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H8F1Z2

- BFRB_MYCTE

UniProt

H8F1Z2 - BFRB_MYCTE

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Protein
Ferritin BfrB
Gene
bfrB, ERDMAN_4208
Organism
Mycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Iron-storage protein that displays ferroxidase activity, catalyzing the oxidation of Fe2+ ions into Fe3+ ions, that can then be deposited as a ferric-oxide mineral core within the central cavity of the protein complex By similarity.

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi22 – 221Iron 1 By similarity
Metal bindingi55 – 551Iron 1 By similarity
Metal bindingi55 – 551Iron 2 By similarity
Metal bindingi58 – 581Iron 1 By similarity
Metal bindingi99 – 991Iron 2 By similarity
Metal bindingi132 – 1321Iron 2 By similarity

GO - Molecular functioni

  1. ferric iron binding Source: InterPro
  2. ferroxidase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. cellular iron ion homeostasis Source: UniProtKB-KW
  2. iron ion transport Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Iron storage

Keywords - Ligandi

Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin BfrB (EC:1.16.3.1)
Alternative name(s):
Bacterioferritin
Non-heme ferritin Ftn
Nox19
Gene namesi
Name:bfrB
Ordered Locus Names:ERDMAN_4208
OrganismiMycobacterium tuberculosis (strain ATCC 35801 / TMC 107 / Erdman)
Taxonomic identifieri652616 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeActinomycetalesCorynebacterineaeMycobacteriaceaeMycobacteriumMycobacterium tuberculosis complex
ProteomesiUP000007568: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 181181Ferritin BfrB
PRO_0000422687Add
BLAST

Expressioni

Inductioni

Repressed by Rip1, highly induced by metal chelator phenanthroline in the absence of Rip1.1 Publication

Interactioni

Subunit structurei

Homooligomer of 24 subunits that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be stored By similarity.

Structurei

3D structure databases

ProteinModelPortaliH8F1Z2.
SMRiH8F1Z2. Positions 8-181.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 150136Ferritin-like diiron
Add
BLAST

Sequence similaritiesi

Family and domain databases

Gene3Di1.20.1260.10. 1 hit.
InterProiIPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view]
PANTHERiPTHR11431. PTHR11431. 1 hit.
PfamiPF00210. Ferritin. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS50905. FERRITIN_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H8F1Z2-1 [UniParc]FASTAAdd to Basket

« Hide

MTEYEGPKTK FHALMQEQIH NEFTAAQQYV AIAVYFDSED LPQLAKHFYS    50
QAVEERNHAM MLVQHLLDRD LRVEIPGVDT VRNQFDRPRE ALALALDQER 100
TVTDQVGRLT AVARDEGDFL GEQFMQWFLQ EQIEEVALMA TLVRVADRAG 150
ANLFELENFV AREVDVAPAA SGAPHAAGGR L 181
Length:181
Mass (Da):20,442
Last modified:June 26, 2013 - v2
Checksum:iC0F375669A292F55
GO

Sequence cautioni

The sequence BAL67972.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012340 Genomic DNA. Translation: BAL67972.1. Different initiation.
RefSeqiYP_007612649.1. NC_020559.1.

Genome annotation databases

EnsemblBacteriaiBAL67972; BAL67972; ERDMAN_4208.
GeneIDi14963012.
KEGGimtn:ERDMAN_4208.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AP012340 Genomic DNA. Translation: BAL67972.1 . Different initiation.
RefSeqi YP_007612649.1. NC_020559.1.

3D structure databases

ProteinModelPortali H8F1Z2.
SMRi H8F1Z2. Positions 8-181.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAL67972 ; BAL67972 ; ERDMAN_4208 .
GeneIDi 14963012.
KEGGi mtn:ERDMAN_4208.

Family and domain databases

Gene3Di 1.20.1260.10. 1 hit.
InterProi IPR001519. Ferritin.
IPR009040. Ferritin-like_diiron.
IPR009078. Ferritin-like_SF.
IPR012347. Ferritin-rel.
IPR008331. Ferritin_DPS_dom.
[Graphical view ]
PANTHERi PTHR11431. PTHR11431. 1 hit.
Pfami PF00210. Ferritin. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS50905. FERRITIN_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete annotated genome sequence of Mycobacterium tuberculosis Erdman."
    Miyoshi-Akiyama T., Matsumura K., Iwai H., Funatogawa K., Kirikae T.
    J. Bacteriol. 194:2770-2770(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 35801 / TMC 107 / Erdman.
  2. "M. tuberculosis intramembrane protease Rip1 controls transcription through three anti-sigma factor substrates."
    Sklar J.G., Makinoshima H., Schneider J.S., Glickman M.S.
    Mol. Microbiol. 77:605-617(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION.
    Strain: ATCC 35801 / TMC 107 / Erdman.

Entry informationi

Entry nameiBFRB_MYCTE
AccessioniPrimary (citable) accession number: H8F1Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2013
Last sequence update: June 26, 2013
Last modified: June 11, 2014
This is version 15 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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