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H8HHL7 (H8HHL7_STRPY) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoenolpyruvate carboxylase HAMAP-Rule MF_00595

Short name=PEPC HAMAP-Rule MF_00595
Short name=PEPCase HAMAP-Rule MF_00595
EC=4.1.1.31 HAMAP-Rule MF_00595
Gene names
Name:ppc HAMAP-Rule MF_00595 EMBL AFC67751.1
ORF Names:MGAS1882_0528 EMBL AFC67751.1
OrganismStreptococcus pyogenes MGAS1882 [Complete proteome] EMBL AFC67751.1
Taxonomic identifier1010840 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus

Protein attributes

Sequence length932 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity. HAMAP-Rule MF_00595

Catalytic activity

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-. SAAS SAAS021135 HAMAP-Rule MF_00595

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00595 SAAS SAAS021135

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00595

Sequence similarities

Belongs to the PEPCase type 1 family. HAMAP-Rule MF_00595

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1501 By similarity HAMAP-Rule MF_00595
Active site5951 By similarity HAMAP-Rule MF_00595

Sequences

Sequence LengthMass (Da)Tools
H8HHL7 [UniParc].

Last modified May 16, 2012. Version 1.
Checksum: CDDBDADB3E6825A6

FASTA932106,006
        10         20         30         40         50         60 
MIEETSKEGD GHLPLKKLES SNNQAIIAEE VALLKEMLEN ITRRMIGDDA FTVIESIMVL 

        70         80         90        100        110        120 
SEKQDYIELE KVVANISNQE MEVISRYFSI LPLLINISED VDLAYEINYQ NNTNTDYLGK 

       130        140        150        160        170        180 
LALTIKDLAG KDNGKDILEQ VNVVPVLTAH PTQVQRKTIL ELTTHIHKLL RKYRDAKAGV 

       190        200        210        220        230        240 
INLEKWRQEL YRYIEMIMQT DIIREKKLQV KNEIKNVMQY YDGSLIQAVT KLTTEYKNLA 

       250        260        270        280        290        300 
QKHGLELDNP KPITMGMWIG GDRDGNPFVT AETLCLSATV QSEVILNYYI DKLAALYRTF 

       310        320        330        340        350        360 
SLSSTLVQPN SEVERLASLS QDQSIYRGNE PYRRAFHYIQ SRLKQTQIQL TNQPAARMSS 

       370        380        390        400        410        420 
SVGLNTSAWS SPASLENPIL AYDSPVDFKA DLKAIEQSLL DNGNSALIEG DLREVMQAVD 

       430        440        450        460        470        480 
IFGFFLASID MRQDSSVQEA CVAELLKGAN IVDDYSSLSE TEKCDVLLQQ LMEEPRTLSS 

       490        500        510        520        530        540 
AAVAKSDLLE KELAIYTTAR ELKDKLGEEV IKQHIISHTE SVSDMFELAI MLKEVGLVDQ 

       550        560        570        580        590        600 
QRARVQIVPL FETIEDLDNA RDIMAAYLSH DIVKSWIATN RNYQEIMLGY SDSNKDGGYL 

       610        620        630        640        650        660 
ASGWTLYKAQ NELTSIGEEH GVKITFFHGR GGTVGRGGGP SYDAITSQPF GSIKDRIRLT 

       670        680        690        700        710        720 
EQGEIIENKY GNKDVAYYHL EMLISASINR MVTQMITDPN EIDSFREIMD SIVADSNTIY 

       730        740        750        760        770        780 
RKLVFDNPHF YDYFFEASPI KEVSSLNIGS RPAARKTITE ITGLRAIPWV FSWSQNRIMF 

       790        800        810        820        830        840 
PGWYGVGSAF KRYIDRAQGN LERLQHMYQT WPFFHSLLSN VDMVLSKSNM NIAFQYAQLA 

       850        860        870        880        890        900 
ESQDVRDVFY EILDEWQLTK NVILAIQDHD DLLEDNPSLK HSLKSRLPYF NVLNYIQIEL 

       910        920        930 
IKRWRNNQLD ENDEKLIHTT INGIATGLRN SG 

« Hide

References

[1]"Full-Genome Dissection of an Epidemic of Severe Invasive Disease Caused by a Hypervirulent, Recently Emerged Clone of Group A Streptococcus."
Fittipaldi N., Beres S.B., Olsen R.J., Kapur V., Shea P.R., Watkins M.E., Cantu C.C., Laucirica D.R., Jenkin L., Flores A.R., Lovgren M., Ardanuy C., Linares J., Low D.E., Tyrrell G.J., Musser J.M.
Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MGAS1882 EMBL AFC67751.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP003121 Genomic DNA. Translation: AFC67751.1.
RefSeqYP_005411282.1. NC_017053.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFC67751; AFC67751; MGAS1882_0528.
GeneID12013816.
KEGGstx:MGAS1882_0528.

Organism-specific databases

CMRSearch...

Phylogenomic databases

KOK01595.

Enzyme and pathway databases

BioCycSPYO1010840:GLLF-528-MONOMER.

Family and domain databases

HAMAPMF_00595. PEPcase_type1.
InterProIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSPR00150. PEPCARBXLASE.
SUPFAMSSF51621. SSF51621. 1 hit.
PROSITEPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH8HHL7_STRPY
AccessionPrimary (citable) accession number: H8HHL7
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: February 19, 2014
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)