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H8HD01 (H8HD01_STRPY) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 10. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta HAMAP-Rule MF_01395
Short name=ACCase subunit beta HAMAP-Rule MF_01395
Short name=Acetyl-CoA carboxylase carboxyltransferase subunit beta HAMAP-Rule MF_01395
EC=6.4.1.2 HAMAP-Rule MF_01395
Gene names
Name:accD HAMAP-Rule MF_01395 EMBL AFC66655.1
ORF Names:MGAS15252_1331 EMBL AFC66655.1
OrganismStreptococcus pyogenes MGAS15252 EMBL AFC66655.1
Taxonomic identifier798300 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA By similarity. HAMAP-Rule MF_01395

Catalytic activity

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. HAMAP-Rule MF_01395

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP-Rule MF_01395

Pathway

Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1. HAMAP-Rule MF_01395

Subunit structure

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD) By similarity. HAMAP-Rule MF_01395

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01395 SAAS SAAS011762.

Sequence similarities

Belongs to the AccD/PCCB family. HAMAP-Rule MF_01395

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Zinc finger38 – 5922C4-type By similarity HAMAP-Rule MF_01395

Sites

Metal binding381Zinc By similarity HAMAP-Rule MF_01395
Metal binding411Zinc By similarity HAMAP-Rule MF_01395
Metal binding561Zinc By similarity HAMAP-Rule MF_01395
Metal binding591Zinc By similarity HAMAP-Rule MF_01395

Sequences

Sequence LengthMass (Da)Tools
H8HD01 [UniParc].

Last modified May 16, 2012. Version 1.
Checksum: 96D76DFAD95DEA8C

FASTA28831,766
        10         20         30         40         50         60 
MALFRKKDKY IRITPNNSLK GSVSHNVPEV PDELFAKCPA CKHMIYKKDL GLAKICPTCS 

        70         80         90        100        110        120 
YNFRISAQER LTLTVDEGSF QELFISIETK DPLRFPGYQE KLQKAKETTG LHEAVLTGKA 

       130        140        150        160        170        180 
MVKGQQIALA IMDSHFIMAS MGTVVGEKIT RLFELAIEEN LPVVIFTASG GARMQEGIMS 

       190        200        210        220        230        240 
LMQMAKVSAA VKRHSNAGLF YLTILTDPTT GGVTASFAME GDIILAEPQS LVGFAGRRVI 

       250        260        270        280 
ETTVRENLPD DFQKAEFLQD HGFVDAIVKR TELRDKIAHL VAFHGGGQ

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References

[1]"Full-genome dissection of an epidemic of severe invasive disease caused by a hypervirulent, recently emerged clone of group a streptococcus."
Fittipaldi N., Beres S.B., Olsen R.J., Kapur V., Shea P.R., Watkins M.E., Cantu C.C., Laucirica D.R., Jenkins L., Flores A.R., Lovgren M., Ardanuy C., Linares J., Low D.E., Tyrrell G.J., Musser J.M.
Am. J. Pathol. 180:1522-1534(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: MGAS15252 EMBL AFC66655.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP003116 Genomic DNA. Translation: AFC66655.1.
RefSeqYP_005389353.1. NC_017040.1.

3D structure databases

ProteinModelPortalH8HD01.
SMRH8HD01. Positions 31-286.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAFC66655; AFC66655; MGAS15252_1331.
GeneID11991630.
KEGGstg:MGAS15252_1331.

Phylogenomic databases

KOK01963.

Enzyme and pathway databases

BioCycSPYO798300:GLLE-1330-MONOMER.
UniPathwayUPA00655; UER00711.

Family and domain databases

HAMAPMF_01395. AcetylCoA_CT_beta.
InterProIPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR000022. Carboxyl_trans.
IPR011762. COA_CT_N.
[Graphical view]
PfamPF01039. Carboxyl_trans. 1 hit.
[Graphical view]
PRINTSPR01070. ACCCTRFRASEB.
TIGRFAMsTIGR00515. accD. 1 hit.
PROSITEPS50980. COA_CT_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameH8HD01_STRPY
AccessionPrimary (citable) accession number: H8HD01
Entry history
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: May 29, 2013
This is version 10 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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