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H8IZR4 (H8IZR4_MYCIT) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 9. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108
EC=1.1.1.42 PIRNR PIRNR000108
Gene names
ORF Names:OCO_41790 EMBL AFC50542.1
OrganismMycobacterium intracellulare MOTT-02 EMBL AFC50542.1
Taxonomic identifier1138382 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium avium complex (MAC) ›

Protein attributes

Sequence length413 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443 PIRNR PIRNR000108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding82 – 843NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding317 – 3226NADP By similarity PIRSR PIRSR000108-4
Region101 – 1077Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2591Magnesium or manganese By similarity PIRSR PIRSR000108-3
Metal binding2821Magnesium or manganese By similarity PIRSR PIRSR000108-3
Binding site841Substrate By similarity PIRSR PIRSR000108-2
Binding site891NADP By similarity PIRSR PIRSR000108-4
Binding site1161Substrate By similarity PIRSR PIRSR000108-2
Binding site1391Substrate By similarity PIRSR PIRSR000108-2
Binding site2671NADP By similarity PIRSR PIRSR000108-4
Binding site3351NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1461Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2191Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
H8IZR4 [UniParc].

Last modified May 16, 2012. Version 1.
Checksum: DF4FD421A442F3B9

FASTA41346,119
        10         20         30         40         50         60 
MSSPGSKEAK IKVKGRVVEL DGDEMTRVIW KLIKDQLILP HLDIDLDYYD LGIEHRDRTD 

        70         80         90        100        110        120 
DQVTIDAAYA IKKHGVGVKC ATITPDEARV SEFNLKKMWL SPNGTIRNIL GGTIFREPIV 

       130        140        150        160        170        180 
ISNVPRLVPG WTKPIVIGRH AFGDQYRATN FKVDKPGTVA ITFTPADGSE PMVHEMVSLP 

       190        200        210        220        230        240 
DDGGVVMGMY NFKDSVRDFA RASFKYGLNA KWPVYLSTKN TILKAYDGMF KDEFQRIYDE 

       250        260        270        280        290        300 
EFKEQFEAEG LTYEHRLIDD MVAACLKWEG GYVWACKNYD GDVQSDAIAQ GYGSLGLMTS 

       310        320        330        340        350        360 
VLMTADGKTV EAEAAHGTVT RHFRQYQAGK PTSTNPIASI FAWTRGLAHR GKLDDTPEVV 

       370        380        390        400        410 
EFAQTLENVV VSTVDSGKMT KDLAILIGPD QEWQQSEEFL DSIAENLEKE LAS

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References

[1]"Complete Genome Sequence of Mycobacterium intracellulare Clinical Strain MOTT-02."
Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J., Kook Y.H., Kim B.J.
J. Bacteriol. 194:2771-2771(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MOTT-02 EMBL AFC50542.1.
[2]Kim B.-J., Lee J.H., Lim J.-S., Choi I.-Y., Choi B.-S., Lim J.-S.
Submitted (FEB-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MOTT-02 EMBL AFC50542.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003323 Genomic DNA. Translation: AFC50542.1.
RefSeqYP_005344863.1. NC_016947.1.

3D structure databases

ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFC50542; AFC50542; OCO_41790.
GeneID11905735.
KEGGmit:OCO_41790.

Phylogenomic databases

KOK00031.

Enzyme and pathway databases

BioCycMINT1138382:GLGO-4222-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH8IZR4_MYCIT
AccessionPrimary (citable) accession number: H8IZR4
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: May 29, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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