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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Mycobacterium intracellulare (strain ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei164UniRule annotation1
Active sitei596UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotationSAAS annotationImported
Biological processCarbon dioxide fixationUniRule annotationSAAS annotation
LigandMagnesiumUniRule annotationSAAS annotation, PyruvateImported

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:OCU_31780Imported
OrganismiMycobacterium intracellulare (strain ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600)Imported
Taxonomic identifieri487521 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
Proteomesi
  • UP000008004 Componenti: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotationSAAS annotation

Phylogenomic databases

KOiK01595
OMAiPWVFGWT
OrthoDBiPOG091H040O

Family and domain databases

HAMAPiMF_00595 PEPcase_type1, 1 hit
InterProiView protein in InterPro
IPR021135 PEP_COase
IPR022805 PEP_COase_bac/pln-type
IPR018129 PEP_COase_Lys_AS
IPR033129 PEPCASE_His_AS
IPR015813 Pyrv/PenolPyrv_Kinase-like_dom
PANTHERiPTHR30523 PTHR30523, 1 hit
PfamiView protein in Pfam
PF00311 PEPcase, 1 hit
PRINTSiPR00150 PEPCARBXLASE
SUPFAMiSSF51621 SSF51621, 1 hit
PROSITEiView protein in PROSITE
PS00781 PEPCASE_1, 1 hit
PS00393 PEPCASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

H8IT46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADASEAPED TLEPIGAVQR TPVGREATEP MRADIRLLGA ILGDTVREQN
60 70 80 90 100
GREVFELVER ARVESFRVRR SEIDRAELAR MFFRIDIHQA IPVIRAFSHF
110 120 130 140 150
ALLANVAEDI HRERRRAVHV AAGEPPPDST LAATYAKLDE AQLDSDTVAD
160 170 180 190 200
ALKGAVVAPV ITAHPTETRR RTVFVTQHRI TELMRLHAEG HAETDDGRNI
210 220 230 240 250
ELELRRQVLT LWQTALIRLS RLQITDEIEV GLRYYAAAFF KVIPQVNAEV
260 270 280 290 300
RDALRARWPD ADLFDEPMLQ PGSWIGGDRD GNPNVTADVV RQATGSAAFT
310 320 330 340 350
ALAHYLAELT ALEQELSMSA RLVSVTPALT ELAGGCAEKA RADEPYRRAV
360 370 380 390 400
RVIRARLSAT SAAILDRTPQ QVLDLGLPPY ETPAELGADL DTIDESLRGH
410 420 430 440 450
GSALLADDRL ALLREGVRVF GFHLCGLDMR QNSDAHEEVI CELLAWAGVH
460 470 480 490 500
PDYRSLPEDE RVELLAAELG TRRPLVADDA QLSDLARGEL GVVRAAAHAI
510 520 530 540 550
KRYGPSAVPN YVISMCRSVS DVLEAAILLK EAGLIDASGP EPYCPVGISP
560 570 580 590 600
LFETIDDLHN GATILHAILE LPIYRALVAA RGETQEVMLG YSDSNKDGGY
610 620 630 640 650
LASSWAVYRA ELALVEVARK TGIRLRLFHG RGGTVGRGGG PSYEAILAQP
660 670 680 690 700
PGAVNGSLRL TEQGEVIAAK YAEPQAAQRN LESLLAATLE STLLDVEGLG
710 720 730 740 750
DAAEPAYAVL DEVAVLAQRA YAELVHDTPG FVDYFMASTP VSEIGSLNIG
760 770 780 790 800
SRPTSRKPTE SISDLRAIPW VLAWSQSRVM LPGWYGTGSA FEQWIAAGPQ
810 820 830 840 850
SEAERVSILH DLYQRWPFFR SVLSNLAQVL AKSDLGLAAR YAELVDDEEL
860 870 880 890 900
RRRVFDKIVD EHGRTIAMHK LITGQDNLLA DNPALARSVF NRFPYLEPLN
910 920 930
HLQVELLRRY RSGDDDELVQ RGILLTMNGL ASALRNSG
Length:938
Mass (Da):102,846
Last modified:May 16, 2012 - v1
Checksum:i5BA3EAF6CEDCF0C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003322 Genomic DNA Translation: AFC44397.1
RefSeqiWP_014380460.1, NC_016946.1

Genome annotation databases

EnsemblBacteriaiAFC44397; AFC44397; OCU_31780
GeneIDi11909920
KEGGimia:OCU_31780
PATRICifig|487521.10.peg.3188

Similar proteinsi

Entry informationi

Entry nameiH8IT46_MYCIA
AccessioniPrimary (citable) accession number: H8IT46
Entry historyiIntegrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: March 28, 2018
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health