Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Isocitrate dehydrogenase [NADP]

Gene

OCO_41790

Organism
Mycobacterium intracellulare MOTT-02
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotationNote: Binds 1 Mg(2+) or Mn2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841SubstrateUniRule annotation
Binding sitei89 – 891NADPUniRule annotation
Binding sitei116 – 1161SubstrateUniRule annotation
Binding sitei139 – 1391SubstrateUniRule annotation
Sitei146 – 1461Critical for catalysisUniRule annotation
Sitei219 – 2191Critical for catalysisUniRule annotation
Metal bindingi259 – 2591Magnesium or manganeseUniRule annotation
Binding sitei267 – 2671NADPUniRule annotation
Metal bindingi282 – 2821Magnesium or manganeseUniRule annotation
Binding sitei335 – 3351NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi82 – 843NADPUniRule annotation
Nucleotide bindingi317 – 3226NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciMINT1138382:GLGO-4222-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:OCO_41790Imported
OrganismiMycobacterium intracellulare MOTT-02Imported
Taxonomic identifieri1138382 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000008002: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni101 – 1077Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8IZR4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSPGSKEAK IKVKGRVVEL DGDEMTRVIW KLIKDQLILP HLDIDLDYYD
60 70 80 90 100
LGIEHRDRTD DQVTIDAAYA IKKHGVGVKC ATITPDEARV SEFNLKKMWL
110 120 130 140 150
SPNGTIRNIL GGTIFREPIV ISNVPRLVPG WTKPIVIGRH AFGDQYRATN
160 170 180 190 200
FKVDKPGTVA ITFTPADGSE PMVHEMVSLP DDGGVVMGMY NFKDSVRDFA
210 220 230 240 250
RASFKYGLNA KWPVYLSTKN TILKAYDGMF KDEFQRIYDE EFKEQFEAEG
260 270 280 290 300
LTYEHRLIDD MVAACLKWEG GYVWACKNYD GDVQSDAIAQ GYGSLGLMTS
310 320 330 340 350
VLMTADGKTV EAEAAHGTVT RHFRQYQAGK PTSTNPIASI FAWTRGLAHR
360 370 380 390 400
GKLDDTPEVV EFAQTLENVV VSTVDSGKMT KDLAILIGPD QEWQQSEEFL
410
DSIAENLEKE LAS
Length:413
Mass (Da):46,119
Last modified:May 16, 2012 - v1
Checksum:iDF4FD421A442F3B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003323 Genomic DNA. Translation: AFC50542.1.
RefSeqiYP_005344863.1. NC_016947.1.

Genome annotation databases

EnsemblBacteriaiAFC50542; AFC50542; OCO_41790.
GeneIDi11905735.
KEGGimit:OCO_41790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003323 Genomic DNA. Translation: AFC50542.1.
RefSeqiYP_005344863.1. NC_016947.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFC50542; AFC50542; OCO_41790.
GeneIDi11905735.
KEGGimit:OCO_41790.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciMINT1138382:GLGO-4222-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete Genome Sequence of Mycobacterium intracellulare Clinical Strain MOTT-02."
    Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J., Kook Y.H., Kim B.J.
    J. Bacteriol. 194:2771-2771(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MOTT-02Imported.

Entry informationi

Entry nameiH8IZR4_MYCIT
AccessioniPrimary (citable) accession number: H8IZR4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: February 4, 2015
This is version 19 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.