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H8IZR4

- H8IZR4_MYCIT

UniProt

H8IZR4 - H8IZR4_MYCIT

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Protein
Isocitrate dehydrogenase [NADP]
Gene
OCO_41790
Organism
Mycobacterium intracellulare MOTT-02
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei84 – 841Substrate By similarity
Binding sitei89 – 891NADP By similarityUniRule annotation
Binding sitei116 – 1161Substrate By similarityUniRule annotation
Binding sitei139 – 1391Substrate By similarity
Sitei146 – 1461Critical for catalysis By similarityUniRule annotation
Sitei219 – 2191Critical for catalysis By similarityUniRule annotation
Metal bindingi259 – 2591Magnesium or manganese By similarityUniRule annotation
Binding sitei267 – 2671NADP By similarityUniRule annotation
Metal bindingi282 – 2821Magnesium or manganese By similarityUniRule annotation
Binding sitei335 – 3351NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi82 – 843NADP By similarityUniRule annotation
Nucleotide bindingi317 – 3226NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciMINT1138382:GLGO-4222-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:OCO_41790Imported
OrganismiMycobacterium intracellulare MOTT-02Imported
Taxonomic identifieri1138382 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000008002: Chromosome

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni101 – 1077Substrate binding By similarity

Sequence similaritiesi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8IZR4-1 [UniParc]FASTAAdd to Basket

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MSSPGSKEAK IKVKGRVVEL DGDEMTRVIW KLIKDQLILP HLDIDLDYYD    50
LGIEHRDRTD DQVTIDAAYA IKKHGVGVKC ATITPDEARV SEFNLKKMWL 100
SPNGTIRNIL GGTIFREPIV ISNVPRLVPG WTKPIVIGRH AFGDQYRATN 150
FKVDKPGTVA ITFTPADGSE PMVHEMVSLP DDGGVVMGMY NFKDSVRDFA 200
RASFKYGLNA KWPVYLSTKN TILKAYDGMF KDEFQRIYDE EFKEQFEAEG 250
LTYEHRLIDD MVAACLKWEG GYVWACKNYD GDVQSDAIAQ GYGSLGLMTS 300
VLMTADGKTV EAEAAHGTVT RHFRQYQAGK PTSTNPIASI FAWTRGLAHR 350
GKLDDTPEVV EFAQTLENVV VSTVDSGKMT KDLAILIGPD QEWQQSEEFL 400
DSIAENLEKE LAS 413
Length:413
Mass (Da):46,119
Last modified:May 16, 2012 - v1
Checksum:iDF4FD421A442F3B9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003323 Genomic DNA. Translation: AFC50542.1.
RefSeqiYP_005344863.1. NC_016947.1.

Genome annotation databases

EnsemblBacteriaiAFC50542; AFC50542; OCO_41790.
GeneIDi11905735.
KEGGimit:OCO_41790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003323 Genomic DNA. Translation: AFC50542.1 .
RefSeqi YP_005344863.1. NC_016947.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFC50542 ; AFC50542 ; OCO_41790 .
GeneIDi 11905735.
KEGGi mit:OCO_41790.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci MINT1138382:GLGO-4222-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete Genome Sequence of Mycobacterium intracellulare Clinical Strain MOTT-02."
    Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J., Kook Y.H., Kim B.J.
    J. Bacteriol. 194:2771-2771(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MOTT-02Imported.

Entry informationi

Entry nameiH8IZR4_MYCIT
AccessioniPrimary (citable) accession number: H8IZR4
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: September 3, 2014
This is version 14 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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