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H8H966

- H8H966_STRPY

UniProt

H8H966 - H8H966_STRPY

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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Streptococcus pyogenes MGAS15252
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Magnesium.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei150 – 1501UniRule annotation
Active sitei595 – 5951UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciSPYO798300:GLLE-531-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
ORF Names:MGAS15252_0531Imported
OrganismiStreptococcus pyogenes MGAS15252Imported
Taxonomic identifieri798300 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesStreptococcaceaeStreptococcus
ProteomesiUP000008016: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

KOiK01595.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8H966-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIEETSKEGD GHLPLKKLES SNNQAIIAEE VALLKEMLEN ITRRMIGDDA
60 70 80 90 100
FTVIESIMVL SEKQDYIELE KVVANISNQE MEVISRYFSI LPLLINISED
110 120 130 140 150
VDLAYEINYQ NNTNTDYLGK LALTIKDLAG KDNGKDILEQ VNVVPVLTAH
160 170 180 190 200
PTQVQRKTIL ELTTHIHKLL RKYRDAKAGV INLEKWRQEL YRYIEMIMQT
210 220 230 240 250
DIIREKKLQV KNEIKNVMQY YDGSLIQAVT KLTTEYKNLA QKHGLELDNP
260 270 280 290 300
KPITMGMWIG GDRDGNPFVT AETLCLSATV QSEVILNYYI DKLAALYRTF
310 320 330 340 350
SLSSTLVQPN SEVERLASLS QDQSIYRGNE PYRRAFHYIQ SRLKQTQIQL
360 370 380 390 400
TNQPAARMSS SVGLNTSAWS SPASLENPIL AYDSPVDFKA DLKAIEQSLL
410 420 430 440 450
DNGNSALIEG DLREVMQAVD IFGFFLASID MRQDSSVQEA CVAELLKGAN
460 470 480 490 500
IVDDYSSLSE TEKCDVLLQQ LMEEPRTLSS AAVAKSDLLE KELAIYTTAR
510 520 530 540 550
ELKDKLGEEV IKQHIISHTE SVSDMFELAI MLKEVGLVDQ QRARVQIVPL
560 570 580 590 600
FETIEDLDNA RDIMAAYLSH DIVKSWIATN RNYQEIMLGY SDSNKDGGYL
610 620 630 640 650
ASGWTLYKAQ NELTSIGEEH GVKITFFHGR GGTVGRGGGP SYDAITSQPF
660 670 680 690 700
GSIKDRIRLT EQGEIIENKY GNKDVAYYHL EMLISASINR MVTQMITDPN
710 720 730 740 750
EIDSFREIMD SIVADSNTIY RKLVFDNPHF YDYFFEASPI KEVSSLNIGS
760 770 780 790 800
RPAARKTITE ITGLRAIPWV FSWSQNRIMF PGWYGVGSAF KRYIDRAQGN
810 820 830 840 850
LERLQHMYQT WPFFHSLLSN VDMVLSKSNM NIAFQYAQLA ESQDVRDVFY
860 870 880 890 900
EILDEWQLTK NVILAIQDHD DLLEDNPSLK HSLKSRLPYF NVLNYIQIEL
910 920 930
IKRWRNNQLD ENDEKLIHTT INGIATGLRN SG
Length:932
Mass (Da):106,006
Last modified:May 16, 2012 - v1
Checksum:iCDDBDADB3E6825A6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003116 Genomic DNA. Translation: AFC65882.1.
RefSeqiWP_014407425.1. NC_017040.1.
YP_005388580.1. NC_017040.1.

Genome annotation databases

EnsemblBacteriaiAFC65882; AFC65882; MGAS15252_0531.
GeneIDi11990467.
KEGGistg:MGAS15252_0531.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP003116 Genomic DNA. Translation: AFC65882.1 .
RefSeqi WP_014407425.1. NC_017040.1.
YP_005388580.1. NC_017040.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFC65882 ; AFC65882 ; MGAS15252_0531 .
GeneIDi 11990467.
KEGGi stg:MGAS15252_0531.

Phylogenomic databases

KOi K01595.

Enzyme and pathway databases

BioCyci SPYO798300:GLLE-531-MONOMER.

Family and domain databases

HAMAPi MF_00595. PEPcase_type1.
InterProi IPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF00311. PEPcase. 1 hit.
[Graphical view ]
PRINTSi PR00150. PEPCARBXLASE.
SUPFAMi SSF51621. SSF51621. 1 hit.
PROSITEi PS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Full-genome dissection of an epidemic of severe invasive disease caused by a hypervirulent, recently emerged clone of group A Streptococcus."
    Fittipaldi N., Beres S.B., Olsen R.J., Kapur V., Shea P.R., Watkins M.E., Cantu C.C., Laucirica D.R., Jenkins L., Flores A.R., Lovgren M., Ardanuy C., Linares J., Low D.E., Tyrrell G.J., Musser J.M.
    Am. J. Pathol. 180:1522-1534(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MGAS15252Imported.

Entry informationi

Entry nameiH8H966_STRPY
AccessioniPrimary (citable) accession number: H8H966
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: October 29, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3