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Protein

DNA topoisomerase

Gene

TOP3B

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.UniRule annotation

Catalytic activityi

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingUniRule annotation, Isomerase, TopoisomeraseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomeraseUniRule annotation (EC:5.99.1.2UniRule annotation)
Gene namesi
Name:TOP3BImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

EuPathDBiHostDB:ENSG00000100038.19.
HGNCiHGNC:11993. TOP3B.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100038.

PTM / Processingi

Proteomic databases

MaxQBiH7C4B0.
PaxDbiH7C4B0.
PeptideAtlasiH7C4B0.
PRIDEiH7C4B0.

Expressioni

Gene expression databases

BgeeiENSG00000100038.
ExpressionAtlasiH7C4B0. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH7C4B0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 168TOP1AcInterPro annotationAdd BLAST148

Sequence similaritiesi

Belongs to the type IA topoisomerase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG1956. Eukaryota.
COG0550. LUCA.
GeneTreeiENSGT00530000063430.

Family and domain databases

InterProiView protein in InterPro
IPR000380. Topo_IA.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
PANTHERiPTHR11390. PTHR11390. 1 hit.
PfamiView protein in Pfam
PF01131. Topoisom_bac. 1 hit.
SMARTiView protein in SMART
SM00437. TOP1Ac. 1 hit.
SUPFAMiSSF56712. SSF56712. 1 hit.
PROSITEiView protein in PROSITE
PS00396. TOPOISOMERASE_I_PROK. 1 hit.

Sequencei

Sequence statusi: Fragment.

H7C4B0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
IAQMFLNMTK LEKEAQVEAT SRKEKAKQRP LALNTVEMLR VASSSLGMGP
60 70 80 90 100
QHAMQTAERL YTQGYISYPR TETTHYPENF DLKGSLRQQA NHPYWADTVK
110 120 130 140 150
RLLAEGINRP RKGHDAGDHP PITPMKSATE AELGFAVCPA QRLCKQELAA
160
RARVLGAPHG QSPQLAPN
Length:168
Mass (Da):18,658
Last modified:April 18, 2012 - v1
Checksum:i22488C1D712B94FA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC245452 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000436282; ENSP00000416451; ENSG00000100038.
UCSCiuc062cao.1. human.

Entry informationi

Entry nameiH7C4B0_HUMAN
AccessioniPrimary (citable) accession number: H7C4B0
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: September 27, 2017
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported