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H8J9J5

- H8J9J5_MYCIT

UniProt

H8J9J5 - H8J9J5_MYCIT

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Protein

Probable DNA ligase

Gene
lig, OCO_37620
Organism
Mycobacterium intracellulare MOTT-02
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei211 – 2111ATP By similarityUniRule annotation
Active sitei213 – 2131N6-AMP-lysine intermediate By similarityUniRule annotation
Binding sitei218 – 2181ATP By similarityUniRule annotation
Binding sitei233 – 2331ATP By similarityUniRule annotation
Binding sitei262 – 2621ATP By similarityUniRule annotation
Binding sitei302 – 3021ATP By similarityUniRule annotation
Binding sitei374 – 3741ATP By similarityUniRule annotation
Binding sitei380 – 3801ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Biological processi

Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMINT1138382:GLGO-3803-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP]
Gene namesi
Name:ligUniRule annotation
ORF Names:OCO_37620Imported
OrganismiMycobacterium intracellulare MOTT-02Imported
Taxonomic identifieri1138382 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000008002: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK01971.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8J9J5-1 [UniParc]FASTAAdd to Basket

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MLLLDVAKAS TDVGSTSSRL RKVAHIADLL ARAAPDPALV MIVVSWLSGE    50
LRQRQIGVGW AALRSRPPPA SHATLTVGAV DATFSEIGAV SGKGAQARRA 100
ALLTTLFAAA TEAEQTFLLR LLGGELRQGA LAGIMADAVA KAAGIPAAAV 150
QRAAMLGGDL PAVAAAALSG EPAALQAFTL RVGRPVGPML AQTAPSVADA 200
IERHGGRAIF EAKLDGARVQ IHRSGDQVTV YTRSLDDVTA RVPEVVEATL 250
ALPVNDLIAD GEAIALRPDN RPQRFQVTAS RFGRSVDVAA AVAAQPLSVF 300
FFDILHRDGV DLLDAPTTDR LAALDALVPP AQRVDRLLTS DPVEAGAFLD 350
ATLAAGHEGV MAKAPDAQYQ AGRRGAGWLK VKPVHTLDLV VLAVEWGSGR 400
RRGKLSNIHL GARDPDSGEF VMVGKTFKGM TDAMLDWQTA RFTDLAIGGT 450
DGYVVHVRPE QVVEVALDGV QKSSRYPGGL ALRFARVVRY RDDKGPAEAD 500
TIDAVRALY 509
Length:509
Mass (Da):53,535
Last modified:May 16, 2012 - v1
Checksum:iE36C9F8B2829A4DA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003323 Genomic DNA. Translation: AFC50125.1.
RefSeqiYP_005344446.1. NC_016947.1.

Genome annotation databases

EnsemblBacteriaiAFC50125; AFC50125; OCO_37620.
GeneIDi11905314.
KEGGimit:OCO_37620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003323 Genomic DNA. Translation: AFC50125.1 .
RefSeqi YP_005344446.1. NC_016947.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFC50125 ; AFC50125 ; OCO_37620 .
GeneIDi 11905314.
KEGGi mit:OCO_37620.

Phylogenomic databases

KOi K01971.

Enzyme and pathway databases

BioCyci MINT1138382:GLGO-3803-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of Mycobacterium intracellulare Clinical Strain MOTT-02."
    Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J., Kook Y.H., Kim B.J.
    J. Bacteriol. 194:2771-2771(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MOTT-02Imported.

Entry informationi

Entry nameiH8J9J5_MYCIT
AccessioniPrimary (citable) accession number: H8J9J5
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: September 3, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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