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H8F1Z2 (BFRB_MYCTE) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 14. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ferritin BfrB

EC=1.16.3.1
Alternative name(s):
Bacterioferritin
Non-heme ferritin Ftn
Nox19
Gene names
Name:bfrB
Ordered Locus Names:ERDMAN_4208
OrganismMycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman) [Complete proteome] [HAMAP]
Taxonomic identifier652616 [NCBI]
Taxonomic lineageBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex

Protein attributes

Sequence length181 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe2+ ions into Fe3+ ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex By similarity.

Catalytic activity

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Subunit structure

Homooligomer of 24 subunits that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be stored By similarity.

Induction

Repressed by Rip1, highly induced by metal chelator phenanthroline in the absence of Rip1. Ref.2

Sequence similarities

Belongs to the ferritin family. Prokaryotic subfamily.

Contains 1 ferritin-like diiron domain.

Sequence caution

The sequence BAL67972.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Biological processIron storage
   LigandIron
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcellular iron ion homeostasis

Inferred from electronic annotation. Source: UniProtKB-KW

iron ion transport

Inferred from electronic annotation. Source: InterPro

   Molecular_functionferric iron binding

Inferred from electronic annotation. Source: InterPro

ferroxidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 181181Ferritin BfrB
PRO_0000422687

Regions

Domain15 – 150136Ferritin-like diiron

Sites

Metal binding221Iron 1 By similarity
Metal binding551Iron 1 By similarity
Metal binding551Iron 2 By similarity
Metal binding581Iron 1 By similarity
Metal binding991Iron 2 By similarity
Metal binding1321Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
H8F1Z2 [UniParc].

Last modified June 26, 2013. Version 2.
Checksum: C0F375669A292F55

FASTA18120,442
        10         20         30         40         50         60 
MTEYEGPKTK FHALMQEQIH NEFTAAQQYV AIAVYFDSED LPQLAKHFYS QAVEERNHAM 

        70         80         90        100        110        120 
MLVQHLLDRD LRVEIPGVDT VRNQFDRPRE ALALALDQER TVTDQVGRLT AVARDEGDFL 

       130        140        150        160        170        180 
GEQFMQWFLQ EQIEEVALMA TLVRVADRAG ANLFELENFV AREVDVAPAA SGAPHAAGGR 


L 

« Hide

References

« Hide 'large scale' references
[1]"Complete annotated genome sequence of Mycobacterium tuberculosis Erdman."
Miyoshi-Akiyama T., Matsumura K., Iwai H., Funatogawa K., Kirikae T.
J. Bacteriol. 194:2770-2770(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 35801 / TMC 107 / Erdman.
[2]"M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates."
Sklar J.G., Makinoshima H., Schneider J.S., Glickman M.S.
Mol. Microbiol. 77:605-617(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION.
Strain: ATCC 35801 / TMC 107 / Erdman.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AP012340 Genomic DNA. Translation: BAL67972.1. Different initiation.
RefSeqYP_007612649.1. NC_020559.1.

3D structure databases

ProteinModelPortalH8F1Z2.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAL67972; BAL67972; ERDMAN_4208.
GeneID14963012.
KEGGmtn:ERDMAN_4208.

Organism-specific databases

CMRSearch...

Family and domain databases

Gene3D1.20.1260.10. 1 hit.
InterProIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERPTHR11431. PTHR11431. 1 hit.
PfamPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBFRB_MYCTE
AccessionPrimary (citable) accession number: H8F1Z2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: June 26, 2013
Last modified: March 19, 2014
This is version 14 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families