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H8IZR4

- H8IZR4_MYCIT

UniProt

H8IZR4 - H8IZR4_MYCIT

Protein

Isocitrate dehydrogenase [NADP]

Gene

OCO_41790

Organism
Mycobacterium intracellulare MOTT-02
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 15 (01 Oct 2014)
      Sequence version 1 (16 May 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei84 – 841SubstrateUniRule annotation
    Binding sitei89 – 891NADP
    Binding sitei116 – 1161SubstrateUniRule annotation
    Binding sitei139 – 1391SubstrateUniRule annotation
    Sitei146 – 1461Critical for catalysisUniRule annotation
    Sitei219 – 2191Critical for catalysisUniRule annotation
    Metal bindingi259 – 2591Magnesium or manganeseUniRule annotation
    Binding sitei267 – 2671NADP
    Metal bindingi282 – 2821Magnesium or manganeseUniRule annotation
    Binding sitei335 – 3351NADP; via amide nitrogen and carbonyl oxygen

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi82 – 843NADP
    Nucleotide bindingi317 – 3226NADP

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. isocitrate metabolic process Source: InterPro
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationImported

    Keywords - Biological processi

    Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciMINT1138382:GLGO-4222-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    ORF Names:OCO_41790Imported
    OrganismiMycobacterium intracellulare MOTT-02Imported
    Taxonomic identifieri1138382 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
    ProteomesiUP000008002: Chromosome

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni101 – 1077Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11822. PTHR11822. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H8IZR4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSPGSKEAK IKVKGRVVEL DGDEMTRVIW KLIKDQLILP HLDIDLDYYD    50
    LGIEHRDRTD DQVTIDAAYA IKKHGVGVKC ATITPDEARV SEFNLKKMWL 100
    SPNGTIRNIL GGTIFREPIV ISNVPRLVPG WTKPIVIGRH AFGDQYRATN 150
    FKVDKPGTVA ITFTPADGSE PMVHEMVSLP DDGGVVMGMY NFKDSVRDFA 200
    RASFKYGLNA KWPVYLSTKN TILKAYDGMF KDEFQRIYDE EFKEQFEAEG 250
    LTYEHRLIDD MVAACLKWEG GYVWACKNYD GDVQSDAIAQ GYGSLGLMTS 300
    VLMTADGKTV EAEAAHGTVT RHFRQYQAGK PTSTNPIASI FAWTRGLAHR 350
    GKLDDTPEVV EFAQTLENVV VSTVDSGKMT KDLAILIGPD QEWQQSEEFL 400
    DSIAENLEKE LAS 413
    Length:413
    Mass (Da):46,119
    Last modified:May 16, 2012 - v1
    Checksum:iDF4FD421A442F3B9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003323 Genomic DNA. Translation: AFC50542.1.
    RefSeqiYP_005344863.1. NC_016947.1.

    Genome annotation databases

    EnsemblBacteriaiAFC50542; AFC50542; OCO_41790.
    GeneIDi11905735.
    KEGGimit:OCO_41790.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003323 Genomic DNA. Translation: AFC50542.1 .
    RefSeqi YP_005344863.1. NC_016947.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFC50542 ; AFC50542 ; OCO_41790 .
    GeneIDi 11905735.
    KEGGi mit:OCO_41790.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci MINT1138382:GLGO-4222-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR004790. Isocitrate_DH_NADP.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11822. PTHR11822. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000108. IDH_NADP. 1 hit.
    TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete Genome Sequence of Mycobacterium intracellulare Clinical Strain MOTT-02."
      Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J., Kook Y.H., Kim B.J.
      J. Bacteriol. 194:2771-2771(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MOTT-02Imported.

    Entry informationi

    Entry nameiH8IZR4_MYCIT
    AccessioniPrimary (citable) accession number: H8IZR4
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 16, 2012
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 15 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3