ID   H7C495_HUMAN            Unreviewed;       149 AA.
AC   H7C495;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 57.
DE   SubName: Full=Tumor protein p53 binding protein 1 {ECO:0000313|Ensembl:ENSP00000416212.1};
DE   Flags: Fragment;
GN   Name=TP53BP1 {ECO:0000313|Ensembl:ENSP00000416212.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000416212.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000416212.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16572171; DOI=10.1038/nature04601;
RA   Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA   Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA   FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA   Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA   Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA   DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA   Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA   Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA   Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA   O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M., Stewart S.,
RA   Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R.,
RA   Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT   "Analysis of the DNA sequence and duplication history of human chromosome
RT   15.";
RL   Nature 440:671-675(2006).
RN   [2] {ECO:0000313|Ensembl:ENSP00000416212.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AC018924; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   MassIVE; H7C495; -.
DR   MaxQB; H7C495; -.
DR   PeptideAtlas; H7C495; -.
DR   ProteomicsDB; 45597; -.
DR   Antibodypedia; 1749; 1100 antibodies from 41 providers.
DR   Ensembl; ENST00000434595.1; ENSP00000416212.1; ENSG00000067369.14.
DR   UCSC; uc059ijo.1; human.
DR   HGNC; HGNC:11999; TP53BP1.
DR   VEuPathDB; HostDB:ENSG00000067369; -.
DR   GeneTree; ENSGT00390000011891; -.
DR   HOGENOM; CLU_1762964_0_0_1; -.
DR   ChiTaRS; TP53BP1; human.
DR   Proteomes; UP000005640; Chromosome 15.
DR   Bgee; ENSG00000067369; Expressed in pituitary gland and 200 other cell types or tissues.
DR   ExpressionAtlas; H7C495; baseline and differential.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR   CDD; cd17745; BRCT_p53bp1_rpt1; 1.
DR   Gene3D; 3.40.50.10190; BRCT domain; 1.
DR   InterPro; IPR036420; BRCT_dom_sf.
DR   InterPro; IPR047249; BRCT_p53bp1-like_rpt1.
DR   InterPro; IPR047252; TP53BP1-like.
DR   PANTHER; PTHR15321:SF3; TP53-BINDING PROTEIN 1; 1.
DR   PANTHER; PTHR15321; TUMOR SUPPRESSOR P53-BINDING PROTEIN 1; 1.
DR   SUPFAM; SSF52113; BRCT domain; 1.
PE   1: Evidence at protein level;
KW   DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Proteomics identification {ECO:0007829|EPD:H7C495,
KW   ECO:0007829|MaxQB:H7C495};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   REGION          39..66
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000416212.1"
FT   NON_TER         149
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000416212.1"
SQ   SEQUENCE   149 AA;  16478 MW;  B2761EAAB778156E CRC64;
     XTGEPSALEE QRGPLPLNKT LFLGYAFLLT MATTSDKLAS RSKLPDGPTG SSEEEEAYCN
     HPSQSGLNAL PSSPFAFYGH LLEQTHVEEF LEIPPFNKQY TESQLRAGAG YILEDFNEAQ
     CNTAYQCLLI ADQHCRTRKY FLCLASGIP
//