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H8HX90

- H8HX90_MYCTX

UniProt

H8HX90 - H8HX90_MYCTX

Protein

Probable DNA ligase

Gene

ligB

Organism
Mycobacterium tuberculosis RGTB423
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 17 (01 Oct 2014)
      Sequence version 1 (16 May 2012)
      Previous versions | rss
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    Functioni

    DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.UniRule annotation

    Catalytic activityi

    ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

    Cofactori

    Divalent metal cations.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei209 – 2091ATPUniRule annotation
    Active sitei211 – 2111N6-AMP-lysine intermediateUniRule annotation
    Binding sitei216 – 2161ATPUniRule annotation
    Binding sitei231 – 2311ATPUniRule annotation
    Binding sitei260 – 2601ATPUniRule annotation
    Binding sitei300 – 3001ATPUniRule annotation
    Binding sitei372 – 3721ATPUniRule annotation
    Binding sitei378 – 3781ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. DNA binding Source: InterPro
    3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
    4. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cell cycle Source: UniProtKB-KW
    2. cell division Source: UniProtKB-KW
    3. DNA ligation involved in DNA repair Source: InterPro
    4. DNA recombination Source: UniProtKB-HAMAP
    5. DNA replication Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    LigaseUniRule annotationImported

    Keywords - Biological processi

    Cell cycle, Cell divisionUniRule annotation, DNA damage, DNA recombinationUniRule annotation, DNA repairUniRule annotation, DNA replicationUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMTUB1091501:GLGZ-2863-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable DNA ligaseUniRule annotation (EC:6.5.1.1UniRule annotation)
    Alternative name(s):
    Polydeoxyribonucleotide synthase [ATP]UniRule annotation
    Gene namesi
    Name:ligBImported
    Synonyms:ligUniRule annotation
    ORF Names:MRGA423_19070Imported
    OrganismiMycobacterium tuberculosis RGTB423Imported
    Taxonomic identifieri1091501 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000007577: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliH8HX90.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ATP-dependent DNA ligase family.UniRule annotation

    Family and domain databases

    Gene3Di1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPiMF_00407. DNA_ligase.
    InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsiTIGR00574. dnl1. 1 hit.
    PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H8HX90-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLHDVAITS MDVAATSSRL TKVARIAALL HRAAPDTQLV TIIVSWLSGE    50
    LPQRHIGVGW AALRSLPPPA PQPALTVTGV DATLSKIGTL SGKGSQAQRA 100
    ALVAELFSAA TEAEQTFLLR LLGGELRQGA KGGIMADAVA QAAGLPAATV 150
    QRAAMLGGDL AAAAAAGLSG AALDTFTLRV GRPIGPMLAQ TATSVHDALE 200
    RHGGTTIFEA KLDGARVQIH RANDQVRIYT RSLDDVTARL PEVVEATLAL 250
    PVRDLVADGE AIALCPDNRP QRFQVTASRF GRSVDVAAAR ATQPLSVFFF 300
    DILHRDGTDL LEAPTTERLA ALDALVPARH RVDRLITSDP TDAANFLDAT 350
    LAAGHEGVMA KAPAARYLAG RRGAGWLKVK PVHTLDLVVL AVEWGSGRRR 400
    GKLSNIHLGA RDPATGGFVM VGKTFKGMTD AMLDWQTTRF HEIAVGPTDG 450
    YVVQLRPEQV VEVALDGVQR SSRYPGGLAL RFARVVRYRA DKDPAEADTI 500
    DAVRALY 507
    Length:507
    Mass (Da):53,727
    Last modified:May 16, 2012 - v1
    Checksum:i8D73EB4C08C7149D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003234 Genomic DNA. Translation: AFE14197.1.

    Genome annotation databases

    EnsemblBacteriaiAFE14197; AFE14197; MRGA423_19070.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003234 Genomic DNA. Translation: AFE14197.1 .

    3D structure databases

    ProteinModelPortali H8HX90.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFE14197 ; AFE14197 ; MRGA423_19070 .

    Enzyme and pathway databases

    BioCyci MTUB1091501:GLGZ-2863-MONOMER.

    Family and domain databases

    Gene3Di 1.10.3260.10. 1 hit.
    2.40.50.140. 1 hit.
    HAMAPi MF_00407. DNA_ligase.
    InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
    IPR000977. DNA_ligase_ATP-dep.
    IPR012309. DNA_ligase_ATP-dep_C.
    IPR012310. DNA_ligase_ATP-dep_cent.
    IPR016059. DNA_ligase_ATP-dep_CS.
    IPR012308. DNA_ligase_ATP-dep_N.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF04679. DNA_ligase_A_C. 1 hit.
    PF01068. DNA_ligase_A_M. 1 hit.
    PF04675. DNA_ligase_A_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF117018. SSF117018. 1 hit.
    SSF50249. SSF50249. 1 hit.
    TIGRFAMsi TIGR00574. dnl1. 1 hit.
    PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
    PS50160. DNA_LIGASE_A3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Whole-Genome Sequences of Two Clinical Isolates of Mycobacterium tuberculosis from Kerala, South India."
      Madhavilatha G.K., Joseph B.V., Paul L.K., Kumar R.A., Hariharan R., Mundayoor S.
      J. Bacteriol. 194:4430-4430(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: RGTB423Imported.

    Entry informationi

    Entry nameiH8HX90_MYCTX
    AccessioniPrimary (citable) accession number: H8HX90
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 16, 2012
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 17 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3