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Protein

Cysteine protease

Gene

ATG4A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol proteaseSAAS annotation
Biological processAutophagyUniRule annotationSAAS annotation, Protein transportUniRule annotationSAAS annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine proteaseUniRule annotation (EC:3.4.22.-UniRule annotation)
Gene namesi
Name:ATG4AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:16489. ATG4A.

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000101844.

PTM / Processingi

Proteomic databases

MaxQBiH7BYM2.
PRIDEiH7BYM2.

Expressioni

Gene expression databases

ExpressionAtlasiH7BYM2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliH7BYM2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C54 family.UniRule annotationSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00530000063000.

Family and domain databases

InterProiView protein in InterPro
IPR033474. ATG4A.
IPR005078. Peptidase_C54.
PANTHERiPTHR22624. PTHR22624. 1 hit.
PTHR22624:SF41. PTHR22624:SF41. 1 hit.
PfamiView protein in Pfam
PF03416. Peptidase_C54. 1 hit.

Sequencei

Sequence statusi: Fragment.

H7BYM2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
XLSKYEDQIT IFTDYLEEYP DTDELVWILG KQHLLKTGGT GPSSDAGWGC
60 70 80 90 100
MLRCGQMMLA QALICRHLGR DWSWEKQKEQ PKEYQRILQC FLDRKDCCYS
110 120 130 140 150
IHQMAQMGVG EGKSIGEWFG PNTVAQVLKK LALFDEWNSL AVYVSMDNTV
160 170 180 190 200
VIEDIKKMCR VLPLSADTAG DRPPDSLTAS NQSKGTSAYC SAWKPLLLIV
210 220 230 240 250
PLRLGINQIN PVYVDAFKEC FKMPQSLGAL GGKPNNAYYF IGFLGDELIF
260 270 280 290 300
LDPHTTQTFV DTEENGTVND QTFHCLQSPQ RMNILNLDPS VALGFFCKEE
310
KDFDNWCSLV QK
Length:312
Mass (Da):35,252
Last modified:April 18, 2012 - v1
Checksum:i9193B66B429C7E60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei312Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031177 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000394892; ENSP00000378354; ENSG00000101844.
UCSCiuc065aqc.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL031177 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliH7BYM2.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiH7BYM2.
PRIDEiH7BYM2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394892; ENSP00000378354; ENSG00000101844.
UCSCiuc065aqc.1. human.

Organism-specific databases

HGNCiHGNC:16489. ATG4A.
OpenTargetsiENSG00000101844.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00530000063000.

Gene expression databases

ExpressionAtlasiH7BYM2. baseline and differential.

Family and domain databases

InterProiView protein in InterPro
IPR033474. ATG4A.
IPR005078. Peptidase_C54.
PANTHERiPTHR22624. PTHR22624. 1 hit.
PTHR22624:SF41. PTHR22624:SF41. 1 hit.
PfamiView protein in Pfam
PF03416. Peptidase_C54. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiH7BYM2_HUMAN
AccessioniPrimary (citable) accession number: H7BYM2
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: March 15, 2017
This is version 28 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.