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H8H6L2

- H8H6L2_HELPX

UniProt

H8H6L2 - H8H6L2_HELPX

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Protein
Isocitrate dehydrogenase [NADP]
Gene
HPELS_00125
Organism
Helicobacter pylori ELS37
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.UniRule annotation

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciHPYL1055527:GLEB-28-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
ORF Names:HPELS_00125Imported
OrganismiHelicobacter pylori ELS37Imported
Taxonomic identifieri1055527 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000007885: Chromosome

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8H6L2-1 [UniParc]FASTAAdd to Basket

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MAYNPKILQK PKEGEEITIK DNKLHVPNHP IIPFIEGDGI GSDITPAMIK    50
VVDSAVQKAY KGEKKIAWYE VFVGEKCYQK FKDHKELSPE EQWLLPDTIE 100
AINHYKVSIK GPLTTPIGEG FRSLNVALRQ KMDLYVCLRP VRWYGSPSPV 150
KEPQKVDMVI FRENSEDIYA GIEWQEGSAE AKKLIHFLQN ELKVKKIRFP 200
ESSGVGIKPI SKEGTERLVR KAIEYAIDND KPSVTFVHKG NIMKYTEGAF 250
MKWGYALAQK EFNAQVIDKG PWCSLKNPKT GKEIIIKDMI ADAFLQQILL 300
RPSEYSVIAT MNLNGDYVSD ALAAMVGGIG IAPGANLNDT VGMFEATHGT 350
APKYAGLDKV NPGSIILSAE MMLRHMGWVE AADLIVSAME KAIKSKKVTY 400
DFARLMDGAK EVKCSEFASV MIENM 425
Length:425
Mass (Da):47,478
Last modified:May 16, 2012 - v1
Checksum:i582BAE84B00CE74A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002953 Genomic DNA. Translation: AFF19613.1.
RefSeqiWP_000323974.1. NC_017063.1.
YP_005424189.1. NC_017063.1.

Genome annotation databases

EnsemblBacteriaiAFF19613; AFF19613; HPELS_00125.
GeneIDi12019295.
KEGGihpe:HPELS_00125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP002953 Genomic DNA. Translation: AFF19613.1 .
RefSeqi WP_000323974.1. NC_017063.1.
YP_005424189.1. NC_017063.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFF19613 ; AFF19613 ; HPELS_00125 .
GeneIDi 12019295.
KEGGi hpe:HPELS_00125.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci HPYL1055527:GLEB-28-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Bertoli M.T., Kersulyte D., Pascasio M.A., Berg D.E.
    Submitted (JUL-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ELS37Imported.

Entry informationi

Entry nameiH8H6L2_HELPX
AccessioniPrimary (citable) accession number: H8H6L2
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: September 3, 2014
This is version 12 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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