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Protein
Submitted name:

Transient receptor potential cation channel subfamily M member 8

Gene

TRPM8

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. ion channel activity Source: InterPro

GO - Biological processi

  1. cation transport Source: InterPro
  2. detection of temperature stimulus Source: InterPro
  3. sensory perception of temperature stimulus Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotation

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Submitted name:
Transient receptor potential cation channel subfamily M member 8Imported
Gene namesi
Name:TRPM8Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:17961. TRPM8.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiH7BZP4.
ExpressionAtlasiH7BZP4. baseline and differential.

Interactioni

Structurei

3D structure databases

ProteinModelPortaliH7BZP4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

TransmembraneUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000119127.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029603. TRPM8.
[Graphical view]
PANTHERiPTHR13800:SF9. PTHR13800:SF9. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

H7BZP4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GRVIFCLDYI IFTLRLIHIF TVSRNLGPKI IMLQRMLIDV FFFLFLFAVW
60 70 80 90 100
MVAFGVARQG ILRQNEQRWR WIFRSVIYEP YLAMFGQVPS DVDGKPDLAQ
110 120 130
METAWRRHLL PEPTPRAAPE TALQKHARET ESNITEYHV
Length:139
Mass (Da):16,424
Last modified:April 18, 2012 - v1
Checksum:iC255D4C257FEA685
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005538 Genomic DNA. No translation available.
KF510796 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000439148; ENSP00000390609; ENSG00000144481.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005538 Genomic DNA. No translation available.
KF510796 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliH7BZP4.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiH7BZP4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000439148; ENSP00000390609; ENSG00000144481.

Organism-specific databases

HGNCiHGNC:17961. TRPM8.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119127.

Miscellaneous databases

NextBioi35528573.

Gene expression databases

BgeeiH7BZP4.
ExpressionAtlasiH7BZP4. baseline and differential.

Family and domain databases

InterProiIPR005821. Ion_trans_dom.
IPR029603. TRPM8.
[Graphical view]
PANTHERiPTHR13800:SF9. PTHR13800:SF9. 1 hit.
PfamiPF00520. Ion_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH7BZP4_HUMAN
AccessioniPrimary (citable) accession number: H7BZP4
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: January 7, 2015
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.