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H8HE74

- H8HE74_STRPY

UniProt

H8HE74 - H8HE74_STRPY

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Protein

Thymidine kinase

Gene

tdk

Organism
Streptococcus pyogenes MGAS1882
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton acceptorUniRule annotation
Metal bindingi143 – 1431ZincUniRule annotation
Metal bindingi146 – 1461ZincUniRule annotation
Metal bindingi180 – 1801ZincUniRule annotation
Metal bindingi183 – 1831ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi85 – 884ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciSPYO1010840:GLLF-857-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotationImported
ORF Names:MGAS1882_0857Imported
OrganismiStreptococcus pyogenes MGAS1882Imported
Taxonomic identifieri1010840 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000008017: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliH8HE74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

KOiK00857.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8HE74-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQLYYKYGT MNSGKTIEIL KVAHNYEEQG KPVVIMTSAL DTRDGFGIVS
60 70 80 90 100
SRIGMRREAI PISNDMDIFT FIAQLEEKPY CVLIDESQFL SKQNVYDLAR
110 120 130 140 150
VVDELNVPVM AFGLKNDFQN NLFEGSKHLL LLADKIDEIK TICQYCSKKA
160 170 180
TMVLRTENGK PVYEGDQIQI GGNETYIPVC RKHYFNPEI
Length:189
Mass (Da):21,547
Last modified:May 16, 2012 - v1
Checksum:iBF895E3F609B821E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003121 Genomic DNA. Translation: AFC68071.1.
RefSeqiYP_005411602.1. NC_017053.1.

Genome annotation databases

EnsemblBacteriaiAFC68071; AFC68071; MGAS1882_0857.
GeneIDi12014145.
KEGGistx:MGAS1882_0857.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP003121 Genomic DNA. Translation: AFC68071.1 .
RefSeqi YP_005411602.1. NC_017053.1.

3D structure databases

ProteinModelPortali H8HE74.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFC68071 ; AFC68071 ; MGAS1882_0857 .
GeneIDi 12014145.
KEGGi stx:MGAS1882_0857.

Phylogenomic databases

KOi K00857.

Enzyme and pathway databases

BioCyci SPYO1010840:GLLF-857-MONOMER.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Full-Genome Dissection of an Epidemic of Severe Invasive Disease Caused by a Hypervirulent, Recently Emerged Clone of Group A Streptococcus."
    Fittipaldi N., Beres S.B., Olsen R.J., Kapur V., Shea P.R., Watkins M.E., Cantu C.C., Laucirica D.R., Jenkin L., Flores A.R., Lovgren M., Ardanuy C., Linares J., Low D.E., Tyrrell G.J., Musser J.M.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: MGAS1882Imported.

Entry informationi

Entry nameiH8HE74_STRPY
AccessioniPrimary (citable) accession number: H8HE74
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: November 26, 2014
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3