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H8JW16

- H8JW16_VIBCL

UniProt

H8JW16 - H8JW16_VIBCL

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Protein

Thymidine kinase

Gene
tdk, O3Y_05445
Organism
Vibrio cholerae IEC224
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei88 – 881Proton acceptor By similarityUniRule annotation
Metal bindingi145 – 1451Zinc By similarityUniRule annotation
Metal bindingi147 – 1471Zinc By similarityUniRule annotation
Metal bindingi182 – 1821Zinc By similarityUniRule annotation
Metal bindingi185 – 1851Zinc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATP By similarityUniRule annotation
Nucleotide bindingi87 – 904ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotationSAAS annotations, Nucleotide-binding, ZincUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciVCHO1134456:GLMN-1150-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
ORF Names:O3Y_05445Imported
OrganismiVibrio cholerae IEC224Imported
Taxonomic identifieri1134456 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000010113: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotationSAAS annotations

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotations

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotationSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliH8JW16.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00857.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8JW16-1 [UniParc]FASTAAdd to Basket

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MAQMYFYYSA MNAGKSTTLL QSAFNYQERG MNPLIFTAAI DDRFGVGKVS    50
SRIGLEAEAH LFHADTDLLH VIATLHEAEP RHCILMDECQ FLSKEQVYQL 100
TEVVDKLDIP VLCYGLRTDF LGELFEGSKY LLSWADKLIE LKTICHCGRK 150
ANMVIRTDEH GNAISEGDQV AIGGNDKYVS VCRQHYKEAL GR 192
Length:192
Mass (Da):21,659
Last modified:May 16, 2012 - v1
Checksum:iB2532D1C6CBA9E8F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003330 Genomic DNA. Translation: AFC57969.1.
RefSeqiYP_005332957.1. NC_016944.1.

Genome annotation databases

EnsemblBacteriaiAFC57969; AFC57969; O3Y_05445.
GeneIDi11914085.
KEGGivci:O3Y_05445.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003330 Genomic DNA. Translation: AFC57969.1 .
RefSeqi YP_005332957.1. NC_016944.1.

3D structure databases

ProteinModelPortali H8JW16.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFC57969 ; AFC57969 ; O3Y_05445 .
GeneIDi 11914085.
KEGGi vci:O3Y_05445.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci VCHO1134456:GLMN-1150-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of a Sucrose-Nonfermenting Epidemic Strain of Vibrio cholerae O1 from Brazil."
    Morais L.L., Garza D.R., Loureiro E.C., Nunes K.N., Vellasco R.S., da Silva C.P., Nunes M.R., Thompson C.C., Vicente A.C., Santos E.C.
    J. Bacteriol. 194:2772-2772(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IEC224Imported.
  2. "Genome-Wide Study of the Defective Sucrose Fermenter Strain of Vibrio cholerae from the Latin American Cholera Epidemic."
    Garza D.R., Thompson C.C., Loureiro E.C., Dutilh B.E., Inada D.T., Junior E.C., Cardoso J.F., Nunes M.R., de Lima C.P., Silvestre R.V., Nunes K.N., Santos E.C., Edwards R.A., Vicente A.C., de Sa Morais L.L.
    PLoS ONE 7:E37283-E37283(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IEC224Imported.

Entry informationi

Entry nameiH8JW16_VIBCL
AccessioniPrimary (citable) accession number: H8JW16
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: September 3, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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