ID   H7C1G6_HUMAN            Unreviewed;       244 AA.
AC   H7C1G6;
DT   18-APR-2012, integrated into UniProtKB/TrEMBL.
DT   18-APR-2012, sequence version 1.
DT   27-MAR-2024, entry version 74.
DE   RecName: Full=Autophagy-related protein 9 {ECO:0000256|RuleBase:RU364027};
DE   Flags: Fragment;
GN   Name=ATG9A {ECO:0000313|Ensembl:ENSP00000400234.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|Ensembl:ENSP00000400234.1, ECO:0000313|Proteomes:UP000005640};
RN   [1] {ECO:0000313|Ensembl:ENSP00000400234.1, ECO:0000313|Proteomes:UP000005640}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2] {ECO:0007829|PubMed:18669648}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [3] {ECO:0007829|PubMed:20068231}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA   Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA   Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT   "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT   site occupancy during mitosis.";
RL   Sci. Signal. 3:RA3-RA3(2010).
RN   [4] {ECO:0007829|PubMed:23186163}
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=23186163;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
RN   [5] {ECO:0000313|Ensembl:ENSP00000400234.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: Phospholipid scramblase involved in autophagy. Cycles between
CC       the preautophagosomal structure/phagophore assembly site (PAS) and the
CC       cytoplasmic vesicle pool and supplies membrane for the growing
CC       autophagosome. Lipid scramblase activity plays a key role in
CC       preautophagosomal structure/phagophore assembly by distributing the
CC       phospholipids that arrive through ATG2 from the cytoplasmic to the
CC       luminal leaflet of the bilayer, thereby driving autophagosomal membrane
CC       expansion. {ECO:0000256|RuleBase:RU364027}.
CC   -!- SUBCELLULAR LOCATION: Endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004337}. Late endosome membrane
CC       {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004107}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}. Preautophagosomal structure membrane
CC       {ECO:0000256|ARBA:ARBA00004511, ECO:0000256|RuleBase:RU364027}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004511,
CC       ECO:0000256|RuleBase:RU364027}.
CC   -!- SIMILARITY: Belongs to the ATG9 family. {ECO:0000256|ARBA:ARBA00006185,
CC       ECO:0000256|RuleBase:RU364027}.
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DR   EMBL; AC068946; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; H7C1G6; -.
DR   SMR; H7C1G6; -.
DR   MassIVE; H7C1G6; -.
DR   MaxQB; H7C1G6; -.
DR   PeptideAtlas; H7C1G6; -.
DR   ProteomicsDB; 44636; -.
DR   Antibodypedia; 34308; 488 antibodies from 38 providers.
DR   Ensembl; ENST00000429920.1; ENSP00000400234.1; ENSG00000198925.12.
DR   UCSC; uc061ssr.1; human.
DR   HGNC; HGNC:22408; ATG9A.
DR   VEuPathDB; HostDB:ENSG00000198925; -.
DR   GeneTree; ENSGT00390000014839; -.
DR   HOGENOM; CLU_1140225_0_0_1; -.
DR   ChiTaRS; ATG9A; human.
DR   Proteomes; UP000005640; Chromosome 2.
DR   Bgee; ENSG00000198925; Expressed in gastrocnemius and 97 other cell types or tissues.
DR   ExpressionAtlas; H7C1G6; baseline and differential.
DR   GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR   GO; GO:0034045; C:phagophore assembly site membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR   GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR007241; Autophagy-rel_prot_9.
DR   PANTHER; PTHR13038; APG9 AUTOPHAGY 9; 1.
DR   PANTHER; PTHR13038:SF13; AUTOPHAGY-RELATED PROTEIN 9A; 1.
DR   Pfam; PF04109; ATG9; 1.
PE   1: Evidence at protein level;
KW   Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW   Autophagy {ECO:0000256|ARBA:ARBA00023006, ECO:0000256|RuleBase:RU364027};
KW   Endosome {ECO:0000256|ARBA:ARBA00022753};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Lipid transport {ECO:0000256|RuleBase:RU364027};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Proteomics identification {ECO:0007829|EPD:H7C1G6,
KW   ECO:0007829|MaxQB:H7C1G6};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005640};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW   Transport {ECO:0000256|RuleBase:RU364027}.
FT   REGION          212..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        214..244
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000400234.1"
FT   NON_TER         244
FT                   /evidence="ECO:0000313|Ensembl:ENSP00000400234.1"
SQ   SEQUENCE   244 AA;  26759 MW;  71F9B0004318F3AA CRC64;
     LAHIHYMPDH WQGNAHRSQT RDEFAQLFQY KAVFILEELL SPIVTPLILI FCLRPRALEI
     IDFFRNFTVE VVGVGDTCSF AQMDVRQHGH PQWLSAGQTE ASVYQQAEDG KTELSLMHFA
     ITNPGWQPPR ESTAFLGFLK EQVQRDGAAA SLAQGGLLPE NALFTSIQSL QSESEPLSLI
     ANVVAGSSCR GPPLPRDLQG SRHRAEVASA LRSFSPLQPG QAPTGRAHST MTGSGSTSSR
     PRLN
//