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H8JW16

- H8JW16_VIBCL

UniProt

H8JW16 - H8JW16_VIBCL

Protein

Thymidine kinase

Gene

tdk

Organism
Vibrio cholerae IEC224
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (16 May 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei88 – 881Proton acceptorUniRule annotation
    Metal bindingi145 – 1451ZincUniRule annotation
    Metal bindingi147 – 1471ZincUniRule annotation
    Metal bindingi182 – 1821ZincUniRule annotation
    Metal bindingi185 – 1851ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi9 – 168ATPUniRule annotation
    Nucleotide bindingi87 – 904ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. thymidine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    KinaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    DNA synthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciVCHO1134456:GLMN-1150-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
    Gene namesi
    Name:tdkUniRule annotation
    ORF Names:O3Y_05445Imported
    OrganismiVibrio cholerae IEC224Imported
    Taxonomic identifieri1134456 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000010113: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotationSAAS annotation

    Structurei

    3D structure databases

    ProteinModelPortaliH8JW16.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thymidine kinase family.UniRule annotation

    Phylogenomic databases

    KOiK00857.

    Family and domain databases

    HAMAPiMF_00124. Thymidine_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view]
    PANTHERiPTHR11441. PTHR11441. 1 hit.
    PfamiPF00265. TK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF035805. TK_cell. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H8JW16-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQMYFYYSA MNAGKSTTLL QSAFNYQERG MNPLIFTAAI DDRFGVGKVS    50
    SRIGLEAEAH LFHADTDLLH VIATLHEAEP RHCILMDECQ FLSKEQVYQL 100
    TEVVDKLDIP VLCYGLRTDF LGELFEGSKY LLSWADKLIE LKTICHCGRK 150
    ANMVIRTDEH GNAISEGDQV AIGGNDKYVS VCRQHYKEAL GR 192
    Length:192
    Mass (Da):21,659
    Last modified:May 16, 2012 - v1
    Checksum:iB2532D1C6CBA9E8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003330 Genomic DNA. Translation: AFC57969.1.
    RefSeqiYP_005332957.1. NC_016944.1.

    Genome annotation databases

    EnsemblBacteriaiAFC57969; AFC57969; O3Y_05445.
    GeneIDi11914085.
    KEGGivci:O3Y_05445.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003330 Genomic DNA. Translation: AFC57969.1 .
    RefSeqi YP_005332957.1. NC_016944.1.

    3D structure databases

    ProteinModelPortali H8JW16.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFC57969 ; AFC57969 ; O3Y_05445 .
    GeneIDi 11914085.
    KEGGi vci:O3Y_05445.

    Phylogenomic databases

    KOi K00857.

    Enzyme and pathway databases

    BioCyci VCHO1134456:GLMN-1150-MONOMER.

    Family and domain databases

    HAMAPi MF_00124. Thymidine_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR001267. Thymidine_kinase.
    IPR020633. Thymidine_kinase_CS.
    IPR020634. Thymidine_kinase_subgr.
    [Graphical view ]
    PANTHERi PTHR11441. PTHR11441. 1 hit.
    Pfami PF00265. TK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF035805. TK_cell. 1 hit.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete Genome Sequence of a Sucrose-Nonfermenting Epidemic Strain of Vibrio cholerae O1 from Brazil."
      Morais L.L., Garza D.R., Loureiro E.C., Nunes K.N., Vellasco R.S., da Silva C.P., Nunes M.R., Thompson C.C., Vicente A.C., Santos E.C.
      J. Bacteriol. 194:2772-2772(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IEC224Imported.
    2. "Genome-Wide Study of the Defective Sucrose Fermenter Strain of Vibrio cholerae from the Latin American Cholera Epidemic."
      Garza D.R., Thompson C.C., Loureiro E.C., Dutilh B.E., Inada D.T., Junior E.C., Cardoso J.F., Nunes M.R., de Lima C.P., Silvestre R.V., Nunes K.N., Santos E.C., Edwards R.A., Vicente A.C., de Sa Morais L.L.
      PLoS ONE 7:E37283-E37283(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IEC224Imported.

    Entry informationi

    Entry nameiH8JW16_VIBCL
    AccessioniPrimary (citable) accession number: H8JW16
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 16, 2012
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3