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H8J9J5

- H8J9J5_MYCIT

UniProt

H8J9J5 - H8J9J5_MYCIT

Protein

Probable DNA ligase

Gene

lig

Organism
Mycobacterium intracellulare MOTT-02
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (16 May 2012)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei211 – 2111ATPUniRule annotation
    Active sitei213 – 2131N6-AMP-lysine intermediateUniRule annotation
    Binding sitei218 – 2181ATPUniRule annotation
    Binding sitei233 – 2331ATPUniRule annotation
    Binding sitei262 – 2621ATPUniRule annotation
    Binding sitei302 – 3021ATPUniRule annotation
    Binding sitei374 – 3741ATPUniRule annotation
    Binding sitei380 – 3801ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMINT1138382:GLGO-3803-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligUniRule annotation
    ORF Names:OCO_37620Imported
    OrganismiMycobacterium intracellulare MOTT-02Imported
    Taxonomic identifieri1138382 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
    ProteomesiUP000008002: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Phylogenomic databases

    KOiK01971.

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H8J9J5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLLDVAKAS TDVGSTSSRL RKVAHIADLL ARAAPDPALV MIVVSWLSGE    50
    LRQRQIGVGW AALRSRPPPA SHATLTVGAV DATFSEIGAV SGKGAQARRA 100
    ALLTTLFAAA TEAEQTFLLR LLGGELRQGA LAGIMADAVA KAAGIPAAAV 150
    QRAAMLGGDL PAVAAAALSG EPAALQAFTL RVGRPVGPML AQTAPSVADA 200
    IERHGGRAIF EAKLDGARVQ IHRSGDQVTV YTRSLDDVTA RVPEVVEATL 250
    ALPVNDLIAD GEAIALRPDN RPQRFQVTAS RFGRSVDVAA AVAAQPLSVF 300
    FFDILHRDGV DLLDAPTTDR LAALDALVPP AQRVDRLLTS DPVEAGAFLD 350
    ATLAAGHEGV MAKAPDAQYQ AGRRGAGWLK VKPVHTLDLV VLAVEWGSGR 400
    RRGKLSNIHL GARDPDSGEF VMVGKTFKGM TDAMLDWQTA RFTDLAIGGT 450
    DGYVVHVRPE QVVEVALDGV QKSSRYPGGL ALRFARVVRY RDDKGPAEAD 500
    TIDAVRALY 509
    Length:509
    Mass (Da):53,535
    Last modified:May 16, 2012 - v1
    Checksum:iE36C9F8B2829A4DA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003323 Genomic DNA. Translation: AFC50125.1.
    RefSeqiYP_005344446.1. NC_016947.1.

    Genome annotation databases

    EnsemblBacteriaiAFC50125; AFC50125; OCO_37620.
    GeneIDi11905314.
    KEGGimit:OCO_37620.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003323 Genomic DNA. Translation: AFC50125.1 .
    RefSeqi YP_005344446.1. NC_016947.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFC50125 ; AFC50125 ; OCO_37620 .
    GeneIDi 11905314.
    KEGGi mit:OCO_37620.

    Phylogenomic databases

    KOi K01971.

    Enzyme and pathway databases

    BioCyci MINT1138382:GLGO-3803-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS00333. DNA_LIGASE_A2. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete Genome Sequence of Mycobacterium intracellulare Clinical Strain MOTT-02."
      Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J., Kook Y.H., Kim B.J.
      J. Bacteriol. 194:2771-2771(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MOTT-02Imported.

    Entry informationi

    Entry nameiH8J9J5_MYCIT
    AccessioniPrimary (citable) accession number: H8J9J5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 16, 2012
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3