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H8HM04 (H8HM04_MYCTX) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 20. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein attributes

Sequence length409 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. RuleBase RU004443 PIRNR PIRNR000108

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding78 – 803NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding313 – 3186NADP By similarity PIRSR PIRSR000108-4
Region97 – 1037Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2551Magnesium or manganese By similarity
Metal binding2781Magnesium or manganese By similarity
Binding site801Substrate By similarity PIRSR PIRSR000108-2
Binding site851NADP By similarity PIRSR PIRSR000108-4
Binding site1121Substrate By similarity PIRSR PIRSR000108-2
Binding site1351Substrate By similarity PIRSR PIRSR000108-2
Binding site2631NADP By similarity PIRSR PIRSR000108-4
Binding site3311NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1421Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2151Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
H8HM04 [UniParc].

Last modified May 16, 2012. Version 1.
Checksum: FDBC1989DF42383A

FASTA40945,514
        10         20         30         40         50         60 
MSNAPKIKVS GPVVELDGDE MTRVIWKLIK DMLILPYLDI RLDYYDLGIE HRDATDDQVT 

        70         80         90        100        110        120 
IDAAYAIKKH GVGVKCATIT PDEARVEEFN LKKMWLSPNG TIRNILGGTI FREPIVISNV 

       130        140        150        160        170        180 
PRLVPGWTKP IVIGRHAFGD QYRATNFKVD QPGTVTLTFT PADGSAPIVH EMVSIPEDGG 

       190        200        210        220        230        240 
VVLGMYNFKE SIRDFARASF SYGLNAKWPV YLSTKNTILK AYDGMFKDEF ERVYEEEFKA 

       250        260        270        280        290        300 
QFEAAGLTYE HRLIDDMVAA CLKWEGGYVW ACKNYDGDVQ SDTVAQGYGS LGLMTSVLMT 

       310        320        330        340        350        360 
ADGKTVEAEA AHGTVTRHYR QYQAGKPTST NPIASIFAWT RGLQHRGKLD GTPEVIDFAH 

       370        380        390        400 
KLESVVIATV ESGKMTKDLA ILIGPEQDWL NSEEFLDAIA DNLEKELAN 

« Hide

References

[1]"Whole-Genome Sequences of Two Clinical Isolates of Mycobacterium tuberculosis from Kerala, South India."
Madhavilatha G.K., Joseph B.V., Paul L.K., Kumar R.A., Hariharan R., Mundayoor S.
J. Bacteriol. 194:4430-4430(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: RGTB327 EMBL AFE18132.1.
[2]Madhavilatha K.G., Joseph B.V., Paul L.K., Kumar A.R., Hariharan R., Mundayoor S.
Submitted (MAR-2012) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: RGTB327 EMBL AFE18132.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003233 Genomic DNA. Translation: AFE18132.1.

3D structure databases

ProteinModelPortalH8HM04.
SMRH8HM04. Positions 5-406.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEH8HM04.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFE18132; AFE18132; MRGA327_20585.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMAKNTIMKV.

Enzyme and pathway databases

BioCycMTUB1091500:GLGW-3178-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH8HM04_MYCTX
AccessionPrimary (citable) accession number: H8HM04
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: July 9, 2014
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)