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H8J8J9 (H8J8J9_MYCIT) Unreviewed, UniProtKB/TrEMBL

Last modified April 3, 2013. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-isopropylmalate dehydratase small subunit HAMAP-Rule MF_01031
EC=4.2.1.33 HAMAP-Rule MF_01031
Alternative name(s):
Alpha-IPM isomerase HAMAP-Rule MF_01031
Isopropylmalate isomerase HAMAP-Rule MF_01031
Gene names
Name:leuD HAMAP-Rule MF_01031
ORF Names:OCO_36570 EMBL AFC50020.1
OrganismMycobacterium intracellulare MOTT-02 EMBL AFC50020.1
Taxonomic identifier1138382 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC) ›

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate By similarity. SAAS SAAS004431 HAMAP-Rule MF_01031

Catalytic activity

(2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. SAAS SAAS004431 HAMAP-Rule MF_01031

Pathway

Amino-acid biosynthesis; L-leucine biosynthesis; L-leucine from 3-methyl-2-oxobutanoate: step 2/4. SAAS SAAS004431 HAMAP-Rule MF_01031

Subunit structure

Heterodimer of LeuC and LeuD By similarity. HAMAP-Rule MF_01031

Sequence similarities

Belongs to the LeuD family. LeuD type 1 subfamily. HAMAP-Rule MF_01031

Sequences

Sequence LengthMass (Da)Tools
H8J8J9 [UniParc].

Last modified May 16, 2012. Version 1.
Checksum: 04DC6F7BF0FDB2B3

FASTA19821,895
        10         20         30         40         50         60 
MEAFHTHTGI GVPLRRSNVD TDQIIPAVYL KRVTRTGFED GLFASWRSDP SFVLNLSPFD 

        70         80         90        100        110        120 
RGSVLVAGPD FGTGSSREHA VWALMDYGFR VVISSRFGDI FRGNAGKAGL LAAEVSQDGV 

       130        140        150        160        170        180 
ELLWKLIEQS PGLEITANLQ DRNITAGTTV LPFKIDDHTA WRLLEGLDDI ALTLRKLDEI 

       190 
ESFEAAYPDW KPRTLSTS

« Hide

References

[1]"Complete Genome Sequence of Mycobacterium intracellulare Clinical Strain MOTT-02."
Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J., Kook Y.H., Kim B.J.
J. Bacteriol. 194:2771-2771(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MOTT-02 EMBL AFC50020.1.
[2]Kim B.-J., Lee J.H., Lim J.-S., Choi I.-Y., Choi B.-S., Lim J.-S.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MOTT-02 EMBL AFC50020.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003323 Genomic DNA. Translation: AFC50020.1.
RefSeqYP_005344341.1. NC_016947.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFC50020; AFC50020; OCO_36570.
GeneID11905205.
KEGGmit:OCO_36570.

Phylogenomic databases

KOK01704.

Enzyme and pathway databases

UniPathwayUPA00048; UER00071.

Family and domain databases

Gene3D3.20.19.10. 1 hit.
HAMAPMF_01031. LeuD_type1.
InterProIPR004431. 3-IsopropMal_deHydase_ssu.
IPR015937. Acoase/IPM_deHydtase.
IPR015928. Aconitase/3IPM_dehydase_swvl.
IPR000573. AconitaseA/IPMdHydase_ssu_swvl.
[Graphical view]
PANTHERPTHR11670. PTHR11670. 1 hit.
PTHR11670:SF2. PTHR11670:SF2. 1 hit.
PfamPF00694. Aconitase_C. 1 hit.
[Graphical view]
SUPFAMSSF52016. Aconitase/3IPM_dehydase_swvl. 1 hit.
TIGRFAMsTIGR00171. leuD. 1 hit.
ProtoNetSearch...

Entry information

Entry nameH8J8J9_MYCIT
AccessionPrimary (citable) accession number: H8J8J9
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: April 3, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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