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H8J9J5 (H8J9J5_MYCIT) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Probable DNA ligase HAMAP-Rule MF_00407

EC=6.5.1.1 HAMAP-Rule MF_00407
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] HAMAP-Rule MF_00407
Gene names
Name:lig HAMAP-Rule MF_00407
ORF Names:OCO_37620 EMBL AFC50125.1
OrganismMycobacterium intracellulare MOTT-02 [Complete proteome] EMBL AFC50125.1
Taxonomic identifier1138382 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity. HAMAP-Rule MF_00407

Catalytic activity

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m). HAMAP-Rule MF_00407

Cofactor

Divalent metal cations By similarity. HAMAP-Rule MF_00407

Sequence similarities

Belongs to the ATP-dependent DNA ligase family. HAMAP-Rule MF_00407 RuleBase RU004196

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site2131N6-AMP-lysine intermediate By similarity HAMAP-Rule MF_00407
Binding site2111ATP By similarity HAMAP-Rule MF_00407
Binding site2181ATP By similarity HAMAP-Rule MF_00407
Binding site2331ATP By similarity HAMAP-Rule MF_00407
Binding site2621ATP By similarity HAMAP-Rule MF_00407
Binding site3021ATP By similarity HAMAP-Rule MF_00407
Binding site3741ATP By similarity HAMAP-Rule MF_00407
Binding site3801ATP By similarity HAMAP-Rule MF_00407

Sequences

Sequence LengthMass (Da)Tools
H8J9J5 [UniParc].

Last modified May 16, 2012. Version 1.
Checksum: E36C9F8B2829A4DA

FASTA50953,535
        10         20         30         40         50         60 
MLLLDVAKAS TDVGSTSSRL RKVAHIADLL ARAAPDPALV MIVVSWLSGE LRQRQIGVGW 

        70         80         90        100        110        120 
AALRSRPPPA SHATLTVGAV DATFSEIGAV SGKGAQARRA ALLTTLFAAA TEAEQTFLLR 

       130        140        150        160        170        180 
LLGGELRQGA LAGIMADAVA KAAGIPAAAV QRAAMLGGDL PAVAAAALSG EPAALQAFTL 

       190        200        210        220        230        240 
RVGRPVGPML AQTAPSVADA IERHGGRAIF EAKLDGARVQ IHRSGDQVTV YTRSLDDVTA 

       250        260        270        280        290        300 
RVPEVVEATL ALPVNDLIAD GEAIALRPDN RPQRFQVTAS RFGRSVDVAA AVAAQPLSVF 

       310        320        330        340        350        360 
FFDILHRDGV DLLDAPTTDR LAALDALVPP AQRVDRLLTS DPVEAGAFLD ATLAAGHEGV 

       370        380        390        400        410        420 
MAKAPDAQYQ AGRRGAGWLK VKPVHTLDLV VLAVEWGSGR RRGKLSNIHL GARDPDSGEF 

       430        440        450        460        470        480 
VMVGKTFKGM TDAMLDWQTA RFTDLAIGGT DGYVVHVRPE QVVEVALDGV QKSSRYPGGL 

       490        500 
ALRFARVVRY RDDKGPAEAD TIDAVRALY 

« Hide

References

[1]"Complete Genome Sequence of Mycobacterium intracellulare Clinical Strain MOTT-02."
Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J., Kook Y.H., Kim B.J.
J. Bacteriol. 194:2771-2771(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MOTT-02 EMBL AFC50125.1.
[2]Kim B.-J., Lee J.H., Lim J.-S., Choi I.-Y., Choi B.-S., Lim J.-S.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MOTT-02 EMBL AFC50125.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003323 Genomic DNA. Translation: AFC50125.1.
RefSeqYP_005344446.1. NC_016947.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFC50125; AFC50125; OCO_37620.
GeneID11905314.
KEGGmit:OCO_37620.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01971.

Enzyme and pathway databases

BioCycMINT1138382:GLGO-3803-MONOMER.

Family and domain databases

Gene3D1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPMF_00407. DNA_ligase.
InterProIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsTIGR00574. dnl1. 1 hit.
PROSITEPS00697. DNA_LIGASE_A1. 1 hit.
PS00333. DNA_LIGASE_A2. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH8J9J5_MYCIT
AccessionPrimary (citable) accession number: H8J9J5
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: February 19, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)