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H8HEV9

- H8HEV9_STRPY

UniProt

H8HEV9 - H8HEV9_STRPY

Protein

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase

Gene

gpmA

Organism
Streptococcus pyogenes MGAS1882
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 14 (01 Oct 2014)
      Sequence version 1 (16 May 2012)
      Previous versions | rss
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    Functioni

    Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.UniRule annotationSAAS annotation

    Catalytic activityi

    2-phospho-D-glycerate = 3-phospho-D-glycerate.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei9 – 91Tele-phosphohistidine intermediateUniRule annotation
    Binding sitei15 – 1512-phospho-D-glycerateUniRule annotation
    Binding sitei60 – 6012-phospho-D-glycerateUniRule annotation
    Binding sitei98 – 9812-phospho-D-glycerateUniRule annotation
    Active sitei182 – 1821UniRule annotation
    Binding sitei184 – 18412-phospho-D-glycerateUniRule annotation

    GO - Molecular functioni

    1. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    IsomeraseUniRule annotationSAAS annotation

    Keywords - Biological processi

    GlycolysisUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciSPYO1010840:GLLF-1098-MONOMER.
    UniPathwayiUPA00109; UER00186.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2,3-bisphosphoglycerate-dependent phosphoglycerate mutaseUniRule annotation (EC:5.4.2.11UniRule annotation)
    Short name:
    BPG-dependent PGAMUniRule annotation
    Short name:
    PGAMUniRule annotation
    Short name:
    PhosphoglyceromutaseUniRule annotation
    Short name:
    dPGMUniRule annotation
    Gene namesi
    Name:gpmAUniRule annotationImported
    ORF Names:MGAS1882_1098Imported
    OrganismiStreptococcus pyogenes MGAS1882Imported
    Taxonomic identifieri1010840 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
    ProteomesiUP000008017: Chromosome

    Structurei

    3D structure databases

    ProteinModelPortaliH8HEV9.
    SMRiH8HEV9. Positions 1-231.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni21 – 2222-phospho-D-glycerate bindingUniRule annotation
    Regioni87 – 9042-phospho-D-glycerate bindingUniRule annotation
    Regioni114 – 11522-phospho-D-glycerate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.UniRule annotation

    Phylogenomic databases

    KOiK01834.

    Family and domain databases

    Gene3Di3.40.50.1240. 1 hit.
    HAMAPiMF_01039. PGAM_GpmA.
    InterProiIPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    IPR005952. Phosphogly_mut1.
    [Graphical view]
    PANTHERiPTHR11931. PTHR11931. 1 hit.
    PfamiPF00300. His_Phos_1. 1 hit.
    [Graphical view]
    SMARTiSM00855. PGAM. 1 hit.
    [Graphical view]
    SUPFAMiSSF53254. SSF53254. 1 hit.
    TIGRFAMsiTIGR01258. pgm_1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    H8HEV9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVKLVFARHG ESEWNKANLF TGWADVDLSE KGTQQAIDAG KLIKEAGIEF    50
    DLAFTSVLTR AIKTTNLALE NAGQLWVPTE KSWRLNERHY GALTGKNKAE 100
    AAEQFGDEQV HIWRRSYDVL PPAMAKDDEY SAHKDRRYAD LDPALIPDAE 150
    NLKVTLERAM PYWEEKIAPA LLDGKNVFVG AHGNSIRALV KHIKGLSDDE 200
    IMDVEIPNFP PLVFELDEKL NIVKEYYLGG E 231
    Length:231
    Mass (Da):26,036
    Last modified:May 16, 2012 - v1
    Checksum:i853A5C7A546F2903
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003121 Genomic DNA. Translation: AFC68305.1.
    RefSeqiYP_005411837.1. NC_017053.1.

    Genome annotation databases

    EnsemblBacteriaiAFC68305; AFC68305; MGAS1882_1098.
    GeneIDi12014930.
    KEGGistx:MGAS1882_1098.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP003121 Genomic DNA. Translation: AFC68305.1 .
    RefSeqi YP_005411837.1. NC_017053.1.

    3D structure databases

    ProteinModelPortali H8HEV9.
    SMRi H8HEV9. Positions 1-231.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFC68305 ; AFC68305 ; MGAS1882_1098 .
    GeneIDi 12014930.
    KEGGi stx:MGAS1882_1098.

    Phylogenomic databases

    KOi K01834.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00186 .
    BioCyci SPYO1010840:GLLF-1098-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1240. 1 hit.
    HAMAPi MF_01039. PGAM_GpmA.
    InterProi IPR013078. His_Pase_superF_clade-1.
    IPR029033. His_PPase_superfam.
    IPR005952. Phosphogly_mut1.
    [Graphical view ]
    PANTHERi PTHR11931. PTHR11931. 1 hit.
    Pfami PF00300. His_Phos_1. 1 hit.
    [Graphical view ]
    SMARTi SM00855. PGAM. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53254. SSF53254. 1 hit.
    TIGRFAMsi TIGR01258. pgm_1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Full-Genome Dissection of an Epidemic of Severe Invasive Disease Caused by a Hypervirulent, Recently Emerged Clone of Group A Streptococcus."
      Fittipaldi N., Beres S.B., Olsen R.J., Kapur V., Shea P.R., Watkins M.E., Cantu C.C., Laucirica D.R., Jenkin L., Flores A.R., Lovgren M., Ardanuy C., Linares J., Low D.E., Tyrrell G.J., Musser J.M.
      Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: MGAS1882Imported.

    Entry informationi

    Entry nameiH8HEV9_STRPY
    AccessioniPrimary (citable) accession number: H8HEV9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 16, 2012
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 14 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3