ID   H7C5W3_HUMAN            Unreviewed;        84 AA.
AC   H7C5W3;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   RecName: Full=Stress-associated endoplasmic reticulum protein {ECO:0000256|RuleBase:RU364120};
GN   Name=SERP2 {ECO:0000313|Ensembl:ENSP00000435473.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000435473.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000435473.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057823; DOI=10.1038/nature02379;
RA   Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA   Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA   Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA   Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA   Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA   Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA   Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA   Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA   Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA   Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA   Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA   Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA   Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA   Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA   Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA   Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA   Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA   Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA   Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA   Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA   Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA   Coulson A., Durbin R., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA   Rogers J., Ross M.T.;
RT   "The DNA sequence and analysis of human chromosome 13.";
RL   Nature 428:522-528(2004).
RN   [2] {ECO:0000313|Ensembl:ENSP00000435473.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Interacts with target proteins during their translocation
CC       into the lumen of the endoplasmic reticulum. Protects unfolded target
CC       proteins against degradation during ER stress. May facilitate
CC       glycosylation of target proteins after termination of ER stress. May
CC       modulate the use of N-glycosylation sites on target proteins.
CC       {ECO:0000256|ARBA:ARBA00037157}.
CC   -!- FUNCTION: Interacts with target proteins during translocation into the
CC       lumen of the endoplasmic reticulum. Protects unfolded target proteins
CC       against degradation and facilitate correct glycosylation.
CC       {ECO:0000256|RuleBase:RU364120}.
CC   -!- SUBUNIT: Interacts with SEC61B, SEC61A1 and the SEC61 complex.
CC       Interacts with CANX. {ECO:0000256|ARBA:ARBA00038831}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU364120}; Single-
CC       pass membrane protein {ECO:0000256|RuleBase:RU364120}. Endoplasmic
CC       reticulum membrane {ECO:0000256|RuleBase:RU364120}; Single-pass
CC       membrane protein {ECO:0000256|RuleBase:RU364120}.
CC   -!- SIMILARITY: Belongs to the RAMP4 family.
CC       {ECO:0000256|ARBA:ARBA00005500, ECO:0000256|RuleBase:RU364120}.
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DR   EMBL; AL138960; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H7C5W3; -.
DR   MassIVE; H7C5W3; -.
DR   PeptideAtlas; H7C5W3; -.
DR   ProteomicsDB; 46154; -.
DR   Ensembl; ENST00000493476.1; ENSP00000435473.1; ENSG00000151778.11.
DR   UCSC; uc058wsu.1; human.
DR   HGNC; HGNC:20607; SERP2.
DR   VEuPathDB; HostDB:ENSG00000151778; -.
DR   GeneTree; ENSGT00940000162467; -.
DR   HOGENOM; CLU_160944_3_1_1; -.
DR   PhylomeDB; H7C5W3; -.
DR   ChiTaRS; SERP2; human.
DR   Proteomes; UP000005640; Chromosome 13.
DR   Bgee; ENSG00000151778; Expressed in Brodmann (1909) area 9 and 130 other cell types or tissues.
DR   ExpressionAtlas; H7C5W3; baseline and differential.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   InterPro; IPR010580; ER_stress-assoc.
DR   PANTHER; PTHR15601; STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4; 1.
DR   PANTHER; PTHR15601:SF20; STRESS-ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN 2; 1.
DR   Pfam; PF06624; RAMP4; 1.
PE   1: Evidence at protein level;
KW   Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW   ECO:0000256|RuleBase:RU364120}; Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Proteomics identification {ECO:0007829|ProteomicsDB:H7C5W3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Unfolded protein response {ECO:0000256|ARBA:ARBA00023230}.
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   84 AA;  9283 MW;  C6BFB210AF006A33 CRC64;
     MVAKQRIRMA NEKHSKNITQ RGNVAKTLRP QEEKYPVGPW LLALFVFVVC GSGQPHKLAS
     PGDCQNFLKV VTSRGSHPTP KTGN
//