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H8IT46

- H8IT46_MYCIA

UniProt

H8IT46 - H8IT46_MYCIA

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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Mycobacterium intracellulare (strain ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Magnesium.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641UniRule annotation
Active sitei596 – 5961UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciMINT487521:GLGN-3213-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotation
Ordered Locus Names:OCU_31780Imported
OrganismiMycobacterium intracellulare (strain ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600)Imported
Taxonomic identifieri487521 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000008004: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8IT46-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADASEAPED TLEPIGAVQR TPVGREATEP MRADIRLLGA ILGDTVREQN
60 70 80 90 100
GREVFELVER ARVESFRVRR SEIDRAELAR MFFRIDIHQA IPVIRAFSHF
110 120 130 140 150
ALLANVAEDI HRERRRAVHV AAGEPPPDST LAATYAKLDE AQLDSDTVAD
160 170 180 190 200
ALKGAVVAPV ITAHPTETRR RTVFVTQHRI TELMRLHAEG HAETDDGRNI
210 220 230 240 250
ELELRRQVLT LWQTALIRLS RLQITDEIEV GLRYYAAAFF KVIPQVNAEV
260 270 280 290 300
RDALRARWPD ADLFDEPMLQ PGSWIGGDRD GNPNVTADVV RQATGSAAFT
310 320 330 340 350
ALAHYLAELT ALEQELSMSA RLVSVTPALT ELAGGCAEKA RADEPYRRAV
360 370 380 390 400
RVIRARLSAT SAAILDRTPQ QVLDLGLPPY ETPAELGADL DTIDESLRGH
410 420 430 440 450
GSALLADDRL ALLREGVRVF GFHLCGLDMR QNSDAHEEVI CELLAWAGVH
460 470 480 490 500
PDYRSLPEDE RVELLAAELG TRRPLVADDA QLSDLARGEL GVVRAAAHAI
510 520 530 540 550
KRYGPSAVPN YVISMCRSVS DVLEAAILLK EAGLIDASGP EPYCPVGISP
560 570 580 590 600
LFETIDDLHN GATILHAILE LPIYRALVAA RGETQEVMLG YSDSNKDGGY
610 620 630 640 650
LASSWAVYRA ELALVEVARK TGIRLRLFHG RGGTVGRGGG PSYEAILAQP
660 670 680 690 700
PGAVNGSLRL TEQGEVIAAK YAEPQAAQRN LESLLAATLE STLLDVEGLG
710 720 730 740 750
DAAEPAYAVL DEVAVLAQRA YAELVHDTPG FVDYFMASTP VSEIGSLNIG
760 770 780 790 800
SRPTSRKPTE SISDLRAIPW VLAWSQSRVM LPGWYGTGSA FEQWIAAGPQ
810 820 830 840 850
SEAERVSILH DLYQRWPFFR SVLSNLAQVL AKSDLGLAAR YAELVDDEEL
860 870 880 890 900
RRRVFDKIVD EHGRTIAMHK LITGQDNLLA DNPALARSVF NRFPYLEPLN
910 920 930
HLQVELLRRY RSGDDDELVQ RGILLTMNGL ASALRNSG
Length:938
Mass (Da):102,846
Last modified:May 16, 2012 - v1
Checksum:i5BA3EAF6CEDCF0C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003322 Genomic DNA. Translation: AFC44397.1.
RefSeqiYP_005338718.1. NC_016946.1.

Genome annotation databases

EnsemblBacteriaiAFC44397; AFC44397; OCU_31780.
GeneIDi11909920.
KEGGimia:OCU_31780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003322 Genomic DNA. Translation: AFC44397.1 .
RefSeqi YP_005338718.1. NC_016946.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFC44397 ; AFC44397 ; OCU_31780 .
GeneIDi 11909920.
KEGGi mia:OCU_31780.

Phylogenomic databases

KOi K01595.

Enzyme and pathway databases

BioCyci MINT487521:GLGN-3213-MONOMER.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Mycobacterium intracellulare strain ATCC 13950T."
    Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J., Kook Y.H., Kim B.J.
    J. Bacteriol. 194:2750-2750(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600Imported.

Entry informationi

Entry nameiH8IT46_MYCIA
AccessioniPrimary (citable) accession number: H8IT46
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: October 29, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3