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H8F1Z2

- BFRB_MYCTE

UniProt

H8F1Z2 - BFRB_MYCTE

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Protein

Ferritin BfrB

Gene

bfrB

Organism
Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe2+ ions into Fe3+ ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex.By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi22 – 221Iron 1PROSITE-ProRule annotation
Metal bindingi55 – 551Iron 1PROSITE-ProRule annotation
Metal bindingi55 – 551Iron 2PROSITE-ProRule annotation
Metal bindingi58 – 581Iron 1PROSITE-ProRule annotation
Metal bindingi99 – 991Iron 2PROSITE-ProRule annotation
Metal bindingi132 – 1321Iron 2PROSITE-ProRule annotation

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin BfrB (EC:1.16.3.1)
Alternative name(s):
Bacterioferritin
Non-heme ferritin Ftn
Nox19
Gene namesi
Name:bfrB
Ordered Locus Names:ERDMAN_4208
OrganismiMycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Taxonomic identifieri652616 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000007568: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Ferritin BfrBPRO_0000422687Add
BLAST

Expressioni

Inductioni

Repressed by Rip1, highly induced by metal chelator phenanthroline in the absence of Rip1.1 Publication

Interactioni

Subunit structurei

Homooligomer of 24 subunits that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be stored.By similarity

Structurei

3D structure databases

ProteinModelPortaliH8F1Z2.
SMRiH8F1Z2. Positions 8-181.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 150136Ferritin-like diironPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ferritin family. Prokaryotic subfamily.Curated
Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8F1Z2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTEYEGPKTK FHALMQEQIH NEFTAAQQYV AIAVYFDSED LPQLAKHFYS
60 70 80 90 100
QAVEERNHAM MLVQHLLDRD LRVEIPGVDT VRNQFDRPRE ALALALDQER
110 120 130 140 150
TVTDQVGRLT AVARDEGDFL GEQFMQWFLQ EQIEEVALMA TLVRVADRAG
160 170 180
ANLFELENFV AREVDVAPAA SGAPHAAGGR L
Length:181
Mass (Da):20,442
Last modified:June 26, 2013 - v2
Checksum:iC0F375669A292F55
GO

Sequence cautioni

The sequence BAL67972.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012340 Genomic DNA. Translation: BAL67972.1. Different initiation.
RefSeqiYP_007612649.1. NC_020559.1.

Genome annotation databases

EnsemblBacteriaiBAL67972; BAL67972; ERDMAN_4208.
GeneIDi14963012.
KEGGimtn:ERDMAN_4208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AP012340 Genomic DNA. Translation: BAL67972.1 . Different initiation.
RefSeqi YP_007612649.1. NC_020559.1.

3D structure databases

ProteinModelPortali H8F1Z2.
SMRi H8F1Z2. Positions 8-181.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAL67972 ; BAL67972 ; ERDMAN_4208 .
GeneIDi 14963012.
KEGGi mtn:ERDMAN_4208.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete annotated genome sequence of Mycobacterium tuberculosis Erdman."
    Miyoshi-Akiyama T., Matsumura K., Iwai H., Funatogawa K., Kirikae T.
    J. Bacteriol. 194:2770-2770(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35801 / TMC 107 / Erdman.
  2. "M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates."
    Sklar J.G., Makinoshima H., Schneider J.S., Glickman M.S.
    Mol. Microbiol. 77:605-617(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: ATCC 35801 / TMC 107 / Erdman.

Entry informationi

Entry nameiBFRB_MYCTE
AccessioniPrimary (citable) accession number: H8F1Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: June 26, 2013
Last modified: October 1, 2014
This is version 16 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3