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H8IQQ0

- H8IQQ0_MYCIA

UniProt

H8IQQ0 - H8IQQ0_MYCIA

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Protein

Alanine racemase

Gene
OCU_42370
Organism
Mycobacterium intracellulare (strain ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei76 – 761Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei174 – 1741Substrate By similarityUniRule annotation
Active sitei305 – 3051Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei353 – 3531Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciMINT487521:GLGN-4280-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:OCU_42370Imported
OrganismiMycobacterium intracellulare (strain ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600)Imported
Taxonomic identifieri487521 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
ProteomesiUP000008004: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei76 – 761N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliH8IQQ0.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

KOiK01775.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8IQQ0-1 [UniParc]FASTAAdd to Basket

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MELLRRSRRN LANKSTLGGV RRGSGTMAPM TGRAATPISL TPGLLAEALV    50
DLGAIAHNVR LLCEQAGGAQ VMAVVKADGY GHGAAQTARA ALAAGAAELG 100
VATVDEALAL RADGVRAPVL AWLHPPGFDF GPALLADVQI AVSSERQLDE 150
LLDAVRRTGR TATVTVKVDT GLNRNGVPPE HYPSMLTALR RAVAENAIVL 200
RGLMSHMVYA DQPANPVNDL QAQRFTEMLA QARDQGVRYE AAHLSNSSAT 250
MSRPDLAFDM VRPGIAVYGL SPVPERGDMG LIPAMTVKCP VALVKSIRAG 300
ESVSYGHTWT ARRDTTLALL PVGYADGVFR SLGNRLEVLI NGRRRPGVGR 350
ICMDQFVVDL GPGPTDVAEG DEAILFGPGA SGEPTAQDWA DLLGTIHYEV 400
VTSPRGRITR TYREARTIEP 420
Length:420
Mass (Da):44,587
Last modified:May 16, 2012 - v1
Checksum:i0E5E87B2D553D341
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003322 Genomic DNA. Translation: AFC45456.1.
RefSeqiYP_005339777.1. NC_016946.1.

Genome annotation databases

EnsemblBacteriaiAFC45456; AFC45456; OCU_42370.
GeneIDi11910992.
KEGGimia:OCU_42370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003322 Genomic DNA. Translation: AFC45456.1 .
RefSeqi YP_005339777.1. NC_016946.1.

3D structure databases

ProteinModelPortali H8IQQ0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFC45456 ; AFC45456 ; OCU_42370 .
GeneIDi 11910992.
KEGGi mia:OCU_42370.

Phylogenomic databases

KOi K01775.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci MINT487521:GLGN-4280-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Mycobacterium intracellulare strain ATCC 13950T."
    Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J., Kook Y.H., Kim B.J.
    J. Bacteriol. 194:2750-2750(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600.

Entry informationi

Entry nameiH8IQQ0_MYCIA
AccessioniPrimary (citable) accession number: H8IQQ0
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: July 9, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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