHDPNYVRNL LIEAIKNALT NKSHVTSTTI ASDALELFKN PLVNKQSPVS 

       370        380        390        400        410        420 
KVINVNSKSA DYRPTTHSTL NTVPQNHVCQ KLIDTLSHAK IEQEVENRIE HEQQTRKQYK 

       430        440        450        460        470        480 
LGAAKAQLHT TYIISQTEDS IVITDQHAAH ERLGYEKIKD YLKTEELIKQ RLLIPEIVEL 

       490        500        510        520        530        540 
PNEKKADCLY DHREKLYKLG LTLEKFGEKS IIVTEIPNIL GDVNVQKLIQ DLADHLSDFG 

       550        560        570        580        590        600 
KNIALTELIE HVTETYACHY SIRAGQKLSA DEMNALLRQM ENTPLSGQCN HGRPTYIELK 

       610 
LKDIERLFGR

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References

[1]"Complete genome sequence of Candidatus Rickettsia amblyommii strain GAT-30V."
Johnson S.L., Munk A.C., Han S., Bruce D.C., Dasch G.A.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: GAT-30V.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003334 Genomic DNA. Translation: AFC69132.1.
RefSeqYP_005364764.1. NC_017028.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFC69132; AFC69132; MCE_00420.
GeneID11963281.
KEGGram:MCE_00420.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK03572.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
HAMAPMF_00149. DNA_mis_repair.
InterProIPR002099. DNA_mismatch_repair.
IPR013507. DNA_mismatch_repair_C.
IPR014762. DNA_mismatch_repair_CS.
IPR020667. DNA_mismatch_repair_MutL.
IPR014763. DNA_mismatch_repair_N.
IPR003594. HATPase_ATP-bd.
IPR014790. MutL_C.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERPTHR10073. PTHR10073. 1 hit.
PfamPF01119. DNA_mis_repair. 1 hit.
PF08676. MutL_C. 1 hit.
[Graphical view]
SMARTSM00387. HATPase_c. 1 hit.
SM00853. MutL_C. 1 hit.
[Graphical view]
SUPFAMSSF55874. ATP_bd_ATPase. 1 hit.
SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMsTIGR00585. mutl. 1 hit.
PROSITEPS00058. DNA_MISMATCH_REPAIR_1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH8K3N8_RICAG
AccessionPrimary (citable) accession number: H8K3N8
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: May 1, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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