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H8GVQ6

- H8GVQ6_DEIGI

UniProt

H8GVQ6 - H8GVQ6_DEIGI

Protein

Isocitrate dehydrogenase [NADP]

Gene

icd

Organism
Deinococcus gobiensis (strain DSM 21396 / JCM 16679 / CGMCC 1.7299 / I-0)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 13 (01 Oct 2014)
      Sequence version 1 (16 May 2012)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

    Cofactori

    Binds 1 magnesium or manganese ion per subunit.UniRule annotation

    GO - Molecular functioni

    1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
    2. magnesium ion binding Source: InterPro
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. glyoxylate cycle Source: UniProtKB-KW
    2. tricarboxylic acid cycle Source: UniProtKB-KW

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotation

    Keywords - Biological processi

    Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

    Keywords - Ligandi

    ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

    Enzyme and pathway databases

    BioCyciDGOB745776:GLCE-1740-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
    Gene namesi
    Name:icdImported
    Ordered Locus Names:DGo_CA1691Imported
    OrganismiDeinococcus gobiensis (strain DSM 21396 / JCM 16679 / CGMCC 1.7299 / I-0)Imported
    Taxonomic identifieri745776 [NCBI]
    Taxonomic lineageiBacteriaDeinococcus-ThermusDeinococciDeinococcalesDeinococcaceaeDeinococcus
    ProteomesiUP000007575: Chromosome

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

    Phylogenomic databases

    KOiK00031.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view]
    PANTHERiPTHR11835. PTHR11835. 1 hit.
    PfamiPF00180. Iso_dh. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
    PROSITEiPS00470. IDH_IMDH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H8GVQ6-1 [UniParc]FASTAAdd to Basket

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    MTSHIKVPAQ GEKITMQGDK LQVPAQPIIP FVEGDGTGRD IWKASVRVLD    50
    AAVEAAYGNE RKIEWLEVYA GEKSTQVYGE NEWLPDETVK AFDEYLIGIK 100
    GPLTTPVGGG IRSINVALRQ LLDLYACLRP VQYFAGVPSP LKQPELVDMV 150
    IFRENTEDIY AGIEYKAGTA EANKLRDFLI NEMGVTQIRF PDSSSLGVKP 200
    VSKEGTERLV RAAIQYAIDN GRKSVTLVHK GNIMKFTEGG FRDWGYDLAK 250
    REFGGVELDG GPWLQLPNGI VIKDVIADAF LQQILLRPAE YDVIATLNLN 300
    GDYVSDALAA QVGGIGIAPG ANINYVTGHA IFEATHGTAP KYADKNVINP 350
    SSVILSGEMM LRHMGWTEAA DLILKGLDQT IGQKVVTYDF ARNMEGATEV 400
    KTSEFADKII ENMKAMAQA 419
    Length:419
    Mass (Da):45,825
    Last modified:May 16, 2012 - v1
    Checksum:iB7395F9A856F0A7A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002191 Genomic DNA. Translation: AFD25618.1.
    RefSeqiYP_006261076.1. NC_017790.1.

    Genome annotation databases

    EnsemblBacteriaiAFD25618; AFD25618; DGo_CA1691.
    GeneIDi12814413.
    KEGGidgo:DGo_CA1691.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP002191 Genomic DNA. Translation: AFD25618.1 .
    RefSeqi YP_006261076.1. NC_017790.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AFD25618 ; AFD25618 ; DGo_CA1691 .
    GeneIDi 12814413.
    KEGGi dgo:DGo_CA1691.

    Phylogenomic databases

    KOi K00031.

    Enzyme and pathway databases

    BioCyci DGOB745776:GLCE-1740-MONOMER.

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
    IPR001804. Isocitrate/isopropylmalate_DH.
    IPR004439. Isocitrate_DH_NADP_dimer_prok.
    IPR024084. IsoPropMal-DH-like_dom.
    [Graphical view ]
    PANTHERi PTHR11835. PTHR11835. 1 hit.
    Pfami PF00180. Iso_dh. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
    PROSITEi PS00470. IDH_IMDH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence and transcriptome analysis of the radioresistant bacterium Deinococcus gobiensis: insights into the extreme environmental adaptations."
      Yuan M., Chen M., Zhang W., Lu W., Wang J., Yang M., Zhao P., Tang R., Li X., Hao Y., Zhou Z., Zhan Y., Yu H., Teng C., Yan Y., Ping S., Wang Y., Lin M.
      PLoS ONE 7:E34458-E34458(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 21396 / JCM 16679 / CGMCC 1.7299 / I-0Imported.

    Entry informationi

    Entry nameiH8GVQ6_DEIGI
    AccessioniPrimary (citable) accession number: H8GVQ6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 16, 2012
    Last sequence update: May 16, 2012
    Last modified: October 1, 2014
    This is version 13 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3