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H8II66 (H8II66_MYCIA) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 15. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain164 – 371208ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding192 – 24756ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3261Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3381Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3381Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3401Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
H8II66 [UniParc].

Last modified May 16, 2012. Version 1.
Checksum: B5ED3C3648AFF434

FASTA38140,130
        10         20         30         40         50         60 
MNASDRSTPH PGSGGGERAR VAVVFGGRSN EHAISCVSAG SILRNLDPER FEVVAIGITP 

        70         80         90        100        110        120 
EGSWVLTDGD PAALAITDRR LPEVTAESGT ELALPADPRR GGQLVALPPG AGEVLASVDV 

       130        140        150        160        170        180 
VFPVLHGPYG EDGTIQGLLE LAGVPYVGAG VLASAAGMDK EFTKKLFAAE GLPVGDYAVL 

       190        200        210        220        230        240 
RPSRARLRPE ECQRLGLPVF VKPARGGSSI GVSRVASWDQ LDAAVAAARR HDPKVIVEAA 

       250        260        270        280        290        300 
IVGRELECGV LEMPDGTVEA SALGEIRVAG VRGREDSFYD FATKYLDDAA ELDVPAKVDD 

       310        320        330        340        350        360 
EIADTVRQLA VRAFKAIDCQ GLARVDFFLT EDGPVLNEIN TMPGFTTISM YPRMWAASGV 

       370        380 
DYPTLLATMV ETALARGVGL R 

« Hide

References

[1]"Complete genome sequence of Mycobacterium intracellulare strain ATCC 13950T."
Kim B.J., Choi B.S., Lim J.S., Choi I.Y., Lee J.H., Chun J., Kook Y.H., Kim B.J.
J. Bacteriol. 194:2750-2750(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 13950 / DSM 43223 / JCM 6384 / NCTC 13025 / 3600.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003322 Genomic DNA. Translation: AFC44873.1.
RefSeqYP_005339194.1. NC_016946.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFC44873; AFC44873; OCU_36540.
GeneID11910401.
KEGGmia:OCU_36540.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01921.

Enzyme and pathway databases

BioCycMINT487521:GLGN-3693-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH8II66_MYCIA
AccessionPrimary (citable) accession number: H8II66
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: June 11, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)