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Protein
Submitted name:

Citron Rho-interacting kinase

Gene

CIT

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Citron Rho-interacting kinaseImported
Gene namesi
Name:CITImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:1985. CIT.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Proteomic databases

EPDiH7BYJ3.
MaxQBiH7BYJ3.
PaxDbiH7BYJ3.

Expressioni

Gene expression databases

ExpressionAtlasiH7BYJ3. baseline and differential.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000376306.

Structurei

3D structure databases

ProteinModelPortaliH7BYJ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 5959AGC-kinase C-terminalInterPro annotationAdd
BLAST
Domaini975 – 102450Phorbol-ester/DAG-typeInterPro annotationAdd
BLAST
Domaini1056 – 1176121PHInterPro annotationAdd
BLAST
Domaini1204 – 1494291CNHInterPro annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili86 – 216131Sequence analysisAdd
BLAST
Coiled coili252 – 34190Sequence analysisAdd
BLAST
Coiled coili353 – 42270Sequence analysisAdd
BLAST
Coiled coili444 – 47128Sequence analysisAdd
BLAST
Coiled coili479 – 670192Sequence analysisAdd
BLAST
Coiled coili682 – 70928Sequence analysisAdd
BLAST
Coiled coili721 – 79777Sequence analysisAdd
BLAST
Coiled coili871 – 90535Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 PH domain.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiKOG0612. Eukaryota.
KOG0976. Eukaryota.
ENOG410XR1Q. LUCA.
GeneTreeiENSGT00760000118994.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR017405. Citron_Rho-interacting_kinase.
IPR001180. CNH_dom.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR22988:SF26. PTHR22988:SF26. 5 hits.
PfamiPF00780. CNH. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

H7BYJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
XPFVPTLKSD DDTSNFDEPE KNSWVSSSPC QLSPSGFSGE ELPFVGFSYS
60 70 80 90 100
KALGILGRSE SVVSGLDSPA KTSSMEKKLL IKSKELQDSQ DKCHKMEQEM
110 120 130 140 150
TRLHRRVSEV EAVLSQKEVE LKASETQRSL LEQDLATYIT ECSSLKRSLE
160 170 180 190 200
QARMEVSQED DKALQLLHDI REQSRKLQEI KEQEYQAQVE EMRLMMNQLE
210 220 230 240 250
EDLVSARRRS DLYESELRES RLAAEEFKRK ATECQHKLLK AKDQGKPEVG
260 270 280 290 300
EYAKLEKINA EQQLKIQELQ EKLEKAVKAS TEATELLQNI RQAKERAERE
310 320 330 340 350
LEKLQNREDS SEGIRKKLVE AEELEEKHRE AQVSAQHLEV HLKQKEQHYE
360 370 380 390 400
EKIKVLDNQI KKDLADKETL ENMMQRHEEE AHEKGKILSE QKAMINAMDS
410 420 430 440 450
KIRSLEQRIV ELSEANKLAA NSSLFTQRNM KAQEEMISEL RQQKFYLETQ
460 470 480 490 500
AGKLEAQNRK LEEQLEKISH QDHSDKNRLL ELETRLREVS LEHEEQKLEL
510 520 530 540 550
KRQLTELQLS LQERESQLTA LQAARAALES QLRQAKTELE ETTAEAEEEI
560 570 580 590 600
QALTAHRDEI QRKFDALRNS CTVITDLEEQ LNQLTEDNAE LNNQNFYLSK
610 620 630 640 650
QLDEASGAND EIVQLRSEVD HLRREITERE MQLTSQKQTM EALKTTCTML
660 670 680 690 700
EEQVMDLEAL NDELLEKERQ WEAWRSVLGD EKSQFECRVR ELQRMLDTEK
710 720 730 740 750
QSRARADQRI TESRQVVELA VKEHKAEILA LQQALKEQKL KAESLSDKLN
760 770 780 790 800
DLEKKHAMLE MNARSLQQKL ETERELKQRL LEEQAKLQQQ MDLQKNHIFR
810 820 830 840 850
LTQGLQEALD RADLLKTERS DLEYQLENIQ VLYSHEKVKM EGTISQQTKL
860 870 880 890 900
IDFLQAKMDQ PAKKKKVPLQ YNELKLALEK EKARCAELEE ALQKTRIELR
910 920 930 940 950
SAREEAAHRK ATDHPHPSTP ATARQQIAMS AIVRSPEHQP SAMSLLAPPS
960 970 980 990 1000
SRRKESSTPE EFSRRLKERM HHNIPHRFNV GLNMRATKCA VCLDTVHFGR
1010 1020 1030 1040 1050
QASKCLECQV MCHPKCSTCL PATCGLPAEY ATHFTEAFCR DKMNSPGLQT
1060 1070 1080 1090 1100
KEPSSSLHLE GWMKVPRNNK RGQQGWDRKY IVLEGSKVLI YDNEAREAGQ
1110 1120 1130 1140 1150
RPVEEFELCL PDGDVSIHGA VGASELANTA KADVPYILKM ESHPHTTCWP
1160 1170 1180 1190 1200
GRTLYLLAPS FPDKQRWVTA LESVVAGGRV SREKAEADAK LLGNSLLKLE
1210 1220 1230 1240 1250
GDDRLDMNCT LPFSDQVVLV GTEEGLYALN VLKNSLTHVP GIGAVFQIYI
1260 1270 1280 1290 1300
IKDLEKLLMI AGEERALCLV DVKKVKQSLA QSHLPAQPDI SPNIFEAVKG
1310 1320 1330 1340 1350
CHLFGAGKIE NGLCICAAMP SKVVILRYNE NLSKYCIRKE IETSEPCSCI
1360 1370 1380 1390 1400
HFTNYSILIG TNKFYEIDMK QYTLEEFLDK NDHSLAPAVF AASSNSFPVS
1410 1420 1430 1440 1450
IVQVNSAGQR EEYLLCFHEF GVFVDSYGRR SRTDDLKWSR LPLAFAYREP
1460 1470 1480 1490 1500
YLFVTHFNSL EVIEIQARSS AGTPARAYLD IPNPRYLGPA ISSGAIYLAS
1510 1520 1530 1540 1550
SYQDKLRVIC CKGNLVKESG TEHHRGPSTS RSSPNKRGPP TYNEHITKRV
1560 1570 1580 1590 1600
ASSPAPPEGP SHPREPSTPH RYREGRTELR RDKSPGRPLE REKSPGRMLS
1610 1620 1630 1640
TRRERSPGRL FEDSSRGRLP AGAVRTPLSQ VNKVWDQSSV
Length:1,640
Mass (Da):187,416
Last modified:April 18, 2012 - v1
Checksum:i4AA81E1FFEBFA2C0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002563 Genomic DNA. No translation available.
AC004813 Genomic DNA. No translation available.
AC079317 Genomic DNA. No translation available.
KF511174 Genomic DNA. No translation available.

Genome annotation databases

EnsembliENST00000392520; ENSP00000376305; ENSG00000122966.
UCSCiuc058txt.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002563 Genomic DNA. No translation available.
AC004813 Genomic DNA. No translation available.
AC079317 Genomic DNA. No translation available.
KF511174 Genomic DNA. No translation available.

3D structure databases

ProteinModelPortaliH7BYJ3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000376306.

Proteomic databases

EPDiH7BYJ3.
MaxQBiH7BYJ3.
PaxDbiH7BYJ3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000392520; ENSP00000376305; ENSG00000122966.
UCSCiuc058txt.1. human.

Organism-specific databases

HGNCiHGNC:1985. CIT.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0612. Eukaryota.
KOG0976. Eukaryota.
ENOG410XR1Q. LUCA.
GeneTreeiENSGT00760000118994.

Miscellaneous databases

ChiTaRSiCIT. human.
NextBioi35528243.

Gene expression databases

ExpressionAtlasiH7BYJ3. baseline and differential.

Family and domain databases

Gene3Di2.30.29.30. 1 hit.
InterProiIPR000961. AGC-kinase_C.
IPR017405. Citron_Rho-interacting_kinase.
IPR001180. CNH_dom.
IPR002219. PE/DAG-bd.
IPR011993. PH_dom-like.
IPR001849. PH_domain.
[Graphical view]
PANTHERiPTHR22988:SF26. PTHR22988:SF26. 5 hits.
PfamiPF00780. CNH. 1 hit.
PF00169. PH. 1 hit.
[Graphical view]
SMARTiSM00109. C1. 1 hit.
SM00036. CNH. 1 hit.
SM00233. PH. 1 hit.
SM00133. S_TK_X. 1 hit.
[Graphical view]
SUPFAMiSSF50729. SSF50729. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS50219. CNH. 1 hit.
PS50003. PH_DOMAIN. 1 hit.
PS00479. ZF_DAG_PE_1. 1 hit.
PS50081. ZF_DAG_PE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The finished DNA sequence of human chromosome 12."
    Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A., null.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  3. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  4. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiH7BYJ3_HUMAN
AccessioniPrimary (citable) accession number: H7BYJ3
Entry historyi
Integrated into UniProtKB/TrEMBL: April 18, 2012
Last sequence update: April 18, 2012
Last modified: May 11, 2016
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.Imported

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.