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Protein
Submitted name:

Aromatic-L-amino-acid decarboxylase

Gene

DDC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyaseUniRule annotation
LigandPyridoxal phosphateUniRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Aromatic-L-amino-acid decarboxylaseImported
Gene namesi
Name:DDCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000132437.17.
HGNCiHGNC:2719. DDC.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132437.

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei184N6-(pyridoxal phosphate)lysineUniRule annotation1

Proteomic databases

MaxQBiH7BZF7.
PeptideAtlasiH7BZF7.
PRIDEiH7BZF7.

Expressioni

Gene expression databases

BgeeiENSG00000132437.
ExpressionAtlasiH7BZF7. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH7BZF7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the group II decarboxylase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0628. Eukaryota.
COG0076. LUCA.
GeneTreeiENSGT00760000119205.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiView protein in InterPro
IPR010977. Aromatic_deC.
IPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_sub2.
IPR021115. Pyridoxal-P_BS.
PfamiView protein in Pfam
PF00282. Pyridoxal_deC. 1 hit.
PRINTSiPR00800. YHDCRBOXLASE.
SUPFAMiSSF53383. SSF53383. 1 hit.
PROSITEiView protein in PROSITE
PS00392. DDC_GAD_HDC_YDC. 1 hit.

Sequencei

Sequence statusi: Fragment.

H7BZF7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
XGYLRPLIPA AAPQEPDTFE DIINDVEKII MPGVTHWHSP YFFAYFPTAS
60 70 80 90 100
SYPAMLADML CGAIGCIGFS WAHSSVERAG LIGGVKLKAI PSDGNFAMRA
110 120 130 140 150
SALQEALERD KAAGLIPFFM VATLGTTTCC SFDNLLEVGP ICNKEDIWLH
160 170 180 190 200
VDAAYAGSAF ICPEFRHLLN GVEFADSFNF NPHKWLLVNF DCSAMWVKKR
210 220 230 240 250
TDLTGAFRLD PTYLKHSHQD SGLITDYRHW QIPLGRRFRS LKMWFVFRMY
260 270 280 290 300
GVKGLQAYIR KHVQLSHEFE SLVRQDPRFE ICVEVILGLV CFRLKGSNKV
310 320 330 340 350
NEALLQRINS AKKIHLVPCH LRDKFVLRFA ICSRTVESAH VQRAWEHIKE
360
LAADVLRAER E
Length:361
Mass (Da):40,974
Last modified:April 18, 2012 - v1
Checksum:i2AF487D1830FE0AB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018705 Genomic DNA. No translation available.
KF511039 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000430300; ENSP00000389422; ENSG00000132437.
UCSCiuc064dqg.1. human.

Similar proteinsi

Entry informationi

Entry nameiH7BZF7_HUMAN
AccessioniPrimary (citable) accession number: H7BZF7
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: January 31, 2018
This is version 30 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported