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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Deinococcus gobiensis (strain DSM 21396 / JCM 16679 / CGMCC 1.7299 / I-0)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Mg2+UniRule annotation, Mn2+UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciDGOB745776:GLCE-1740-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:DGo_CA1691Imported
OrganismiDeinococcus gobiensis (strain DSM 21396 / JCM 16679 / CGMCC 1.7299 / I-0)Imported
Taxonomic identifieri745776 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000007575 Componenti: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8GVQ6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSHIKVPAQ GEKITMQGDK LQVPAQPIIP FVEGDGTGRD IWKASVRVLD
60 70 80 90 100
AAVEAAYGNE RKIEWLEVYA GEKSTQVYGE NEWLPDETVK AFDEYLIGIK
110 120 130 140 150
GPLTTPVGGG IRSINVALRQ LLDLYACLRP VQYFAGVPSP LKQPELVDMV
160 170 180 190 200
IFRENTEDIY AGIEYKAGTA EANKLRDFLI NEMGVTQIRF PDSSSLGVKP
210 220 230 240 250
VSKEGTERLV RAAIQYAIDN GRKSVTLVHK GNIMKFTEGG FRDWGYDLAK
260 270 280 290 300
REFGGVELDG GPWLQLPNGI VIKDVIADAF LQQILLRPAE YDVIATLNLN
310 320 330 340 350
GDYVSDALAA QVGGIGIAPG ANINYVTGHA IFEATHGTAP KYADKNVINP
360 370 380 390 400
SSVILSGEMM LRHMGWTEAA DLILKGLDQT IGQKVVTYDF ARNMEGATEV
410
KTSEFADKII ENMKAMAQA
Length:419
Mass (Da):45,825
Last modified:May 16, 2012 - v1
Checksum:iB7395F9A856F0A7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002191 Genomic DNA. Translation: AFD25618.1.
RefSeqiWP_014685101.1. NC_017790.1.
YP_006261076.1. NC_017790.1.

Genome annotation databases

EnsemblBacteriaiAFD25618; AFD25618; DGo_CA1691.
KEGGidgo:DGo_CA1691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002191 Genomic DNA. Translation: AFD25618.1.
RefSeqiWP_014685101.1. NC_017790.1.
YP_006261076.1. NC_017790.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAFD25618; AFD25618; DGo_CA1691.
KEGGidgo:DGo_CA1691.

Phylogenomic databases

KOiK00031.

Enzyme and pathway databases

BioCyciDGOB745776:GLCE-1740-MONOMER.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence and transcriptome analysis of the radioresistant bacterium Deinococcus gobiensis: insights into the extreme environmental adaptations."
    Yuan M., Chen M., Zhang W., Lu W., Wang J., Yang M., Zhao P., Tang R., Li X., Hao Y., Zhou Z., Zhan Y., Yu H., Teng C., Yan Y., Ping S., Wang Y., Lin M.
    PLoS ONE 7:E34458-E34458(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 21396 / JCM 16679 / CGMCC 1.7299 / I-0Imported.

Entry informationi

Entry nameiH8GVQ6_DEIGI
AccessioniPrimary (citable) accession number: H8GVQ6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: May 27, 2015
This is version 20 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.