ID   H7C1P0_HUMAN            Unreviewed;       111 AA.
AC   H7C1P0;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 60.
DE   SubName: Full=Replication factor C subunit 4 {ECO:0000313|Ensembl:ENSP00000401429.1};
DE   Flags: Fragment;
GN   Name=RFC4 {ECO:0000313|Ensembl:ENSP00000401429.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000401429.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000401429.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16641997; DOI=10.1038/nature04728;
RA   Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J.,
RA   Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P.,
RA   Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A.,
RA   Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L.,
RA   Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G.,
RA   Sodergren E., Song X.Z., Steffen D., Wei S., Wheeler D.A., Wright M.W.,
RA   Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M.,
RA   Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P.,
RA   Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H.,
RA   Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J.,
RA   Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W.,
RA   Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B.,
RA   Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O.,
RA   Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
RA   Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
RA   Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
RA   Wang J., Wang Q., Williams G.A., Wong G.K., Yao Z., Zhang J., Zhang X.,
RA   Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R.,
RA   Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.;
RT   "The DNA sequence, annotation and analysis of human chromosome 3.";
RL   Nature 440:1194-1198(2006).
RN   [2] {ECO:0007829|PubMed:21269460}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA   Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Burckstummer T.,
RA   Bennett K.L., Superti-Furga G., Colinge J.;
RT   "Initial characterization of the human central proteome.";
RL   BMC Syst. Biol. 5:17-17(2011).
RN   [3] {ECO:0000313|Ensembl:ENSP00000401429.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   EMBL; AC112907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H7C1P0; -.
DR   SMR; H7C1P0; -.
DR   MassIVE; H7C1P0; -.
DR   MaxQB; H7C1P0; -.
DR   PeptideAtlas; H7C1P0; -.
DR   ProteomicsDB; 44709; -.
DR   Antibodypedia; 3877; 317 antibodies from 33 providers.
DR   Ensembl; ENST00000417876.1; ENSP00000401429.1; ENSG00000163918.12.
DR   UCSC; uc062rfi.1; human.
DR   HGNC; HGNC:9972; RFC4.
DR   VEuPathDB; HostDB:ENSG00000163918; -.
DR   GeneTree; ENSGT00550000074917; -.
DR   HOGENOM; CLU_042324_4_0_1; -.
DR   ChiTaRS; RFC4; human.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; ENSG00000163918; Expressed in ventricular zone and 190 other cell types or tissues.
DR   ExpressionAtlas; H7C1P0; baseline and differential.
DR   GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR   Gene3D; 1.10.8.60; -; 1.
DR   Gene3D; 1.20.272.10; -; 1.
DR   InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR   InterPro; IPR013748; Rep_factorC_C.
DR   PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR   PANTHER; PTHR11669:SF20; REPLICATION FACTOR C SUBUNIT 4; 1.
DR   Pfam; PF08542; Rep_fac_C; 1.
DR   SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE   1: Evidence at protein level;
KW   Proteomics identification {ECO:0007829|EPD:H7C1P0,
KW   ECO:0007829|MaxQB:H7C1P0};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640}.
FT   DOMAIN          45..109
FT                   /note="Replication factor C C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08542"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000401429.1"
SQ   SEQUENCE   111 AA;  11850 MW;  F1536DA3DB5A5CCA CRC64;
     GIAYLVKVSE GDLRKAITFL QSATRLTGGK EITEKVITDI AGVIPAEKID GVFAACQSGS
     FDKLEAVVKD LIDEGHAATQ LVNQLHDVVV ENNLSDKQKS IITEKLALTN A
//