Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Potassium voltage-gated channel subfamily C member 4

Gene

KCNC4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channelSAAS annotation, Voltage-gated channelSAAS annotation
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Submitted name:
Potassium voltage-gated channel subfamily C member 4Imported
Gene namesi
Name:KCNC4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000116396.13
HGNCiHGNC:6236 KCNC4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei381 – 402HelicalSequence analysisAdd BLAST22
Transmembranei423 – 440HelicalSequence analysisAdd BLAST18
Transmembranei452 – 481HelicalSequence analysisAdd BLAST30

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000116396

PTM / Processingi

Proteomic databases

PRIDEiH7BZ66

Expressioni

Gene expression databases

BgeeiENSG00000116396
ExpressionAtlasiH7BZ66 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH7BZ66
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 151BTBInterPro annotationAdd BLAST116

Sequence similaritiesi

Belongs to the potassium channel family.SAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3713 Eukaryota
COG1226 LUCA
GeneTreeiENSGT00760000118846

Family and domain databases

Gene3Di1.20.120.350, 1 hit
InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR005821 Ion_trans_dom
IPR003968 K_chnl_volt-dep_Kv
IPR003974 K_chnl_volt-dep_Kv3
IPR005405 K_chnl_volt-dep_Kv3.4
IPR021105 K_chnl_volt-dep_Kv3_ID
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
IPR028325 VG_K_chnl
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR11537 PTHR11537, 1 hit
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
PF00520 Ion_trans, 1 hit
PF11404 Potassium_chann, 1 hit
PRINTSiPR00169 KCHANNEL
PR01583 KV34CHANNEL
PR01491 KVCHANNEL
PR01498 SHAWCHANNEL
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequencei

Sequence statusi: Complete.

H7BZ66-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MISSVCVSSY RGRKSGNKPP SKTCLKEEMA KGEASEKIII NVGGTRHETY
60 70 80 90 100
RSTLRTLPGT RLAWLADPDG GGRPETDGGG VGSSGSSGGG GCEFFFDRHP
110 120 130 140 150
GVFAYVLNYY RTGKLHCPAD VCGPLFEEEL TFWGIDETDV EPCCWMTYRQ
160 170 180 190 200
HRDAEEALDI FESPDGGGSG AGPSDEAGDD ERELALQRLG PHEGGAGHGA
210 220 230 240 250
GSGGCRGWQP RMWALFEDPY SSRAARVVAF ASLFFILVSI TTFCLETHEA
260 270 280 290 300
FNIDRNVTEI LRVGNITSVH FRREVETEPI LTYIEGVCVL WFTLEFLVRI
310 320 330 340 350
VCCPDTLDFV KNLLNIIDFV AILPFYLEVG LSGLSSKAAR DVLGFLRVVR
360 370 380 390 400
FVRILRIFKL TRHFVGLRVL GHTLRASTNE FLLLIIFLAL GVLIFATMIY
410 420 430 440 450
YAERIGARPS DPRGNDHTDF KNIPIGFWWA VVTMTTLGYG DMYPKTWSGM
460 470 480 490 500
LVGALCALAG VLTIAMPVPV IVNNFGMYYS LAMAKQKLPK KRKKHVPRPA
510 520 530 540 550
QLESPMYCKS EETSPRDSTC SDTSPPAREE GMIERKRADS KQNGDANAVL
560 570 580 590 600
SDEEGAGLTQ PLASSPTPEE RRALRRSTTR DRNKKAAACF LLSTGDYACA
610 620
DGSVRKEGNV EPKACVPVSH TCAL
Length:624
Mass (Da):68,534
Last modified:April 18, 2012 - v1
Checksum:i4DDB02B109755197
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137790 Genomic DNA No translation available.
RefSeqiXP_006710690.1, XM_006710627.3
UniGeneiHs.153521

Genome annotation databases

EnsembliENST00000413138; ENSP00000388029; ENSG00000116396
GeneIDi3749
UCSCiuc057jdj.1 human

Similar proteinsi

Entry informationi

Entry nameiH7BZ66_HUMAN
AccessioniPrimary (citable) accession number: H7BZ66
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health