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H8H966

- H8H966_STRPY

UniProt

H8H966 - H8H966_STRPY

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Protein
Phosphoenolpyruvate carboxylase
Gene
ppc, MGAS15252_0531
Organism
Streptococcus pyogenes MGAS15252
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotations

Cofactori

Magnesium By similarity.UniRule annotationSAAS annotations

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei150 – 1501 By similarityUniRule annotation
Active sitei595 – 5951 By similarityUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotations

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotations

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotations, PyruvateImported

Enzyme and pathway databases

BioCyciSPYO798300:GLLE-531-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
ORF Names:MGAS15252_0531Imported
OrganismiStreptococcus pyogenes MGAS15252Imported
Taxonomic identifieri798300 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000008016: Chromosome

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8H966-1 [UniParc]FASTAAdd to Basket

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MIEETSKEGD GHLPLKKLES SNNQAIIAEE VALLKEMLEN ITRRMIGDDA    50
FTVIESIMVL SEKQDYIELE KVVANISNQE MEVISRYFSI LPLLINISED 100
VDLAYEINYQ NNTNTDYLGK LALTIKDLAG KDNGKDILEQ VNVVPVLTAH 150
PTQVQRKTIL ELTTHIHKLL RKYRDAKAGV INLEKWRQEL YRYIEMIMQT 200
DIIREKKLQV KNEIKNVMQY YDGSLIQAVT KLTTEYKNLA QKHGLELDNP 250
KPITMGMWIG GDRDGNPFVT AETLCLSATV QSEVILNYYI DKLAALYRTF 300
SLSSTLVQPN SEVERLASLS QDQSIYRGNE PYRRAFHYIQ SRLKQTQIQL 350
TNQPAARMSS SVGLNTSAWS SPASLENPIL AYDSPVDFKA DLKAIEQSLL 400
DNGNSALIEG DLREVMQAVD IFGFFLASID MRQDSSVQEA CVAELLKGAN 450
IVDDYSSLSE TEKCDVLLQQ LMEEPRTLSS AAVAKSDLLE KELAIYTTAR 500
ELKDKLGEEV IKQHIISHTE SVSDMFELAI MLKEVGLVDQ QRARVQIVPL 550
FETIEDLDNA RDIMAAYLSH DIVKSWIATN RNYQEIMLGY SDSNKDGGYL 600
ASGWTLYKAQ NELTSIGEEH GVKITFFHGR GGTVGRGGGP SYDAITSQPF 650
GSIKDRIRLT EQGEIIENKY GNKDVAYYHL EMLISASINR MVTQMITDPN 700
EIDSFREIMD SIVADSNTIY RKLVFDNPHF YDYFFEASPI KEVSSLNIGS 750
RPAARKTITE ITGLRAIPWV FSWSQNRIMF PGWYGVGSAF KRYIDRAQGN 800
LERLQHMYQT WPFFHSLLSN VDMVLSKSNM NIAFQYAQLA ESQDVRDVFY 850
EILDEWQLTK NVILAIQDHD DLLEDNPSLK HSLKSRLPYF NVLNYIQIEL 900
IKRWRNNQLD ENDEKLIHTT INGIATGLRN SG 932
Length:932
Mass (Da):106,006
Last modified:May 16, 2012 - v1
Checksum:iCDDBDADB3E6825A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003116 Genomic DNA. Translation: AFC65882.1.
RefSeqiYP_005388580.1. NC_017040.1.

Genome annotation databases

EnsemblBacteriaiAFC65882; AFC65882; MGAS15252_0531.
GeneIDi11990467.
KEGGistg:MGAS15252_0531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003116 Genomic DNA. Translation: AFC65882.1 .
RefSeqi YP_005388580.1. NC_017040.1.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFC65882 ; AFC65882 ; MGAS15252_0531 .
GeneIDi 11990467.
KEGGi stg:MGAS15252_0531.

Phylogenomic databases

KOi K01595.

Enzyme and pathway databases

BioCyci SPYO798300:GLLE-531-MONOMER.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Full-genome dissection of an epidemic of severe invasive disease caused by a hypervirulent, recently emerged clone of group A Streptococcus."
    Fittipaldi N., Beres S.B., Olsen R.J., Kapur V., Shea P.R., Watkins M.E., Cantu C.C., Laucirica D.R., Jenkins L., Flores A.R., Lovgren M., Ardanuy C., Linares J., Low D.E., Tyrrell G.J., Musser J.M.
    Am. J. Pathol. 180:1522-1534(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS15252Imported.

Entry informationi

Entry nameiH8H966_STRPY
AccessioniPrimary (citable) accession number: H8H966
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: September 3, 2014
This is version 13 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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