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H8IQQ0

- H8IQQ0_MYCIA

UniProt

H8IQQ0 - H8IQQ0_MYCIA

Protein

Alanine racemase

Gene

OCU_42370

Organism
Mycobacterium intracellulare (strain ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 18 (01 Oct 2014)
      Sequence version 1 (16 May 2012)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotationSAAS annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei76 – 761Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei174 – 1741SubstrateUniRule annotation
    Active sitei305 – 3051Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei353 – 3531Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: UniProtKB-HAMAP
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotationImported

    Keywords - Ligandi

    Pyridoxal phosphateUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciMINT487521:GLGN-4280-MONOMER.
    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Ordered Locus Names:OCU_42370Imported
    OrganismiMycobacterium intracellulare (strain ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600)Imported
    Taxonomic identifieri487521 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium avium complex (MAC)
    ProteomesiUP000008004: Chromosome

    PTM / Processingi

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei76 – 761N6-(pyridoxal phosphate)lysineUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliH8IQQ0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    KOiK01775.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H8IQQ0-1 [UniParc]FASTAAdd to Basket

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    MELLRRSRRN LANKSTLGGV RRGSGTMAPM TGRAATPISL TPGLLAEALV    50
    DLGAIAHNVR LLCEQAGGAQ VMAVVKADGY GHGAAQTARA ALAAGAAELG 100
    VATVDEALAL RADGVRAPVL AWLHPPGFDF GPALLADVQI AVSSERQLDE 150
    LLDAVRRTGR TATVTVKVDT GLNRNGVPPE HYPSMLTALR RAVAENAIVL 200
    RGLMSHMVYA DQPANPVNDL QAQRFTEMLA QARDQGVRYE AAHLSNSSAT 250
    MSRPDLAFDM VRPGIAVYGL SPVPERGDMG LIPAMTVKCP VALVKSIRAG 300
    ESVSYGHTWT ARRDTTLALL PVGYADGVFR SLGNRLEVLI NGRRRPGVGR 350
    ICMDQFVVDL GPGPTDVAEG DEAILFGPGA SGEPTAQDWA DLLGTIHYEV 400
    VTSPRGRITR TYREARTIEP 420
    Length:420
    Mass (Da):44,587
    Last modified:May 16, 2012 - v1
    Checksum:i0E5E87B2D553D341
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003322 Genomic DNA. Translation: AFC45456.1.
    RefSeqiYP_005339777.1. NC_016946.1.

    Genome annotation databases

    EnsemblBacteriaiAFC45456; AFC45456; OCU_42370.
    GeneIDi11910992.
    KEGGimia:OCU_42370.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003322 Genomic DNA. Translation: AFC45456.1 .
    RefSeqi YP_005339777.1. NC_016946.1.

    3D structure databases

    ProteinModelPortali H8IQQ0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFC45456 ; AFC45456 ; OCU_42370 .
    GeneIDi 11910992.
    KEGGi mia:OCU_42370.

    Phylogenomic databases

    KOi K01775.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .
    BioCyci MINT487521:GLGN-4280-MONOMER.

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete genome sequence of Mycobacterium intracellulare strain ATCC 13950T."
      Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J., Kook Y.H., Kim B.J.
      J. Bacteriol. 194:2750-2750(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600Imported.

    Entry informationi

    Entry nameiH8IQQ0_MYCIA
    AccessioniPrimary (citable) accession number: H8IQQ0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 16, 2012
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 18 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3