ID   H7C219_HUMAN            Unreviewed;       158 AA.
AC   H7C219;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 52.
DE   SubName: Full=Ring finger protein 25 {ECO:0000313|Ensembl:ENSP00000403582.1};
DE   Flags: Fragment;
GN   Name=RNF25 {ECO:0000313|Ensembl:ENSP00000403582.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000403582.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000403582.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0000313|Ensembl:ENSP00000403582.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC009974; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H7C219; -.
DR   MassIVE; H7C219; -.
DR   MaxQB; H7C219; -.
DR   PeptideAtlas; H7C219; -.
DR   ProteomicsDB; 44836; -.
DR   Ensembl; ENST00000423170.1; ENSP00000403582.1; ENSG00000163481.8.
DR   UCSC; uc061sns.1; human.
DR   HGNC; HGNC:14662; RNF25.
DR   VEuPathDB; HostDB:ENSG00000163481; -.
DR   GeneTree; ENSGT00390000001557; -.
DR   HOGENOM; CLU_1673246_0_0_1; -.
DR   ChiTaRS; RNF25; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000163481; Expressed in adenohypophysis and 149 other cell types or tissues.
DR   ExpressionAtlas; H7C219; baseline and differential.
DR   GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR   Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR   InterPro; IPR039133; RNF25.
DR   InterPro; IPR006575; RWD_dom.
DR   InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR   PANTHER; PTHR13198:SF4; E3 UBIQUITIN-PROTEIN LIGASE RNF25; 1.
DR   PANTHER; PTHR13198; RING FINGER PROTEIN 25; 1.
DR   Pfam; PF05773; RWD; 1.
DR   SUPFAM; SSF54495; UBC-like; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|MaxQB:H7C219,
KW   ECO:0007829|PeptideAtlas:H7C219};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          17..65
FT                   /note="RWD"
FT                   /evidence="ECO:0000259|Pfam:PF05773"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000403582.1"
SQ   SEQUENCE   158 AA;  17613 MW;  125CA93309BC253D CRC64;
     AASASAAAGE EDWVLPSEVE VLESIYLDEL QVIKGNGRTS PWEIYITLHP ATAEDQDSHI
     PMRCHRSLSE IPEDFQMNRS TRSYRCWATW PRLGWALPCC MNSLRKGRKF SQITTSLMAS
     VSSASMVSRR RRPLPKHPVT TTSTATALLG TSSTWSKS
//