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H8HM04

- H8HM04_MYCTX

UniProt

H8HM04 - H8HM04_MYCTX

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Protein
Isocitrate dehydrogenase [NADP]
Gene
MRGA327_20585
Organism
Mycobacterium tuberculosis RGTB327
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801Substrate By similarityUniRule annotation
Binding sitei85 – 851NADP By similarityUniRule annotation
Binding sitei112 – 1121Substrate By similarityUniRule annotation
Binding sitei135 – 1351Substrate By similarityUniRule annotation
Sitei142 – 1421Critical for catalysis By similarityUniRule annotation
Sitei215 – 2151Critical for catalysis By similarityUniRule annotation
Metal bindingi255 – 2551Magnesium or manganese By similarity
Binding sitei263 – 2631NADP By similarityUniRule annotation
Metal bindingi278 – 2781Magnesium or manganese By similarity
Binding sitei331 – 3311NADP; via amide nitrogen and carbonyl oxygen By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi78 – 803NADP By similarityUniRule annotation
Nucleotide bindingi313 – 3186NADP By similarityUniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: InterPro
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciMTUB1091500:GLGW-3178-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:MRGA327_20585Imported
OrganismiMycobacterium tuberculosis RGTB327Imported
Taxonomic identifieri1091500 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000007578: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiH8HM04.

Structurei

3D structure databases

ProteinModelPortaliH8HM04.
SMRiH8HM04. Positions 5-406.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni97 – 1037Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

OMAiKNTIMKV.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11822. PTHR11822. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsiTIGR00127. nadp_idh_euk. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8HM04-1 [UniParc]FASTAAdd to Basket

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MSNAPKIKVS GPVVELDGDE MTRVIWKLIK DMLILPYLDI RLDYYDLGIE    50
HRDATDDQVT IDAAYAIKKH GVGVKCATIT PDEARVEEFN LKKMWLSPNG 100
TIRNILGGTI FREPIVISNV PRLVPGWTKP IVIGRHAFGD QYRATNFKVD 150
QPGTVTLTFT PADGSAPIVH EMVSIPEDGG VVLGMYNFKE SIRDFARASF 200
SYGLNAKWPV YLSTKNTILK AYDGMFKDEF ERVYEEEFKA QFEAAGLTYE 250
HRLIDDMVAA CLKWEGGYVW ACKNYDGDVQ SDTVAQGYGS LGLMTSVLMT 300
ADGKTVEAEA AHGTVTRHYR QYQAGKPTST NPIASIFAWT RGLQHRGKLD 350
GTPEVIDFAH KLESVVIATV ESGKMTKDLA ILIGPEQDWL NSEEFLDAIA 400
DNLEKELAN 409
Length:409
Mass (Da):45,514
Last modified:May 16, 2012 - v1
Checksum:iFDBC1989DF42383A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003233 Genomic DNA. Translation: AFE18132.1.

Genome annotation databases

EnsemblBacteriaiAFE18132; AFE18132; MRGA327_20585.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003233 Genomic DNA. Translation: AFE18132.1 .

3D structure databases

ProteinModelPortali H8HM04.
SMRi H8HM04. Positions 5-406.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi H8HM04.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFE18132 ; AFE18132 ; MRGA327_20585 .

Phylogenomic databases

OMAi KNTIMKV.

Enzyme and pathway databases

BioCyci MTUB1091500:GLGW-3178-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11822. PTHR11822. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsi TIGR00127. nadp_idh_euk. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Whole-Genome Sequences of Two Clinical Isolates of Mycobacterium tuberculosis from Kerala, South India."
    Madhavilatha G.K., Joseph B.V., Paul L.K., Kumar R.A., Hariharan R., Mundayoor S.
    J. Bacteriol. 194:4430-4430(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RGTB327Imported.

Entry informationi

Entry nameiH8HM04_MYCTX
AccessioniPrimary (citable) accession number: H8HM04
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: September 3, 2014
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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