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Protein

Catalase

Gene

HPELS_02155

Organism
Helicobacter pylori ELS37
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

2 H2O2 = O2 + 2 H2O.UniRule annotation

Cofactori

hemeUniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei56 – 561UniRule annotation
Active sitei129 – 1291UniRule annotation
Metal bindingi339 – 3391Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

  1. catalase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. hydrogen peroxide catabolic process Source: UniProtKB-KW
  2. response to oxidative stress Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase, Peroxidase

Keywords - Biological processi

Hydrogen peroxideUniRule annotation

Keywords - Ligandi

HemeUniRule annotation, Iron, Metal-binding

Enzyme and pathway databases

BioCyciHPYL1055527:GLEB-423-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
CatalaseUniRule annotation (EC:1.11.1.6UniRule annotation)
Gene namesi
ORF Names:HPELS_02155Imported
OrganismiHelicobacter pylori ELS37Imported
Taxonomic identifieri1055527 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaEpsilonproteobacteriaCampylobacteralesHelicobacteraceaeHelicobacter
ProteomesiUP000007885 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the catalase family.UniRule annotation

Phylogenomic databases

KOiK03781.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8H424-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVNKDVKQTT AFGAPVWDDN NVITAGPRGP VLLQSTWFLE KLAAFDRERI
60 70 80 90 100
PERVVHAKGS GAYGTFTVTK DITKYTKAKI FSKVGKKTEC FFRFSTVAGE
110 120 130 140 150
KGSADAVRDP RGFAMKYYTE EGNWDLVGNN TPVFFIRDAI KFPDFIHTQK
160 170 180 190 200
RDPQTNLPNP DMVWDFWSNV PESLYQVTWV MSDRGIPKSF RHMDGFGSHT
210 220 230 240 250
FSLINAKGER FWVKFHFETM QGVKHLTNEE AAEIRKHDPD SNQRDLFNAI
260 270 280 290 300
ARGDFPKWKL SIQVMPEEDA KKYRFHPFDV TKIWYLKDYP LMEVGIVELN
310 320 330 340 350
KNPENYFAEV EQAAFTPANV VPGIGYSPDR MLQGRLFSYG DTHRYRLGVN
360 370 380 390 400
YAQIPVNKPR CPFHSSSRDG YMQNGYYGSL QNYTPSSLPG YKEDKSARDP
410 420 430 440 450
KFNLAHIEKE FEVWNWDYRA DDSDYYTQPG DYYRSLPADE KERLHDTIGE
460 470 480 490 500
SLAHVTHKEI VDKQLEHFKK ADPKYAEGVK KALEKHQKMM KDMHAKDMHH

TKKKK
Length:505
Mass (Da):58,543
Last modified:May 16, 2012 - v1
Checksum:iF9BDC3E8C900DB3E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002953 Genomic DNA. Translation: AFF19991.1.
RefSeqiYP_005424567.1. NC_017063.1.

Genome annotation databases

EnsemblBacteriaiAFF19991; AFF19991; HPELS_02155.
KEGGihpe:HPELS_02155.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002953 Genomic DNA. Translation: AFF19991.1.
RefSeqiYP_005424567.1. NC_017063.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFF19991; AFF19991; HPELS_02155.
KEGGihpe:HPELS_02155.

Phylogenomic databases

KOiK03781.

Enzyme and pathway databases

BioCyciHPYL1055527:GLEB-423-MONOMER.

Family and domain databases

Gene3Di2.40.180.10. 1 hit.
InterProiIPR018028. Catalase.
IPR020835. Catalase-like_dom.
IPR024708. Catalase_AS.
IPR024711. Catalase_clade1/3.
IPR011614. Catalase_core.
IPR002226. Catalase_haem_BS.
IPR010582. Catalase_immune_responsive.
[Graphical view]
PANTHERiPTHR11465. PTHR11465. 1 hit.
PfamiPF00199. Catalase. 1 hit.
PF06628. Catalase-rel. 1 hit.
[Graphical view]
PIRSFiPIRSF038928. Catalase_clade1-3. 1 hit.
PRINTSiPR00067. CATALASE.
SMARTiSM01060. Catalase. 1 hit.
[Graphical view]
SUPFAMiSSF56634. SSF56634. 1 hit.
PROSITEiPS00437. CATALASE_1. 1 hit.
PS00438. CATALASE_2. 1 hit.
PS51402. CATALASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Bertoli M.T., Kersulyte D., Pascasio M.A., Berg D.E.
    Submitted (JUN-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: ELS37Imported.

Entry informationi

Entry nameiH8H424_HELPX
AccessioniPrimary (citable) accession number: H8H424
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: April 1, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.