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H8HM04

- H8HM04_MYCTX

UniProt

H8HM04 - H8HM04_MYCTX

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Protein

Isocitrate dehydrogenase [NADP]

Gene

MRGA327_20585

Organism
Mycobacterium tuberculosis RGTB327
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801SubstrateUniRule annotation
Binding sitei85 – 851NADPUniRule annotation
Binding sitei112 – 1121Substrate
Binding sitei135 – 1351Substrate
Sitei142 – 1421Critical for catalysisUniRule annotation
Sitei215 – 2151Critical for catalysisUniRule annotation
Metal bindingi255 – 2551Magnesium or manganeseUniRule annotation
Binding sitei263 – 2631NADPUniRule annotation
Metal bindingi278 – 2781Magnesium or manganeseUniRule annotation
Binding sitei331 – 3311NADP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi78 – 803NADPUniRule annotation
Nucleotide bindingi313 – 3186NADPUniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciMTUB1091500:GLGW-3178-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:MRGA327_20585Imported
OrganismiMycobacterium tuberculosis RGTB327Imported
Taxonomic identifieri1091500 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000007578: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiH8HM04.

Structurei

3D structure databases

ProteinModelPortaliH8HM04.
SMRiH8HM04. Positions 5-406.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 1037Substrate binding

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8HM04-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MSNAPKIKVS GPVVELDGDE MTRVIWKLIK DMLILPYLDI RLDYYDLGIE
60 70 80 90 100
HRDATDDQVT IDAAYAIKKH GVGVKCATIT PDEARVEEFN LKKMWLSPNG
110 120 130 140 150
TIRNILGGTI FREPIVISNV PRLVPGWTKP IVIGRHAFGD QYRATNFKVD
160 170 180 190 200
QPGTVTLTFT PADGSAPIVH EMVSIPEDGG VVLGMYNFKE SIRDFARASF
210 220 230 240 250
SYGLNAKWPV YLSTKNTILK AYDGMFKDEF ERVYEEEFKA QFEAAGLTYE
260 270 280 290 300
HRLIDDMVAA CLKWEGGYVW ACKNYDGDVQ SDTVAQGYGS LGLMTSVLMT
310 320 330 340 350
ADGKTVEAEA AHGTVTRHYR QYQAGKPTST NPIASIFAWT RGLQHRGKLD
360 370 380 390 400
GTPEVIDFAH KLESVVIATV ESGKMTKDLA ILIGPEQDWL NSEEFLDAIA

DNLEKELAN
Length:409
Mass (Da):45,514
Last modified:May 16, 2012 - v1
Checksum:iFDBC1989DF42383A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003233 Genomic DNA. Translation: AFE18132.1.

Genome annotation databases

EnsemblBacteriaiAFE18132; AFE18132; MRGA327_20585.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003233 Genomic DNA. Translation: AFE18132.1 .

3D structure databases

ProteinModelPortali H8HM04.
SMRi H8HM04. Positions 5-406.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi H8HM04.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFE18132 ; AFE18132 ; MRGA327_20585 .

Phylogenomic databases

OMAi KNTIMKV.

Enzyme and pathway databases

BioCyci MTUB1091500:GLGW-3178-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-Genome Sequences of Two Clinical Isolates of Mycobacterium tuberculosis from Kerala, South India."
    Madhavilatha G.K., Joseph B.V., Paul L.K., Kumar R.A., Hariharan R., Mundayoor S.
    J. Bacteriol. 194:4430-4430(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RGTB327Imported.

Entry informationi

Entry nameiH8HM04_MYCTX
AccessioniPrimary (citable) accession number: H8HM04
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: October 29, 2014
This is version 23 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3