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Protein

DNA topoisomerase

Gene

TOP3B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.UniRule annotation

Catalytic activityi

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, TopoisomeraseUniRule annotation

Keywords - Ligandi

DNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomeraseUniRule annotation (EC:5.99.1.2UniRule annotation)
Gene namesi
Name:TOP3BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:11993. TOP3B.

PTM / Processingi

Proteomic databases

PaxDbiH7C4B0.
PeptideAtlasiH7C4B0.

Expressioni

Gene expression databases

BgeeiENSG00000100038.
ExpressionAtlasiH7C4B0. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000349705.

Structurei

3D structure databases

ProteinModelPortaliH7C4B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 168148TOP1AcInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the type IA topoisomerase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1956. Eukaryota.
COG0550. LUCA.
GeneTreeiENSGT00530000063430.

Family and domain databases

Gene3Di1.10.290.10. 1 hit.
InterProiIPR000380. Topo_IA.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR013826. Topo_IA_cen_sub3.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11390. PTHR11390. 1 hit.
PfamiPF01131. Topoisom_bac. 1 hit.
[Graphical view]
SMARTiSM00437. TOP1Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56712. SSF56712. 1 hit.
PROSITEiPS00396. TOPOISOMERASE_I_PROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

H7C4B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IAQMFLNMTK LEKEAQVEAT SRKEKAKQRP LALNTVEMLR VASSSLGMGP
60 70 80 90 100
QHAMQTAERL YTQGYISYPR TETTHYPENF DLKGSLRQQA NHPYWADTVK
110 120 130 140 150
RLLAEGINRP RKGHDAGDHP PITPMKSATE AELGFAVCPA QRLCKQELAA
160
RARVLGAPHG QSPQLAPN
Length:168
Mass (Da):18,658
Last modified:April 18, 2012 - v1
Checksum:i22488C1D712B94FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245452 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000436282; ENSP00000416451; ENSG00000100038.
UCSCiuc062cao.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245452 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliH7C4B0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000349705.

Proteomic databases

PaxDbiH7C4B0.
PeptideAtlasiH7C4B0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000436282; ENSP00000416451; ENSG00000100038.
UCSCiuc062cao.1. human.

Organism-specific databases

HGNCiHGNC:11993. TOP3B.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1956. Eukaryota.
COG0550. LUCA.
GeneTreeiENSGT00530000063430.

Gene expression databases

BgeeiENSG00000100038.
ExpressionAtlasiH7C4B0. baseline and differential.

Family and domain databases

Gene3Di1.10.290.10. 1 hit.
InterProiIPR000380. Topo_IA.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR013826. Topo_IA_cen_sub3.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
[Graphical view]
PANTHERiPTHR11390. PTHR11390. 1 hit.
PfamiPF01131. Topoisom_bac. 1 hit.
[Graphical view]
SMARTiSM00437. TOP1Ac. 1 hit.
[Graphical view]
SUPFAMiSSF56712. SSF56712. 1 hit.
PROSITEiPS00396. TOPOISOMERASE_I_PROK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiH7C4B0_HUMAN
AccessioniPrimary (citable) accession number: H7C4B0
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 7, 2016
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.