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H8JVB4 (H8JVB4_VIBCL) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alanine racemase HAMAP-Rule MF_01201

EC=5.1.1.1 HAMAP-Rule MF_01201
Gene names
Name:alr EMBL AFC57232.1
ORF Names:O3Y_01725 EMBL AFC57232.1
OrganismVibrio cholerae IEC224 [Complete proteome] EMBL AFC57232.1
Taxonomic identifier1134456 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. SAAS SAAS009006 HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. SAAS SAAS009006 HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family. RuleBase RU004188 HAMAP-Rule MF_01201

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site341Proton acceptor; specific for D-alanine By similarity HAMAP-Rule MF_01201
Active site2541Proton acceptor; specific for L-alanine By similarity HAMAP-Rule MF_01201
Binding site1291Substrate By similarity HAMAP-Rule MF_01201
Binding site3021Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01201

Amino acid modifications

Modified residue341N6-(pyridoxal phosphate)lysine By similarity HAMAP-Rule MF_01201

Sequences

Sequence LengthMass (Da)Tools
H8JVB4 [UniParc].

Last modified May 16, 2012. Version 1.
Checksum: EBD185735204A735

FASTA36139,349
        10         20         30         40         50         60 
MKAATAYINL EALQHNLQRV KQQAPESKIM AVVKANGYGH GLRHIARHAL GADAFGVARI 

        70         80         90        100        110        120 
EEALQLRASG VVKPILLLEG FYSPGDLPVL VTNNIQTVVH CEEQLQALEQ AQLETPVMVW 

       130        140        150        160        170        180 
LKVDSGMHRL GVRPEQYQDF VARLHQCENV AKPLRYMSHF GCADELDKST TVEQTELFLS 

       190        200        210        220        230        240 
LTQGCQGERS LAASAGLLAW PQSQLEWVRP GIIMYGVSPF VEKSAVQLGY QPVMTLKSHL 

       250        260        270        280        290        300 
IAVREVKAGE SVGYGGTWTS QRDTKIGVIA IGYGDGYPRT APNGTPVVVN GRRVPIAGRV 

       310        320        330        340        350        360 
SMDMLTVDLG PDACDRVGDE AMLWGNELPV EEVAAHIGTI GYELVTKLTS RVEMSYYGAG 


V 

« Hide

References

[1]"Complete Genome Sequence of a Sucrose-Nonfermenting Epidemic Strain of Vibrio cholerae O1 from Brazil."
Morais L.L., Garza D.R., Loureiro E.C., Nunes K.N., Vellasco R.S., da Silva C.P., Nunes M.R., Thompson C.C., Vicente A.C., Santos E.C.
J. Bacteriol. 194:2772-2772(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: IEC224 EMBL AFC57232.1.
[2]"Genome-Wide Study of the Defective Sucrose Fermenter Strain of Vibrio cholerae from the Latin American Cholera Epidemic."
Garza D.R., Thompson C.C., Loureiro E.C., Dutilh B.E., Inada D.T., Junior E.C., Cardoso J.F., Nunes M.R., de Lima C.P., Silvestre R.V., Nunes K.N., Santos E.C., Edwards R.A., Vicente A.C., de Sa Morais L.L.
PLoS ONE 7:E37283-E37283(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: IEC224 EMBL AFC57232.1.
[3]Garza D.R.Jr., Thompson C.C., Loureiro E.C.B., Dutilh B.E., Inada D.T., Junior E.C.S., Cardoso J.F., Nunes M.R.T., de Lima C.P.S., Vellasco R.S., Nunes K.N.B., Santos E.C.O., Edwards R.A., Vicente A.C.P., Morais L.L.C.S.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: IEC224 EMBL AFC57232.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003330 Genomic DNA. Translation: AFC57232.1.
RefSeqYP_005332220.1. NC_016944.1.

3D structure databases

ProteinModelPortalH8JVB4.
SMRH8JVB4. Positions 3-356.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFC57232; AFC57232; O3Y_01725.
GeneID11913312.
KEGGvci:O3Y_01725.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01775.

Enzyme and pathway databases

BioCycVCHO1134456:GLMN-377-MONOMER.
UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH8JVB4_VIBCL
AccessionPrimary (citable) accession number: H8JVB4
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: February 19, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)