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Protein

Claudin-34

Gene

CLDN34

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.By similarity

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Claudin-34Curated
Gene namesi
Name:CLDN34Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000234469.4.
HGNCiHGNC:51259. CLDN34.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicCuratedAdd BLAST11
Transmembranei12 – 32HelicalSequence analysisAdd BLAST21
Topological domaini33 – 80ExtracellularCuratedAdd BLAST48
Transmembranei81 – 101HelicalSequence analysisAdd BLAST21
Topological domaini102 – 125CytoplasmicCuratedAdd BLAST24
Transmembranei126 – 146HelicalSequence analysisAdd BLAST21
Topological domaini147 – 177ExtracellularCuratedAdd BLAST31
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 214CytoplasmicCuratedAdd BLAST16

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004332201 – 214Claudin-34Add BLAST214

Proteomic databases

PaxDbiH7C241.
PRIDEiH7C241.

Expressioni

Gene expression databases

BgeeiENSG00000234469.

Interactioni

Subunit structurei

Can form homo- and heteropolymers with other CLDN.By similarity

Structurei

3D structure databases

ProteinModelPortaliH7C241.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the claudin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYW7. Eukaryota.
ENOG4111PMW. LUCA.
GeneTreeiENSGT00390000005717.
InParanoidiH7C241.
OMAiGLVEWRI.
OrthoDBiEOG091G0MJS.

Family and domain databases

InterProiView protein in InterPro
IPR006187. Claudin.
PANTHERiPTHR12002. PTHR12002. 1 hit.

Sequencei

Sequence statusi: Complete.

H7C241-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVWFCNSADC QFSVFALTTI GWILSSTSTG LVEWRIWYMK DTSLYPPGIA
60 70 80 90 100
CVGIFRVCIY RRRTNSTTTK FCYRYSYQDT FLPFEISMAQ RFLLTASIFG
110 120 130 140 150
FFGRAFNMFA LRNMSMRMFE EDTYNSFVVS GILNIAAGVF NLIAVLQNYD
160 170 180 190 200
AVINSQGITF LPSLQMPFKP DVQEVGTAIQ VAGIGVLPML LTGMFSLFYK
210
CPPYGQVHPG ISEM
Length:214
Mass (Da):24,226
Last modified:October 29, 2014 - v2
Checksum:i6E9D8052B77F6896
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002365 Genomic DNA. No translation available.
CCDSiCCDS75951.1.
RefSeqiNP_001182010.1. NM_001195081.1.
UniGeneiHs.722001.

Genome annotation databases

EnsembliENST00000445307; ENSP00000403980; ENSG00000234469.
GeneIDi100288814.
KEGGihsa:100288814.
UCSCiuc022bsu.2. human.

Similar proteinsi

Entry informationi

Entry nameiCLD34_HUMAN
AccessioniPrimary (citable) accession number: H7C241
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 24, 2015
Last sequence update: October 29, 2014
Last modified: September 27, 2017
This is version 34 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families