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H8GVQ6

- H8GVQ6_DEIGI

UniProt

H8GVQ6 - H8GVQ6_DEIGI

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Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Deinococcus gobiensis (strain DSM 21396 / JCM 16679 / CGMCC 1.7299 / I-0)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciDGOB745776:GLCE-1740-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Name:icdImported
Ordered Locus Names:DGo_CA1691Imported
OrganismiDeinococcus gobiensis (strain DSM 21396 / JCM 16679 / CGMCC 1.7299 / I-0)Imported
Taxonomic identifieri745776 [NCBI]
Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
ProteomesiUP000007575: Chromosome

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

KOiK00031.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8GVQ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSHIKVPAQ GEKITMQGDK LQVPAQPIIP FVEGDGTGRD IWKASVRVLD
60 70 80 90 100
AAVEAAYGNE RKIEWLEVYA GEKSTQVYGE NEWLPDETVK AFDEYLIGIK
110 120 130 140 150
GPLTTPVGGG IRSINVALRQ LLDLYACLRP VQYFAGVPSP LKQPELVDMV
160 170 180 190 200
IFRENTEDIY AGIEYKAGTA EANKLRDFLI NEMGVTQIRF PDSSSLGVKP
210 220 230 240 250
VSKEGTERLV RAAIQYAIDN GRKSVTLVHK GNIMKFTEGG FRDWGYDLAK
260 270 280 290 300
REFGGVELDG GPWLQLPNGI VIKDVIADAF LQQILLRPAE YDVIATLNLN
310 320 330 340 350
GDYVSDALAA QVGGIGIAPG ANINYVTGHA IFEATHGTAP KYADKNVINP
360 370 380 390 400
SSVILSGEMM LRHMGWTEAA DLILKGLDQT IGQKVVTYDF ARNMEGATEV
410
KTSEFADKII ENMKAMAQA
Length:419
Mass (Da):45,825
Last modified:May 16, 2012 - v1
Checksum:iB7395F9A856F0A7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002191 Genomic DNA. Translation: AFD25618.1.
RefSeqiWP_014685101.1. NC_017790.1.
YP_006261076.1. NC_017790.1.

Genome annotation databases

EnsemblBacteriaiAFD25618; AFD25618; DGo_CA1691.
GeneIDi12814413.
KEGGidgo:DGo_CA1691.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP002191 Genomic DNA. Translation: AFD25618.1 .
RefSeqi WP_014685101.1. NC_017790.1.
YP_006261076.1. NC_017790.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AFD25618 ; AFD25618 ; DGo_CA1691 .
GeneIDi 12814413.
KEGGi dgo:DGo_CA1691.

Phylogenomic databases

KOi K00031.

Enzyme and pathway databases

BioCyci DGOB745776:GLCE-1740-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence and transcriptome analysis of the radioresistant bacterium Deinococcus gobiensis: insights into the extreme environmental adaptations."
    Yuan M., Chen M., Zhang W., Lu W., Wang J., Yang M., Zhao P., Tang R., Li X., Hao Y., Zhou Z., Zhan Y., Yu H., Teng C., Yan Y., Ping S., Wang Y., Lin M.
    PLoS ONE 7:E34458-E34458(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 21396 / JCM 16679 / CGMCC 1.7299 / I-0Imported.

Entry informationi

Entry nameiH8GVQ6_DEIGI
AccessioniPrimary (citable) accession number: H8GVQ6
Entry historyi
Integrated into UniProtKB/TrEMBL: May 16, 2012
Last sequence update: May 16, 2012
Last modified: November 26, 2014
This is version 15 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3