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H8IZR4

- H8IZR4_MYCIT

UniProt

H8IZR4 - H8IZR4_MYCIT

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Protein

Isocitrate dehydrogenase [NADP]

Gene

OCO_41790

Organism
Mycobacterium intracellulare MOTT-02
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841SubstrateUniRule annotation
Binding sitei116 – 1161SubstrateUniRule annotation
Binding sitei139 – 1391SubstrateUniRule annotation
Sitei146 – 1461Critical for catalysisUniRule annotation
Sitei219 – 2191Critical for catalysisUniRule annotation
Metal bindingi259 – 2591Magnesium or manganeseUniRule annotation
Metal bindingi282 – 2821Magnesium or manganeseUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciMINT1138382:GLGO-4222-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:OCO_41790Imported
OrganismiMycobacterium intracellulare MOTT-02Imported
Taxonomic identifieri1138382 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000008002: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni101 – 1077Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8IZR4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSPGSKEAK IKVKGRVVEL DGDEMTRVIW KLIKDQLILP HLDIDLDYYD
60 70 80 90 100
LGIEHRDRTD DQVTIDAAYA IKKHGVGVKC ATITPDEARV SEFNLKKMWL
110 120 130 140 150
SPNGTIRNIL GGTIFREPIV ISNVPRLVPG WTKPIVIGRH AFGDQYRATN
160 170 180 190 200
FKVDKPGTVA ITFTPADGSE PMVHEMVSLP DDGGVVMGMY NFKDSVRDFA
210 220 230 240 250
RASFKYGLNA KWPVYLSTKN TILKAYDGMF KDEFQRIYDE EFKEQFEAEG
260 270 280 290 300
LTYEHRLIDD MVAACLKWEG GYVWACKNYD GDVQSDAIAQ GYGSLGLMTS
310 320 330 340 350
VLMTADGKTV EAEAAHGTVT RHFRQYQAGK PTSTNPIASI FAWTRGLAHR
360 370 380 390 400
GKLDDTPEVV EFAQTLENVV VSTVDSGKMT KDLAILIGPD QEWQQSEEFL
410
DSIAENLEKE LAS
Length:413
Mass (Da):46,119
Last modified:May 16, 2012 - v1
Checksum:iDF4FD421A442F3B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003323 Genomic DNA. Translation: AFC50542.1.
RefSeqiYP_005344863.1. NC_016947.1.

Genome annotation databases

EnsemblBacteriaiAFC50542; AFC50542; OCO_41790.
GeneIDi11905735.
KEGGimit:OCO_41790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003323 Genomic DNA. Translation: AFC50542.1 .
RefSeqi YP_005344863.1. NC_016947.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFC50542 ; AFC50542 ; OCO_41790 .
GeneIDi 11905735.
KEGGi mit:OCO_41790.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci MINT1138382:GLGO-4222-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of Mycobacterium intracellulare Clinical Strain MOTT-02."
    Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J., Kook Y.H., Kim B.J.
    J. Bacteriol. 194:2771-2771(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MOTT-02Imported.

Entry informationi

Entry nameiH8IZR4_MYCIT
AccessioniPrimary (citable) accession number: H8IZR4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: November 26, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3