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H8F1Z2

- BFRB_MYCTE

UniProt

H8F1Z2 - BFRB_MYCTE

Protein

Ferritin BfrB

Gene

bfrB

Organism
Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 16 (01 Oct 2014)
      Sequence version 2 (26 Jun 2013)
      Previous versions | rss
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    Functioni

    Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe2+ ions into Fe3+ ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex.By similarity

    Catalytic activityi

    4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi22 – 221Iron 1PROSITE-ProRule annotation
    Metal bindingi55 – 551Iron 1PROSITE-ProRule annotation
    Metal bindingi55 – 551Iron 2PROSITE-ProRule annotation
    Metal bindingi58 – 581Iron 1PROSITE-ProRule annotation
    Metal bindingi99 – 991Iron 2PROSITE-ProRule annotation
    Metal bindingi132 – 1321Iron 2PROSITE-ProRule annotation

    GO - Molecular functioni

    1. ferric iron binding Source: InterPro
    2. ferroxidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular iron ion homeostasis Source: UniProtKB-KW
    2. iron ion transport Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Iron storage

    Keywords - Ligandi

    Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ferritin BfrB (EC:1.16.3.1)
    Alternative name(s):
    Bacterioferritin
    Non-heme ferritin Ftn
    Nox19
    Gene namesi
    Name:bfrB
    Ordered Locus Names:ERDMAN_4208
    OrganismiMycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
    Taxonomic identifieri652616 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
    ProteomesiUP000007568: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 181181Ferritin BfrBPRO_0000422687Add
    BLAST

    Expressioni

    Inductioni

    Repressed by Rip1, highly induced by metal chelator phenanthroline in the absence of Rip1.1 Publication

    Interactioni

    Subunit structurei

    Homooligomer of 24 subunits that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be stored.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliH8F1Z2.
    SMRiH8F1Z2. Positions 8-181.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 150136Ferritin-like diironPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ferritin family. Prokaryotic subfamily.Curated
    Contains 1 ferritin-like diiron domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di1.20.1260.10. 1 hit.
    InterProiIPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view]
    PANTHERiPTHR11431. PTHR11431. 1 hit.
    PfamiPF00210. Ferritin. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    H8F1Z2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTEYEGPKTK FHALMQEQIH NEFTAAQQYV AIAVYFDSED LPQLAKHFYS    50
    QAVEERNHAM MLVQHLLDRD LRVEIPGVDT VRNQFDRPRE ALALALDQER 100
    TVTDQVGRLT AVARDEGDFL GEQFMQWFLQ EQIEEVALMA TLVRVADRAG 150
    ANLFELENFV AREVDVAPAA SGAPHAAGGR L 181
    Length:181
    Mass (Da):20,442
    Last modified:June 26, 2013 - v2
    Checksum:iC0F375669A292F55
    GO

    Sequence cautioni

    The sequence BAL67972.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012340 Genomic DNA. Translation: BAL67972.1. Different initiation.
    RefSeqiYP_007612649.1. NC_020559.1.

    Genome annotation databases

    EnsemblBacteriaiBAL67972; BAL67972; ERDMAN_4208.
    GeneIDi14963012.
    KEGGimtn:ERDMAN_4208.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AP012340 Genomic DNA. Translation: BAL67972.1 . Different initiation.
    RefSeqi YP_007612649.1. NC_020559.1.

    3D structure databases

    ProteinModelPortali H8F1Z2.
    SMRi H8F1Z2. Positions 8-181.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAL67972 ; BAL67972 ; ERDMAN_4208 .
    GeneIDi 14963012.
    KEGGi mtn:ERDMAN_4208.

    Family and domain databases

    Gene3Di 1.20.1260.10. 1 hit.
    InterProi IPR001519. Ferritin.
    IPR009040. Ferritin-like_diiron.
    IPR009078. Ferritin-like_SF.
    IPR012347. Ferritin-rel.
    IPR008331. Ferritin_DPS_dom.
    [Graphical view ]
    PANTHERi PTHR11431. PTHR11431. 1 hit.
    Pfami PF00210. Ferritin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete annotated genome sequence of Mycobacterium tuberculosis Erdman."
      Miyoshi-Akiyama T., Matsumura K., Iwai H., Funatogawa K., Kirikae T.
      J. Bacteriol. 194:2770-2770(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 35801 / TMC 107 / Erdman.
    2. "M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates."
      Sklar J.G., Makinoshima H., Schneider J.S., Glickman M.S.
      Mol. Microbiol. 77:605-617(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION.
      Strain: ATCC 35801 / TMC 107 / Erdman.

    Entry informationi

    Entry nameiBFRB_MYCTE
    AccessioniPrimary (citable) accession number: H8F1Z2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2013
    Last sequence update: June 26, 2013
    Last modified: October 1, 2014
    This is version 16 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3