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Protein
Submitted name:

Citron Rho-interacting kinase

Gene

CIT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Citron Rho-interacting kinaseImported
Gene namesi
Name:CITImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000122966.13
HGNCiHGNC:1985 CIT

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000122966

PTM / Processingi

Proteomic databases

EPDiH7BYJ3
MaxQBiH7BYJ3
PeptideAtlasiH7BYJ3
PRIDEiH7BYJ3

Expressioni

Gene expression databases

BgeeiENSG00000122966
ExpressionAtlasiH7BYJ3 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliH7BYJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 59AGC-kinase C-terminalInterPro annotationAdd BLAST59
Domaini975 – 1024Phorbol-ester/DAG-typeInterPro annotationAdd BLAST50
Domaini1056 – 1176PHInterPro annotationAdd BLAST121
Domaini1204 – 1494CNHInterPro annotationAdd BLAST291

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili86 – 216Sequence analysisAdd BLAST131
Coiled coili224 – 244Sequence analysisAdd BLAST21
Coiled coili252 – 341Sequence analysisAdd BLAST90
Coiled coili353 – 422Sequence analysisAdd BLAST70
Coiled coili444 – 471Sequence analysisAdd BLAST28
Coiled coili479 – 670Sequence analysisAdd BLAST192
Coiled coili682 – 709Sequence analysisAdd BLAST28
Coiled coili721 – 797Sequence analysisAdd BLAST77
Coiled coili805 – 825Sequence analysisAdd BLAST21
Coiled coili871 – 905Sequence analysisAdd BLAST35

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0612 Eukaryota
KOG0976 Eukaryota
ENOG410XR1Q LUCA
GeneTreeiENSGT00760000118994

Family and domain databases

CDDicd00029 C1, 1 hit
Gene3Di2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR000961 AGC-kinase_C
IPR017405 Citron_Rho-interacting_kinase
IPR001180 CNH_dom
IPR002219 PE/DAG-bd
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR22988:SF26 PTHR22988:SF26, 3 hits
PfamiView protein in Pfam
PF00780 CNH, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00109 C1, 1 hit
SM00036 CNH, 1 hit
SM00233 PH, 1 hit
SM00133 S_TK_X, 1 hit
PROSITEiView protein in PROSITE
PS51285 AGC_KINASE_CTER, 1 hit
PS50219 CNH, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS00479 ZF_DAG_PE_1, 1 hit
PS50081 ZF_DAG_PE_2, 1 hit

Sequencei

Sequence statusi: Fragment.

H7BYJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
XPFVPTLKSD DDTSNFDEPE KNSWVSSSPC QLSPSGFSGE ELPFVGFSYS
60 70 80 90 100
KALGILGRSE SVVSGLDSPA KTSSMEKKLL IKSKELQDSQ DKCHKMEQEM
110 120 130 140 150
TRLHRRVSEV EAVLSQKEVE LKASETQRSL LEQDLATYIT ECSSLKRSLE
160 170 180 190 200
QARMEVSQED DKALQLLHDI REQSRKLQEI KEQEYQAQVE EMRLMMNQLE
210 220 230 240 250
EDLVSARRRS DLYESELRES RLAAEEFKRK ATECQHKLLK AKDQGKPEVG
260 270 280 290 300
EYAKLEKINA EQQLKIQELQ EKLEKAVKAS TEATELLQNI RQAKERAERE
310 320 330 340 350
LEKLQNREDS SEGIRKKLVE AEELEEKHRE AQVSAQHLEV HLKQKEQHYE
360 370 380 390 400
EKIKVLDNQI KKDLADKETL ENMMQRHEEE AHEKGKILSE QKAMINAMDS
410 420 430 440 450
KIRSLEQRIV ELSEANKLAA NSSLFTQRNM KAQEEMISEL RQQKFYLETQ
460 470 480 490 500
AGKLEAQNRK LEEQLEKISH QDHSDKNRLL ELETRLREVS LEHEEQKLEL
510 520 530 540 550
KRQLTELQLS LQERESQLTA LQAARAALES QLRQAKTELE ETTAEAEEEI
560 570 580 590 600
QALTAHRDEI QRKFDALRNS CTVITDLEEQ LNQLTEDNAE LNNQNFYLSK
610 620 630 640 650
QLDEASGAND EIVQLRSEVD HLRREITERE MQLTSQKQTM EALKTTCTML
660 670 680 690 700
EEQVMDLEAL NDELLEKERQ WEAWRSVLGD EKSQFECRVR ELQRMLDTEK
710 720 730 740 750
QSRARADQRI TESRQVVELA VKEHKAEILA LQQALKEQKL KAESLSDKLN
760 770 780 790 800
DLEKKHAMLE MNARSLQQKL ETERELKQRL LEEQAKLQQQ MDLQKNHIFR
810 820 830 840 850
LTQGLQEALD RADLLKTERS DLEYQLENIQ VLYSHEKVKM EGTISQQTKL
860 870 880 890 900
IDFLQAKMDQ PAKKKKVPLQ YNELKLALEK EKARCAELEE ALQKTRIELR
910 920 930 940 950
SAREEAAHRK ATDHPHPSTP ATARQQIAMS AIVRSPEHQP SAMSLLAPPS
960 970 980 990 1000
SRRKESSTPE EFSRRLKERM HHNIPHRFNV GLNMRATKCA VCLDTVHFGR
1010 1020 1030 1040 1050
QASKCLECQV MCHPKCSTCL PATCGLPAEY ATHFTEAFCR DKMNSPGLQT
1060 1070 1080 1090 1100
KEPSSSLHLE GWMKVPRNNK RGQQGWDRKY IVLEGSKVLI YDNEAREAGQ
1110 1120 1130 1140 1150
RPVEEFELCL PDGDVSIHGA VGASELANTA KADVPYILKM ESHPHTTCWP
1160 1170 1180 1190 1200
GRTLYLLAPS FPDKQRWVTA LESVVAGGRV SREKAEADAK LLGNSLLKLE
1210 1220 1230 1240 1250
GDDRLDMNCT LPFSDQVVLV GTEEGLYALN VLKNSLTHVP GIGAVFQIYI
1260 1270 1280 1290 1300
IKDLEKLLMI AGEERALCLV DVKKVKQSLA QSHLPAQPDI SPNIFEAVKG
1310 1320 1330 1340 1350
CHLFGAGKIE NGLCICAAMP SKVVILRYNE NLSKYCIRKE IETSEPCSCI
1360 1370 1380 1390 1400
HFTNYSILIG TNKFYEIDMK QYTLEEFLDK NDHSLAPAVF AASSNSFPVS
1410 1420 1430 1440 1450
IVQVNSAGQR EEYLLCFHEF GVFVDSYGRR SRTDDLKWSR LPLAFAYREP
1460 1470 1480 1490 1500
YLFVTHFNSL EVIEIQARSS AGTPARAYLD IPNPRYLGPA ISSGAIYLAS
1510 1520 1530 1540 1550
SYQDKLRVIC CKGNLVKESG TEHHRGPSTS RSSPNKRGPP TYNEHITKRV
1560 1570 1580 1590 1600
ASSPAPPEGP SHPREPSTPH RYREGRTELR RDKSPGRPLE REKSPGRMLS
1610 1620 1630 1640
TRRERSPGRL FEDSSRGRLP AGAVRTPLSQ VNKVWDQSSV
Length:1,640
Mass (Da):187,416
Last modified:April 18, 2012 - v1
Checksum:i4AA81E1FFEBFA2C0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002563 Genomic DNA No translation available.
AC004813 Genomic DNA No translation available.
AC079317 Genomic DNA No translation available.
KF511174 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000392520; ENSP00000376305; ENSG00000122966
UCSCiuc058txt.1 human

Similar proteinsi

Entry informationi

Entry nameiH7BYJ3_HUMAN
AccessioniPrimary (citable) accession number: H7BYJ3
Entry historyiIntegrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: April 25, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

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