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Protein
Submitted name:

DNA topoisomerase IV, B subunit

Gene

parE

Organism
Enterococcus faecalis (strain ATCC 700802 / V583)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

IsomeraseImported

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-1599-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
DNA topoisomerase IV, B subunitImported
Gene namesi
Name:parEImported
Ordered Locus Names:EF_1615Imported
OrganismiEnterococcus faecalis (strain ATCC 700802 / V583)Imported
Taxonomic identifieri226185 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesEnterococcaceaeEnterococcus
ProteomesiUP000001415 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HZ5X-ray2.70A/B/C/D/E/F/G/H/J19-225[»]
ProteinModelPortaliH7C794.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

KOiK02622.
OMAiHESGKPT.
OrthoDBiEOG6P334W.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
3.40.50.670. 1 hit.
HAMAPiMF_00939. ParE_type2.
InterProiIPR002288. DNA_gyrase_B_C.
IPR003594. HATPase_C.
IPR005740. ParE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013506. Topo_IIA_bsu_dom2.
IPR013759. Topo_IIA_cen_dom.
IPR013760. Topo_IIA_like_dom.
IPR018522. TopoIIA_CS.
IPR006171. Toprim_domain.
[Graphical view]
PfamiPF00204. DNA_gyraseB. 1 hit.
PF00986. DNA_gyraseB_C. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
[Graphical view]
PRINTSiPR00418. TPI2FAMILY.
SMARTiSM00387. HATPase_c. 1 hit.
SM00433. TOP2c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01058. parE_Gpos. 1 hit.
PROSITEiPS00177. TOPOISOMERASE_II. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

H7C794-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKKINNEYN DASIQVLEGL EAVRKRPGMY IGSTDSRGLH HLVYEIVDNA
60 70 80 90 100
VDEALSGYGN EINVTIQKDN SICVADSGRG MPTGMHASGI PTVEVIFTVL
110 120 130 140 150
HAGGKFGQGG YKTSGGLHGV GASVVNALSK WLEVHIVRDG VEYMERFEDG
160 170 180 190 200
GKPVGTLKKI GKTKKRNGTS VTFLPDDTIF STTNFSYEIL AERLRESAFL
210 220 230 240 250
LKGVKITLTD ERGEEPKEEV FHYEEGIKEF VAYLNEEKDT LTPVVYFSGA
260 270 280 290 300
KEGIEVELAY QYNDGYSENV LSFVNNVRTK DGGTHEVGMK TSMTKAYNEY
310 320 330 340 350
ARKVGLLKEK DKNLEGSDFR EGLAAVLSIR VPENLLQFEG QTKGKLGTPL
360 370 380 390 400
ARTVVDNVVG EQMGFYLQEN SEMSQSLIRK AIKAREAREA ARKAREESRN
410 420 430 440 450
GKKRKKGESL LSGKLTPAQS RNPKKNELYL VEGDSAGGSA KQGRDRKFQA
460 470 480 490 500
ILPLRGKVIN TEKAKMQDIL KNEEINTMIY TIGAGVGPEF SIEDCNYDKI
510 520 530 540 550
IIMTDADTDG AHIQVLLLTF FYRYMKPLIE AGKVYIALPP LYKVSKGTGK
560 570 580 590 600
KSVIEYAWTD GELAEVIDKV GKGYMLQRYK GLGEMNAEQL WETTMDPETR
610 620 630 640 650
TLIRVRIDDA AQAERRVTTL MGDKVEPRRK WIEQHVQFTL EEDGSILDRS
660 670 680
EEDTSAPTGE SLLDAEKTKE AEQTDDTEIS LFDIE
Length:685
Mass (Da):76,257
Last modified:April 18, 2012 - v1
Checksum:iA4C79A5FB0915BFA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO81398.1.
RefSeqiNP_815328.1. NC_004668.1.
WP_002381887.1. NZ_KE136528.1.

Genome annotation databases

EnsemblBacteriaiAAO81398; AAO81398; EF_1615.
EOT50099; EOT50099; OO5_01863.
EOT84825; EOT84825; I574_02005.
GeneIDi1200513.
KEGGiefa:EF1615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE016830 Genomic DNA. Translation: AAO81398.1.
RefSeqiNP_815328.1. NC_004668.1.
WP_002381887.1. NZ_KE136528.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HZ5X-ray2.70A/B/C/D/E/F/G/H/J19-225[»]
ProteinModelPortaliH7C794.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAO81398; AAO81398; EF_1615.
EOT50099; EOT50099; OO5_01863.
EOT84825; EOT84825; I574_02005.
GeneIDi1200513.
KEGGiefa:EF1615.

Phylogenomic databases

KOiK02622.
OMAiHESGKPT.
OrthoDBiEOG6P334W.

Enzyme and pathway databases

BioCyciEFAE226185:GHI1-1599-MONOMER.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.565.10. 1 hit.
3.40.50.670. 1 hit.
HAMAPiMF_00939. ParE_type2.
InterProiIPR002288. DNA_gyrase_B_C.
IPR003594. HATPase_C.
IPR005740. ParE.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
IPR001241. Topo_IIA.
IPR013506. Topo_IIA_bsu_dom2.
IPR013759. Topo_IIA_cen_dom.
IPR013760. Topo_IIA_like_dom.
IPR018522. TopoIIA_CS.
IPR006171. Toprim_domain.
[Graphical view]
PfamiPF00204. DNA_gyraseB. 1 hit.
PF00986. DNA_gyraseB_C. 1 hit.
PF02518. HATPase_c. 1 hit.
PF01751. Toprim. 1 hit.
[Graphical view]
PRINTSiPR00418. TPI2FAMILY.
SMARTiSM00387. HATPase_c. 1 hit.
SM00433. TOP2c. 1 hit.
[Graphical view]
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55874. SSF55874. 1 hit.
SSF56719. SSF56719. 1 hit.
TIGRFAMsiTIGR01058. parE_Gpos. 1 hit.
PROSITEiPS00177. TOPOISOMERASE_II. 1 hit.
PS50880. TOPRIM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 700802 / V583Imported.
  2. "Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity."
    Tari L.W., Trzoss M., Bensen D.C., Li X., Chen Z., Lam T., Zhang J., Creighton C.J., Cunningham M.L., Kwan B., Stidham M., Shaw K.J., Lightstone F.C., Wong S.E., Nguyen T.B., Nix J., Finn J.
    Bioorg. Med. Chem. Lett. 23:1529-1536(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 19-225.

Entry informationi

Entry nameiH7C794_ENTFA
AccessioniPrimary (citable) accession number: H7C794
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: May 27, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.